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  1. #1211
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    @tuxcat that's great news that the follies are a similar size.
    for the dynamic duo.

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  3. #1212
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    I found a full article (rather than extract) that talks about mosaicism. Makes me wonder about PGS. Here are some quotes. Link to the article is at the bottom of the page.

    high rates of numerical chromosomal abnormalities were also found in embryos from young women suggesting that these abnormalities are not exclusively related to maternal age

    These potentially viable embryos are discarded, thereby lowering the number of viable embryos in an IVF treatment. It seems logical to assume that this results in an overall decrease in live birth rates. It is clear, however, as previously suggested (Vanneste et al., 2009a), that one of the rationales behind cleavage stage PGS, i.e. that the biopsied cell is representative for the entire embryo, is incorrect.

    Indirect evidence supports the idea that diploid–aneuploid mosaic embryos are viable.

    http://humupd.oxfordjournals.org/content/17/5/620.long

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  5. #1213
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    Quote Originally Posted by Green lady View Post
    Lucrin trigger was my choice as I just wanted to change something in the hope it gave me a better outcome. Doing luveris and Gonal f was also my choice for the same reason. I think my eggs are just all crap and no protocol change is really going to fix that. Feeling ok just hoping to have something to biopsy on day 5 or 6.

    You don't know that it hasn't given you a better outcome yet Luv. Ok, on the face of it regarding egg maturity/fertilisation rates, it may seem like a worse result but the proof of the pudding will be when you get to Day 5 and see how many can be biopsied/frozen.

    Of course, I'm hoping they'll all be either good enough to biopsy or freeze, but even if the usual 50% drop off rate happens, having 3 to biopsy would be an excellent outcome I reckon!!

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  7. #1214
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    Quote Originally Posted by faithandhopellove View Post
    I found a full article (rather than extract) that talks about mosaicism. Makes me wonder about PGS. Here are some quotes. Link to the article is at the bottom of the page.

    high rates of numerical chromosomal abnormalities were also found in embryos from young women suggesting that these abnormalities are not exclusively related to maternal age

    These potentially viable embryos are discarded, thereby lowering the number of viable embryos in an IVF treatment. It seems logical to assume that this results in an overall decrease in live birth rates. It is clear, however, as previously suggested (Vanneste et al., 2009a), that one of the rationales behind cleavage stage PGS, i.e. that the biopsied cell is representative for the entire embryo, is incorrect.

    Indirect evidence supports the idea that diploid–aneuploid mosaic embryos are viable.

    http://humupd.oxfordjournals.org/content/17/5/620.long

    Very interesting Luv

    Mosaicism can happen when you have CVS/Amnio done too. In regards to the PGS, they need to do more study (perhaps with the mice) where they transfer these embryo's and if a pregnancy occurs, what % of the fetus's would be affected by some kind of chromosomal abnormality???

    Either that, or maybe whomever the embryo/s belong to should be given the option of keeping them on ice and transferring them knowing that there is a risk that they could have chromosomal abnormalities???

    Unfortunately, PGS etc isn't an exact science, they just do the best they can with what they know. I'm sure more advances will be made in the years to come.

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  9. #1215
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    Quote Originally Posted by winsor View Post
    maybe they'll find some more on RHS next scan/at EPU. yes, hoping they're great quality.

    going slowly at EDA. I got excited when I received an email from someone but they were just saying hi which was nice. at least it confirmed the message function works. I pop in every day or so apart from when I was away, but don't feel that comfortable there yet. will see how it goes. could take a while I guess. I've never been that good at small talk. and for some reason my threads don't appear in 'recent activity' link even when they've had posts. so probably flying under the radar if anyone is watching anyway. I just want to be pg again & have the healthy bub. all the waiting & out of my hands parts is hard to manage. at least when it's OE you can set the timeframe so that's one part you can control even if the result is out of your hands
    @winsor The 'donors looking for recipients' thread doesn't appear in active topics (but the meet and greet intro does), if that's what you mean? I found the easiest thing to do was to get to know a few other recipients and not to try to post to everyone (unless you are very good at small talk!), too easy to lose track. I especially try to keep in touch with anyone that has similar sense of humour or whatever.

