@Sunshine14 firstly - I'm so so sorry about your failed DE transfers. It must be incredibly heartbreaking when you feel like you've gone the extra mile to find young eggs only to have them not stick!
I have no advice, I'm afraid as I'm
starting my DE journey in May, after three failed cycles but only to say welcome to the thread- it's very supportive and I hope that You find answers soon. Dr M is apparently amazing - I just had my first appt with him in December.
Fingers crossed for 2017
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31-12-2016 18:03 #821
High Natural Killer Cells #9
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01-01-2017 10:16 #822
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Hey sunshine14
I saw doctor m for implantation issues... no one was able to diagnose and doctor m did quickly and I went on to conceive (after lots of ivf and 8 years)
Baby is now 10 weeks old.
Doctor m diagnosed me with a t cell imbalance... so nothing could implant into my uterus.
He gave me meds and vitmains to improve my eggs
Vitmain e for uterus lining
Vitamin change for mthfr
For implantation pred, clexane and progesterone.
I somehow managed to fall naturally and hold baby till 5 weeks before meds started... no one really knows how.
If you have any questions happy to answer
Good luck and im so sorry
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01-01-2017 14:20 #823
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Hi Sunshine
Im sorry your having such a tough time, especially with donor eggs. I have the same as you basically - hashimotos, MTHFR, factor 5 leiden and nk cells. After my last failed fet with Dr M with a pgs tested blast he has requested HLA matches and im still chasing up the results but our next steps he said will be IVIG with possible LIT and neupogen. I have had 2 x IVF pregnancies lost and 3 bfn cycles all with immune meds but only last one with Dr M.
Do you have another consult with Dr M and your specialist coming up?
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02-01-2017 11:40 #824
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Thanks so much for your replies Velvet, Phia and ES02. It's certainly nice to hear that there may be a light in this tunnel. It's nice to know that dealing with Dr M is also the correct person. Thank you all
I am thinking of changing my fertility specialist as she hasn't really taken my concerns very seriously in the past. Our cycle before this last one my TSH was 16(!!) two days after the transfer which is a problem that I think should have been addressed and monitored. I want to be properly treated and monitored so I think it's best to try to go through Dr M only if I can.
I'm going to book in to see him at the next available appointment. I'm not sure when he opens again in the new year but I'll keep calling to try to get an appointment for as soon as we can get in.
I've also been reading about an endometrial receptivity array which can pinpoint the exact time your endometrium is receptive for implantation. Has anyone read about this or done this? From research, some women have a window where they need more days of progesterone or less days of progesterone for the embryo/s to implant and if you're outside of this window then the likelihood of implantation is severally impacted. Just something else to test for before our next cycle. At this stage I want to know what we are dealing with and treat everything before going through this again
I hope you are all having a lovely start to 2017 xx
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02-01-2017 17:05 #825
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A new specialist another opinion is always helpful. Being that hypo post transfer cannot be a good thing, in saying that my endocrinologist will never test thyroid function in the middle of a cycle as stims/estrogen can temporarily elevate your TSH so she doesnt feel its useful information. Ive just tested every 6 weeks for the past 2 years during ivf bit never in the middle of a cycle and that helps us keep track of things. Do you have an endo?
Ive heard of an ERA and it might be worth considering if your showing no signs of implantation, its a simple procedure. Perhaps Dr M might weigh in his thoughts when you speak to him.
Im going to call again this week to try follow up our last bloods. I know there in and I rang several times and reminded them late last year so we can plan our treatment for this year but I still am chasing them 😥
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03-01-2017 17:15 #826
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High Natural Killer Cells #9
Hi all, just been discharged from Primary IVF after my dating scan showed I'm 7 weeks and 3 days pregnant and all is looking good. Upon discharge my FS said to stop the Clexane, Progesterone pessaries and to half my 25mg Prednisolone for a week and then stop. I'm a bit concerned this might lead to miscarriage as I read that you're supposed to continue the Bondi Protocol until 12 weeks. I went to see my GP who agreed to stop everything. I don't know what to do. Any advice would be greatly appreciated. (We have a full DQ match, I have high natural killer cells and will be 40 next May. Been TTC for 2 years.) Thank you!
Last edited by KittyCat; 03-01-2017 at 18:18.
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03-01-2017 18:16 #827
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@KittyCat congratulations!!! You must be thrilled!!
my clinic suggests stoping clexane after the7 week scan. Prednisolone they say to decrease by 5mg every 5 days i.e.: tomorrow drop to 20mg for 5 days then 15mg etc that way you're weaning off slowly and would take approx 3 wks so you'd be approaching 12wks. As for progesterone I would stay on it until 12wks definitely, wait until the placenta kicks in & takes over for you!
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03-01-2017 18:22 #828
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Hi munchkin14, thank you for the response. Yes, we are thrilled because every doctor we saw said we had no chance and to look into sperm donor or surrogacy! Okay I'm more comfortable with that (weaning off the Pred slower than what the FS at Primary suggested). I'm worried about stopping the Clexane though as it forms part of the Bondi Protocol. When your clinic gave you this advice, this was for NKC right?
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03-01-2017 20:55 #829
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Congrats kittykat
Doctor m had me on pred and clexane to 16 weeks from memory theb added asprin
Progesterone was closer to 18 weeks.
So no i wouldnt be stopping
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03-01-2017 21:53 #830
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