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  1. #1
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    Default Chromosome testing

    Hi everyone

    I'm hoping that someone can either give me some advice and if not atleast I'll have vented abit!!

    Today we had our appointment with my specialist after having my second miscarriage before xmas. He's so nice but I've left and come home and am more confused on what our next step should be.

    Bit of a back ground story but we have already had two IVF cycles, we have a beautiful little girl which was our first embryo on the second cycle, then we miscarried the second embryo at 11.5 weeks (baby stopped growing at 9 weeks but we didn't realise). The embryo wasn't tested as we weren't given that option at the hospital. Now we have one embryo left and I'm not sure whether to use this embryo or do another IVF cycle and get chromosome testing. Our specialist said that its completely up to us but if we have the money then the testing could be good. Its a lot of money but I mean if it means our chances are better, then maybe this is the way to go but we also have this one embryo left that I don't know if we should just give it a go and hope for the best. I'm also 36 so all this waiting around is doing my head in so I don't know if I'm pushing to go ahead with this embryo because I just want to get moving on this again as soon as I can!

    I'm not sure exactly what my question is cause i know that nobody can tell me what to do and what the future holds but does anyone know how they pick which embryos and with this being my third embryo, does this mean that its not as good as the first two?

    Sorry for this essay, it probably doesn't even make sense but I'm so confused on what to do. I will be ringing the nurses in the next few days with some questions, just wanted to hear from other people aswell.
    Last edited by Margi8; 29-01-2020 at 23:47.

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    Clinics only freeze good quality embryos so I wouldn’t be worried about quality and just because it is not graded as high as the other two (or the could’ve all been the same grade) doesn’t mean it will not result in a healthy pregnancy. One miscarriage does not mean that this embryo will not be fine. It could actually have nothing to do with the embryos at all. I would go ahead and transfer your remaining embryo then if it doesn’t work out you can do another cycle and PGS test then. I would also think about being tested for immune issues like NKC that sometimes show themselves in second pregnancies.
    You can ask the clinic what the grade of the embryo is if you like, they have to tell you.
    Also think about if you want more than one more child. If you do you would need to do another cycle anyway so sooner is better.
    I hope this helps, goodluck with your decision making.

    P.s I had 8 miscarriages before I discovered I had immune issues. They always seem to blame the eggs, not always the issue at all. I am older than you though.

  3. #3
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    Quote Originally Posted by Margi8 View Post
    Hi everyone

    I'm hoping that someone can either give me some advice and if not atleast I'll have vented abit!!

    Today we had our appointment with my specialist after having my second miscarriage before xmas. He's so nice but I've left and come home and am more confused on what our next step should be.

    Bit of a back ground story but we have already had two IVF cycles, we have a beautiful little girl which was our first embryo on the second cycle, then we miscarried the second embryo at 11.5 weeks (baby stopped growing at 9 weeks but we didn't realise). The embryo wasn't tested as we weren't given that option at the hospital. Now we have one embryo left and I'm not sure whether to use this embryo or do another IVF cycle and get chromosome testing. Our specialist said that its completely up to us but if we have the money then the testing could be good. Its a lot of money but I mean if it means our chances are better, then maybe this is the way to go but we also have this one embryo left that I don't know if we should just give it a go and hope for the best. I'm also 36 so all this waiting around is doing my head in so I don't know if I'm pushing to go ahead with this embryo because I just want to get moving on this again as soon as I can!

    I'm not sure exactly what my question is cause i know that nobody can tell me what to do and what the future holds but does anyone know how they pick which embryos and with this being my third embryo, does this mean that its not as good as the first two?

    Sorry for this essay, it probably doesn't even make sense but I'm so confused on what to do. I will be ringing the nurses in the next few days with some questions, just wanted to hear from other people aswell.


    PGD testing doesn't guarantee a pregnancy to term. Many transfer PGD normal blast and they don't take. My PGD normal blast didn't take. It's controversial I feel & so expensive! I know some women have sworn by it but others have not. Personally I wouldn't again but that's because it didn't help me get pregnant.

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    I'm not sure where you're based, but if you miscarried at a state hospital in qld then they have to run tests as standard, they just don't send them to you as an individual but to your doctor.
    I found this out after my first miscarriage in Brisbane, the hospital sent the results to my FS and doctor, but they took about 8 weeks to arrive.

    After 2 confirmed genetic related miscarriages and a third undiagnosed, we did PGS. I would second others comments above that it adds a LOT of cost with little additional guarantee. I had normal embies that didn't take sadly, but it does give some peace of mind that you're giving yourself the best chance.

    It's standard if you're going down the PGS route to have completed basic genetic screening beforehand and then gone for genetic counselling - has this been discussed as being relevant for your situation by your FS?
    If you've not had multiple MC or identified as increased genetic risk, then would be surprised that you'd "need" it. If you want to do it specifically for the mental health aspect, then it comes down to what you can afford it, since it stretches out your cycles to fresh + FET + testing + freezing fees, plus all other allied costs.

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    Quote Originally Posted by Moc24 View Post
    Clinics only freeze good quality embryos so I wouldn’t be worried about quality and just because it is not graded as high as the other two (or the could’ve all been the same grade) doesn’t mean it will not result in a healthy pregnancy. One miscarriage does not mean that this embryo will not be fine. It could actually have nothing to do with the embryos at all. I would go ahead and transfer your remaining embryo then if it doesn’t work out you can do another cycle and PGS test then. I would also think about being tested for immune issues like NKC that sometimes show themselves in second pregnancies.
    You can ask the clinic what the grade of the embryo is if you like, they have to tell you.
    Also think about if you want more than one more child. If you do you would need to do another cycle anyway so sooner is better.
    I hope this helps, goodluck with your decision making.