    Quote Originally Posted by faithandhopellove View Post
    I found a full article (rather than extract) that talks about mosaicism. Makes me wonder about PGS. Here are some quotes. Link to the article is at the bottom of the page.

    high rates of numerical chromosomal abnormalities were also found in embryos from young women suggesting that these abnormalities are not exclusively related to maternal age

    These potentially viable embryos are discarded, thereby lowering the number of viable embryos in an IVF treatment. It seems logical to assume that this results in an overall decrease in live birth rates. It is clear, however, as previously suggested (Vanneste et al., 2009a), that one of the rationales behind cleavage stage PGS, i.e. that the biopsied cell is representative for the entire embryo, is incorrect.

    Indirect evidence supports the idea that diploid–aneuploid mosaic embryos are viable.

    http://humupd.oxfordjournals.org/content/17/5/620.long
    @faithandhopellove cool, I'll check it out

    @green lady I feel your pain, my drop off rate from day 1 to day 5 was 70-90% so anything less than a good haul of 8 or so used to have me despairing. Ack, its just difficult to see numbers culled so quickly. Fingers crossed the ones remaining have benefited from the different protocol.

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  11. #1216
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    Quote Originally Posted by faithandhopellove View Post
    I found a full article (rather than extract) that talks about mosaicism. Makes me wonder about PGS. Here are some quotes. Link to the article is at the bottom of the page.

    high rates of numerical chromosomal abnormalities were also found in embryos from young women suggesting that these abnormalities are not exclusively related to maternal age

    These potentially viable embryos are discarded, thereby lowering the number of viable embryos in an IVF treatment. It seems logical to assume that this results in an overall decrease in live birth rates. It is clear, however, as previously suggested (Vanneste et al., 2009a), that one of the rationales behind cleavage stage PGS, i.e. that the biopsied cell is representative for the entire embryo, is incorrect.

    Indirect evidence supports the idea that diploid–aneuploid mosaic embryos are viable.

    http://humupd.oxfordjournals.org/content/17/5/620.long
    @Faithandhopelove - I have read similar studies which i think is the reason for the move more recently to blastocyst PGD/ PGS rather than going it at day 3 or cleavage stage. Doing the biopsy of cells from a blastocyst is supposed to give a more accurate result on the abnormality.

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  13. #1217
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    Quote Originally Posted by BlondeinBrisvegas View Post
    You don't know that it hasn't given you a better outcome yet Luv. Ok, on the face of it regarding egg maturity/fertilisation rates, it may seem like a worse result but the proof of the pudding will be when you get to Day 5 and see how many can be biopsied/frozen.

    Of course, I'm hoping they'll all be either good enough to biopsy or freeze, but even if the usual 50% drop off rate happens, having 3 to biopsy would be an excellent outcome I reckon!!
    With a starting point of 6 to be honest I will be happy if I get one to biopsy@BlondeinBrisvegas

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  15. #1218
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    Quote Originally Posted by Green lady View Post
    @Faithandhopelove - I have read similar studies which i think is the reason for the move more recently to blastocyst PGD/ PGS rather than going it at day 3 or cleavage stage. Doing the biopsy of cells from a blastocyst is supposed to give a more accurate result on the abnormality.
    I would love to read the article on self correction of chromosomal abnormalities as that refers to "later stages of growth" but I can't find a free full article. I would have access at work but won't be there until Friday next week when I am acting manager (too useless to do anything else now). I find the idea that aneuploid cells in mosaicism might be overcome by their own deficiencies and diploid ones continue to be very hopeful (I have 3 untested frosties so any bit of hope is precious to me).

    Ah, hope working on a weak mind perhaps.

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  17. #1219
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    Quote Originally Posted by Green lady View Post
    With a starting point of 6 to be honest I will be happy if I get one to biopsy@BlondeinBrisvegas
    Ok Luv...lets meet in the middle & go for a "Pigeon Pair"....Deal??😊

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  19. #1220
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    Quote Originally Posted by faithandhopellove View Post
    I would love to read the article on self correction of chromosomal abnormalities as that refers to "later stages of growth" but I can't find a free full article. I would have access at work but won't be there until Friday next week when I am acting manager (too useless to do anything else now). I find the idea that aneuploid cells in mosaicism might be overcome by their own deficiencies and diploid ones continue to be very hopeful (I have 3 untested frosties so any bit of hope is precious to me).

    Ah, hope working on a weak mind perhaps.
    Yes....have heard about the self correction thing. That happens in a way now doesn't it when they thaw frosties??

    Sometimes they lose a couple of cells in the thaw then regenerate them again don't they??

    It's the same sort of deal or no???😐

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