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  1. #1
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    Default Does anyone have MTHFR A1298C mutation???

    Hello all. I have one beautiful healthy 17month old daughter but have suffered a second devastating miscarriage, this time sadly in the second trimester.

    I have just received post mortem and blood results and the only thing they found was that I have a homozygous mutation for the A1298C variant of the MTHFR gene.

    Is it possible that this may have been a reason for my miscarriages and if so how?

    I have googled but am still confused and want to ask if anyone else suffers from this and can shed some light, give advice, recommend specialists/naturopaths and provide any info on how to make this gene work better to avoid health issues and help me to conceive a healthy successful pregnancy...... please. Thank you.
    Last edited by VioletMay; 05-07-2016 at 22:19.

  2. #2
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    Bumping for you hun x

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    VioletMay  (07-07-2016)

  4. #3
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    I have mthfr but an heterozygous c1677t. My ob picked it up when i was pregnant with my son but we did end up losing him when i was 18 wks preg. All up ive had 1 successful preg and 8 losses. Naturopaths are your best place to start and there are sone groups on fb. There are other tests your naturopath may get you to do. Basically mthfr cant process folic acid so we need to take it in its natural form. Elevit and other preg supps are of no use to us. Other tests related are if you can process the b vitamins correctly and some others i cant remember. I was lucky my ob did these tests but he said he didnt know a lot about it and i now see a naturopath. The fb pages can recommend some naturoparhs for you in your area

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    VioletMay  (14-07-2016)

  6. #4
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    Thank you very much for replying and the information. I have an over the phone appoint with MTHFR Support in Sydney tomorrow. Thank you for shedding some light.

  7. #5
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    I have have hetro compound and have a healthy baby girl. I was on clexane, asprin and methyfolate

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    VioletMay  (14-07-2016)

  9. #6
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    @Miss.Glitter thank you. Did your ob put you on clexane and methyl folate? My ob didn't think I needed anything.

  10. #7
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    Hi,

    I'm so sorry to hear of your tough time conceiving.

    Did the phone appt give you anymore information?

    I have compound heterozygous, and had two miscarriages at 6 weeks prior to baby number one, and this time around, two miscarriages at 10 weeks, and currently 33 weeks pregnant. My OB didn't want to blame them on the MTHFR mutations, couldn't say one way or another. However was happy to put me on progesterone and clexane for the first trimester anyway. And high dose folate (but I took methylfolate after doing my own research).
    Would your OB be willing to give the clexane a go when you fall pregnant again? Or is flat out saying no?

    Good luck and all the best for a healthy successful pregnancy.

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    VioletMay  (14-07-2016)

  12. #8
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    I'm getting this test tomorrow actually I had preeclampsia and delivered early in January. I've also had a miscarriage. I'll let you know if I have it when I get the results back.

    I'd definitely speak to a naturopath who has experience in it. Good luck

  13. #9
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    I would urge you to please see a medical specialist about this before you think about going to a naturopath.
    MTFHR mutation is very common, most of the population have it but most people are unaware of it. There are medical professionals that deal with this issue specifically as the issue is a very, very wide one with lots of variants.
    Please ignore the wild claims and prescriptions made online. They're primarily false and are not supported in any way by science (and some with no evidence at all). For example, methylfolate can be quite dangerous for some people and is not the automatic prescription for those with a mutated MTFHR gene.

    If you are unclear, speak to your doctor who can refer you for a more detailed explanation at which point you can divulge a targeted strategy if need be. Some hospitals also have 'multiple miscarriage' groups that also inform and refer.
    Last edited by Mrs Tickle; 13-07-2016 at 22:01.

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    VioletMay  (14-07-2016)

  15. #10
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    I should clarify that my ob was happy for me to take folate in either form, be it folic acid, folinic acid or methylfolate.

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    VioletMay  (14-07-2016)


 

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