I've been reading a lot about PGD testing in HB and most ladies recommend doing it (better chances to get a positive apparently?)
Where can we have the embies tested if our clinic don't do it? Can you explain me what's the difference between PGD and PGS and which one would be more suitable? I'm guessing for what I've read both must be expensive (750 per embie), and that they are an out of pocket expense 😩
Even though I've been through three full cycles, I still feel a rookie 😬
Thank you in advance!
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17-01-2016 00:37 #1
Where to do PGD?
17-01-2016 07:01 #2
17-01-2016 08:24 #3Senior Member
- Join Date
- Nov 2015
@Kookii does your clinic have an affiliation with one of the bigger clinics that does PGD? I'd explore that avenue first. I must admit I haven't heard that you can do PGD if your clinic doesn't offer it, but worth investigating.
From my limited understanding, some clinics seem to use PGS and PGD interchangeably, but PGS is a screen (95-98% accurate) and is done on day 3 embies, whereas PGD is 100% accurate (I believe) and done on day 5 embies. It's about the number of cells they can remove from the embie and the testing process - at day 3 it's only 1-2 cells, whereas by day 5 they can take more cells out of what will become the placenta and therefore do a more thorough examination (with reduced risk to the embie - although both PGD and PGS carry some risks). My FS prefers day 5. With day 3 you can do a fresh transfer, but with day 5, embies are frozen and results take 3 or so weeks. There are also different versions of day 3 PGD/PGS and some are more thorough and are called PGD, although even the most thorough don't go over 98% accuracy. A further advantage of day 5 is that given a lot of embies succumb before day 5 generally, therefore there are less to test and you don't waste money on testing embies that wouldn't have made it to day 5 anyway. That said my clinic charges a base fee for up to 4 embies - over $3K...
Also, it's worth bearing in mind that a PGD normal doesn't guarantee a BFP. We transferred a normal last cycle that didn't take and you'll find many other women on here who have had the same experience.
Have you you considered or gotten a second opinion? My rule going in was that after 3 stim cycles I'd get a second opinion, which we've done and we've realised that we had no chance with FS#1. We'll stick with FS#2 for the rest of our journey.
Good luck and I hope some more knowledgable ladies can add some extra info. Maybe pop over to the PGD thread and post your question there too?
17-01-2016 09:40 #4
Thank you @Gagingi!! That's what I needed to know.
We are going for our 4th cycle, and we have already changed FS, I totally understand what you say. For us was a game changing but this a low cost clinic ergo why they don't do PGD.
Our problem is severe male infertility, in three cycles we got only three embies and one of them barely got to day 5; I reckon that's why my former clinic didn't offer to test them. I tick all the boxes: more than 35, more than 3 cycles and no pregnancy, etc.
I'll ask my FS next time, It may worth a shot! First let's hope that we get more embies next cycle (fingers and toes crossed).
Thank you again!! Super appreciate it. Xx
17-01-2016 16:03 #5Senior Member
- Join Date
- Nov 2015
I'm glad it was helpful @Kookii. With DH do they do HA-ICSI/PICSI? We found that increased our fert rate by 20% and number of day 5s x 4. I know the low-cost clinic associated with our clinic doesn't do PICSI, which is one reason we need the expensive one.
17-01-2016 20:51 #6
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