    P.s I had 8 miscarriages before I discovered I had immune issues. They always seem to blame the eggs, not always the issue at all. I am older than you though.
    Hi Moc24, thanks so much for your reply. I'm going to ask them about the grade of the embryo even though I know that it must be ok or they wouldn't freeze it but it might put my mind at ease.
    This is our second miscarriage but the first one was at 5 weeks, I feel like we might not have even realized if I wasnt going through IVF. We've also had multiple embryos that just didn't take.
    I would have always said that I wanted 3 or 4 kids but I think if we get 2 we'll be very lucky, I feel very lucky to have one already. It just takes so much to even get pregnant that I'm not sure how much longer we'll try for so we might just try this embryo and see what happens.
    Im so sorry that you had 8 miscarriages before you found out the reason, its such a hard thing to go through.

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    Quote Originally Posted by WintersDay View Post
    PGD testing doesn't guarantee a pregnancy to term. Many transfer PGD normal blast and they don't take. My PGD normal blast didn't take. It's controversial I feel & so expensive! I know some women have sworn by it but others have not. Personally I wouldn't again but that's because it didn't help me get pregnant.
    I'm so sorry Wintersday that it didn't work. I think that's one of the frustrating things is that it's so expensive and you put so much faith into the professionals but there's still no guarantee.

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    Quote Originally Posted by Robyn0312 View Post
    I'm not sure where you're based, but if you miscarried at a state hospital in qld then they have to run tests as standard, they just don't send them to you as an individual but to your doctor.
    I found this out after my first miscarriage in Brisbane, the hospital sent the results to my FS and doctor, but they took about 8 weeks to arrive.

    After 2 confirmed genetic related miscarriages and a third undiagnosed, we did PGS. I would second others comments above that it adds a LOT of cost with little additional guarantee. I had normal embies that didn't take sadly, but it does give some peace of mind that you're giving yourself the best chance.

    It's standard if you're going down the PGS route to have completed basic genetic screening beforehand and then gone for genetic counselling - has this been discussed as being relevant for your situation by your FS?
    If you've not had multiple MC or identified as increased genetic risk, then would be surprised that you'd "need" it. If you want to do it specifically for the mental health aspect, then it comes down to what you can afford it, since it stretches out your cycles to fresh + FET + testing + freezing fees, plus all other allied costs.
    Thanks Robyn0312, we're in WA and they told us that they don't usually test, of course when we met our FS he made it seem that we could have got it done if we had pushed which of course makes us feel like crap that we didn't.
    This is my second miscarriage, my first one was very early on at 5weeks but we've also had a few embryos that just didnt work.

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    Quote Originally Posted by Margi8 View Post
    Hi Moc24, thanks so much for your reply. I'm going to ask them about the grade of the embryo even though I know that it must be ok or they wouldn't freeze it but it might put my mind at ease.
    This is our second miscarriage but the first one was at 5 weeks, I feel like we might not have even realized if I wasnt going through IVF. We've also had multiple embryos that just didn't take.
    I would have always said that I wanted 3 or 4 kids but I think if we get 2 we'll be very lucky, I feel very lucky to have one already. It just takes so much to even get pregnant that I'm not sure how much longer we'll try for so we might just try this embryo and see what happens.
    Im so sorry that you had 8 miscarriages before you found out the reason, its such a hard thing to go through.
    Which clinic are you with? I’m also in WA.
    It is common to have embryos that don’t take unfortunately it’s just the way it is.
    Have you thought about get immune testing done? Also have you had a hysteroscopy to make sure everything is good in your uterus?
    I would recommend both it only cost a couple of hundred dollars to get proper testing done and if it all comes back clean then at least you know you’ve ticked that box. Unfortunately the only dr in WA who was doing it has now stoped practicing so you would have to have a phone consultation with Dr Matthius in Sydney.
    I Pgs tested my embryos my last round. 4 out of 8 healthy 5 day blasts came back abnormal. Imagine if I had have transfered those abnormal 4! Would have either resulted in yet another miscarriage or failed to implant and cost me a a fair chunk of coin in transfer fees as well. If you want to some clinics allow you to do two cycles then send all for testing so you only pay for testing once. I know Concept do this in Subiaco.
    Also you can get early release from your super to pay for the ivf cycles and testing incase you didn’t already know that.
    This whole ivf journey really is a rocky road!
    Goodluck with your decisions.

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    Grading is relevant but it’s not a determinant of success. I had top grade embryos tested with PGS that were chromosomally abnormal and my one chromosomally normal embryo that was not that great a grade is now 3 years old. Embryos can look great under the microscope but the chromosomes can be scrambled. It’s just not an exact science yet. Whether you do PGS screening really depends on your circumstances - age, genetic family issues etc. I am in favour of it but I was 43 when I did IVF and so most of my eggs would have been abnormal and so PGS was a no brainer for me.

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  12. #10
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    Quote Originally Posted by Margi8 View Post
    I'm so sorry Wintersday that it didn't work. I think that's one of the frustrating things is that it's so expensive and you put so much faith into the professionals but there's still no guarantee.


    I always wonder if I never PGD tested if it would stick. It was a perfect blast. Mosaic didn't take either. I only tested 1 cycle and would not ever again..I know many others who's PGD didn't take and untested did.


 

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