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    Default Mthfr.....double gene

    Hi, i have been diagnosed with MTHFR. How do i manage this for preconception and conception?? Tia

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    Hi

    I have double MTHFR too.

    Ok, so you should avoid folic acid as your body can’t convert it well and it stops your body absorbing the natural folate in food. So make sure there’s no folic acid in your vitamins. I went full hog and switched my cereal and bread too as they were fortified with folic acid.

    Instead you’ll need to take the active forms of folate - methylfolate/MTHF or folinic acid - I take a mix of both. It’s also best to take these with the active forms of B6 (pyridoxal 5'-phospate or P5P) and B12 (methylcobalamin) to help absorption.

    Switch to a prenatal that contains these active forms. I use Eagle Tresos Natal available at good health food shops/chemists. Or you can buy Optimal Seeking Health prenatal or Thorne Basics prenatal online from the US.

    You should also speak to your doctor as MTHFR is also linked to clotting issues which can stop implantation or disrupt blood flow. So many ladies also take Clexane (a blood thinner) to help prevent that.

    Best of luck!

    R

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    Quote Originally Posted by Risa78 View Post
    Hi

    I have double MTHFR too.

    Ok, so you should avoid folic acid as your body can’t convert it well and it stops your body absorbing the natural folate in food. So make sure there’s no folic acid in your vitamins. I went full hog and switched my cereal and bread too as they were fortified with folic acid.

    Instead you’ll need to take the active forms of folate - methylfolate/MTHF or folinic acid - I take a mix of both. It’s also best to take these with the active forms of B6 (pyridoxal 5'-phospate or P5P) and B12 (methylcobalamin) to help absorption.

    Switch to a prenatal that contains these active forms. I use Eagle Tresos Natal available at good health food shops/chemists. Or you can buy Optimal Seeking Health prenatal or Thorne Basics prenatal online from the US.

    You should also speak to your doctor as MTHFR is also linked to clotting issues which can stop implantation or disrupt blood flow. So many ladies also take Clexane (a blood thinner) to help prevent that.

    Best of luck!

    R
    Thank you so much. I tried a bioceuticals vitamin and it made me feel sick. I had really bad heartburn. I don't kniw what it is but i tend to get it with the b vitamins. Any suggestions? Do the ones you recommended have a pale orange colour. They seem to be the ones that make me sick.

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    I take the Eagle Tresos Natal - black in colour with a slightly odd smell tbh, but never made me unsettled. That would be enough unless you’ve been told you need to be on higher dose folate.

    My FS insisted on higher dose folate so I add these ones:
    - Thorne MethylGuard Plus (active folate and active Bs)
    - Bioceuticals Folinic Acid

    I haven’t had any heartburn with these but I’m also not prone to it.

    R

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    Missmimi (12-03-2019)

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    Oh sorry just to add the Thorne ones are pale yellow/orange. The folinic acid is white.

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    Hi I am very confused after getting told by my FS and Ob saying I should take folate 5mg once a day for my compound heterozygous MTHFR gene mutation. But what my understanding is the over counter folate 5mg is folic acid which I should avoid. I m currently taking bioceuticals pre natal which include active folate but my ob want me to change to Blackmore pregnancy gold. And take folate 5mg... so I don’t know where can I get active form of folate for 5mg, does anyone know where can I get them?

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    I am compound heterozygous too. I switched to active folate.

    My FS also prescribed 5mg folic acid but I take active folate instead.

    The logic is that if you have MTHFR gene mutations you have a reduced ability to process folic acid so they ask you to take a higher dose of folic acid.

    Basically when we take folic acid our body needs to convert the synthetic folic acid into the natural form of folate found in food like leafy greens. That is where the MTHFR process comes in. But for those of us with the gene mutation/s we don’t convert it properly (eg we might convert only say 30% of the folic acid) leaving us with inadequate folate and higher risks of things like cleft palate. The traditional logic is if we take more folic acid then we will end up with enough. So they recommend 5mg instead of 800mg folic acid. Traditionally this was the only option as active forms of folate have only become available in recent years.

    There’s one problem with this approach. When we take folic acid it basically floats around in our blood stream on receptors. There’s only so many receptors available. So if we take high doses of folic acid we are blocking up the receptors with the folic acid, which we can’t use properly. And that may prevent the real folate we eat (say from spinach) from getting to a receptor.

    I personally believe taking extra folic acid is counter productive and I prefer to take active forms of folate. I think if you scroll up I’ve outlined what I take earlier on this thread.

    This is one of the times it’s a question of who to believe. Active folate has only been available recently so there isn’t the decades of studies on folic acid which is why you get mixed opinions from different specialists. My FS prescribed 5mg folic acid. I asked and she was fine with me taking active folate instead but still 5mg. That didn’t make sense to me. My reproductive immunologist insisted on active folate and said 1-1.5mg is sufficient. I take about 2mg as a compromise.

    R

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