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  1. #1
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    Default 4 failed embryo transfers in a row. What should i look into?

    Hello ladies,

    I need your advice.

    I'm 34 PCOS, husband 39 low count

    First ICSI all embryos failed

    Second ICSI we got 4 embryos in 2016
    1st FET resulted in pregnancy, then miscarriage at 13 weeks
    2nd FET resulted in pregnancy - my daughter 2 years old

    2019
    3rd FET BFN (got to blood test)
    4th FET BFN (ended after 6 days)

    Third ICSI we got 3 embryos
    5th FET BFN (ended after 6 days)
    6th FET BFN (ended after 7 days)

    SO if youre still reading we have had 4 embryos transferred this year. My doctor seems to think the results are normal and hasn't recommended we do anything new or look into anything else. We haven't done any new tests since 2016 and we use embryo glue every time.

    Should I see a new doctor before we transfer our last embryo? This most likely is our last chance. Should I have any certain blood tests? Should I have a lap? I don't know where to go from here. Any suggestions or advice would be appreciated

  2. #2
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    Hi,

    I remember being told that from each cycle they only expect one to work (if that) anything else is a bonus and you had 2 from that cycle work (sorry I know you miscarried but it did implant) and you also have a daughter too so that’s a great result from that cycle, I wouldn’t be too worried that the others didn’t take considering some did from that cycle. You know your body better better than anyone so if you strongly feel that something is wrong then definitely push for more tests but you I’d give another stim cycle a go first. Good luck!

  3. #3
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    Sorry, but I don't know much about drug protocol with PCOS. Perhaps if you commented on that too it could help. Timing is so important which includes your lining thickness.

  4. #4
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    Thank you very much for replying

  5. #5
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    Thanks for your replies. I am truly lucky I got pregnant twice from 4 embryos. I think that's why I'm so shocked and confused that nothing has come from 2 new embryos from new batch. Everyday I'm grateful for my daughter. At $3000 a transfer its just hard to know if we are just throwing it away each time when what if there is something else going on inside. Every transfer my lining is perfect thickness.
    Last edited by Pieces; 17-10-2019 at 07:13.

  6. #6
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    I can only speak from my own experience with PCOS, obviously every PCOS woman will be different.

    Experience:

    2018:

    Two IUIs in 2018 - one resulted in a short-lived chemical pregnancy.
    Egg retrieval: 33 eggs retrieved, ICSI, only 3 survived the process. It is typical for egg quality to be impacted in PCOS women.

    2019:
    First transfer: BFN (likely because my body hadn't fully recovered from a bout of OHSS).
    Second transfer: chemical pregnancy
    Third transfer (final embryo): pregnant, currently almost 9 weeks.

    Between the first and the third transfer I spoke at length with my specialist about what needed to change in my medication regime. In the end it was that I needed A LOT of extra progesterone to sustain the pregnancy in the early weeks (which is again typical for PCOS women). I also requested that I was checked for endometriosis (negative) and NK killer cells (positive) so further medications were added to my regime. Like you, my lining was perfect every cycle and it seemed I was able to fall pregnant, but not stay pregnant.

    Without knowing your current medication regime, it's hard to know whether your specialist is on the right track and if you should be seeking a second opinion. Is seeking an alternative viewpoint something you can do without much fuss? Is your medication regime essentially the same as it was in the cycle that resulted in your daughter?

  7. #7
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    Quote Originally Posted by Toebeans View Post
    I can only speak from my own experience with PCOS, obviously every PCOS woman will be different.

    Experience:

    2018:

    Two IUIs in 2018 - one resulted in a short-lived chemical pregnancy.
    Egg retrieval: 33 eggs retrieved, ICSI, only 3 survived the process. It is typical for egg quality to be impacted in PCOS women.

    2019:
    First transfer: BFN (likely because my body hadn't fully recovered from a bout of OHSS).
    Second transfer: chemical pregnancy
    Third transfer (final embryo): pregnant, currently almost 9 weeks.

    Between the first and the third transfer I spoke at length with my specialist about what needed to change in my medication regime. In the end it was that I needed A LOT of extra progesterone to sustain the pregnancy in the early weeks (which is again typical for PCOS women). I also requested that I was checked for endometriosis (negative) and NK killer cells (positive) so further medications were added to my regime. Like you, my lining was perfect every cycle and it seemed I was able to fall pregnant, but not stay pregnant.

    Without knowing your current medication regime, it's hard to know whether your specialist is on the right track and if you should be seeking a second opinion. Is seeking an alternative viewpoint something you can do without much fuss? Is your medication regime essentially the same as it was in the cycle that resulted in your daughter?
    Thanks very much for your reply Toebeans. Sorry for my slow reply - I don’t get reply notifications. Congratulations on your pregnancy! So the Lucky no.3 stuck. I’m hoping my no.3 from this batch sticks too.

    My specialist will most likely looks into these things if I push from it. I don’t usually push for anything and I just go along with what she says. But I would like to check the NK cells and I guess I should check for endo too.

    The drugs I take are the same as with what I took for my daughter. Usually menopur, and decent amounts of progesterone 2x daily. Although my final transfer won’t be menopur as it’s too expensive in a FET.


 

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