Thanks so much @ladybug14, congratulations on your belly bump too Well, Dr M and Wazza are both very reputable specialists so I guess I just gotta trust that the chance of it causing problems really are that minimal ....all the best for your upcoming scan Xx
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20-12-2014 17:21 #121
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20-12-2014 18:30 #122Senior Member
- Join Date
- Aug 2014
Omg @MGCbertie - massive congratulations!! What brilliant news, you must be over the moon. Well done for your determination to keep going. Wishing you great numbers on Monday, you already have a nice P4 level! So chuffed for you.
As for the prednisolone question, I am on the same dose, 25mg, currently 12 weeks & had the same concerns, and also just desp to come off it as it has made me so puffy, but Dr M told me it does not cross the placenta & only works on the mother's side? He won't give me a date to come off it yet, he said it's different for each case & depends on blood testing etc. Anyway, I also think the minimal cleft lip risk is outweighed by feeling supported to carry the pregnancy to term. I really feel like the only reason I am pregnant right now is due to the immune drug support. So I will stay on everything as long as advised. It is scary being on so many drugs though, I understand.
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20-12-2014 20:23 #123
@MGC Bertie - congrats!!!
@Ladydee With dr M I was on 35mg prednisolone for my first pregnancy, fully weaned by 26wks. This time around I was on 20mg, fully weaned by 25wks. Both pregnancies I've been diagnosed with gestational diabetes - my endocrinologist doesn't believe they are true cases as pred really messes with your blood sugar levels but we obviously have to manage/treat it anyway.
Dr M says it's best to be completely weaned for at least 3 wks before going for GTT, so keep that in mind as your Ob requests that test usually between 24-28wks.
21-12-2014 01:08 #124
Ladies, on the steroids, you just have to make sure you are taking extra folate, calcium and magnesium when on steroids and it is supposed to help with the side effect. Yes pred doesn't cross the placenta but dex does which is why you're swapped over once you get pregnant.
Congrats again MGC Bertie. I am so happy for you xxxx
21-12-2014 13:10 #125
21-12-2014 14:35 #126
High Natural Killer Cells #6
Thanks heaps @Legwarmer, @Bella978 and @Chiefsgirl .... You girls give me some much needed hope that we might actually be in with a chance this time! I've got my first scan on Tuesday which is the same day of year, last year, that I found out about my first loss via a scan.....let's hope this Christmas is a polar opposite to last one for me as I was miscarrying on a flight to Adelaide, it was a nightmare
@Bella978 - that's really interesting to learn about the GD risk thanks. During my bit of "Dr Googling" about Pred, I've never come across that bit of info. I've got PCOS and a family history of diabetes so I'm in the higher risk anyway but I'll see if I can manage to get my GTT test done after I've been weaned off the Pred. I wonder if my 1500mgs/day of Metformin would counteract that at all? Are you or have you been on Met?
Last edited by Ladydee; 21-12-2014 at 14:42.
21-12-2014 14:59 #127Senior Member
- Join Date
- Jun 2013
Hi Ladies - I haven't been on here for some time so some of you may not even remember me. Firstly a huge congratulations to all those that are pregnant and a special congrats to MGC Bertie - I remember you from when I was more active here. Fantastic news - loved your story of your Mum taking part of the phone call and your Xmas party and all the comments about chocolate and pregnant women. I truly hope you have a smooth pregnancy, you really deserve it.
I thought maybe I should update that I've finally achieved a BFP too and wanted to give you hope. But, I also know how hard that can be to dig deep and find it. I really didn't have anymore left 6 months leading into this cycle and often felt guilty about that too.
I'm very similar to MGC Bertie, where after 5 years of ttc, I only got a low HGC once - in April this year of 18 and then it was gone I thought I was on enough meds then. Thryoxine, Metformin, Humira x 2, LIT x 2, 20mg Prednisolone, 60mg Clexane - but obviously I wasnt. This was with a proven ED and very good embryos.
3rd trip overseas and we struck gold on November 21st - we transferred 3 from requesting to thaw all 6 to select the strongest (a big call, but it was our last shot). 1 took, we had the heartbeat scan on Friday just gone and it was strong at 138 and measuring 6mm. After so long and never getting so much as a 2nd line on a pregnancy stick - its starting to sink in and touch wood it continues.
I'm not sure what made the difference this time. I too didn't bother with acupuncture this time (once after transfer, but thats it - I cant really afford it and justify it anymore).
I did eat Paleo 70-80% of the time, 3-4 months prior and lost 8kg - not that I was that much overweight before @ 68kg. (I call it extreme Gluten free).
I also consulted with Repromed in Adelaide and attacked my adneymoyisis that all songraphers and FS's have skimmed over, saying I have it, but no big deal. I had 3 zoladex implants (1 per month) and then on daily lucrin injections for the last 2-3 weeks - so I effectively down regged for nearly 4 months. It halved my utuerine volume - a good thing, as they had said it was quite high.
I have been also on metformin and thryoxine the whole way through since April, but not sure if this really makes that much difference to be honest.
This time, I went back on dex (have had before with Dr Matthias and activity was calm after a failed transfer last November). Dose, 1.5mg 3 weeks prior, 2mg after transfer. IVIg 11 days prior and then a few days after the positive. Neupogen 3 weeks prior based on 63kg (63mcg - 21 units daily). Baby asprin, I started taking 2-3 months prior.
I think thats it - but I just wanted to share that with you, as I know I always like to know what everyone is on. I really went around in circles on what to do, how long to take everything, even down to, should I take crinone or pessaries - thats how much I questioned everything. It drove me nuts!
Oh, I also took doxcy antibotics 10 days prior and also was on 1 x PIO injection (Gestone) and 2 x crinone from day of transfer. Dr M always says to double what the clinic was perscribing. My progesterone is sitting around 148-160. I read somewhere, I cant remember where... that keeping progesterone levels high calms inflammation.
Sorry for the long post and for popping in unannounced, I really just wanted to share what worked out of all that for me - and to be honest I'm not really sure! Dexamethasone I think makes a huge difference for me. I have high CD56/57 NK Cells and I heard dexa is better at stopping these in their tracks - but apparently IVIg can be too? I also have very high cytokines (found out from overseas testing - were sitting at 43.9 - should be under 30) and they were at this level 2 months prior to this cycle. I havent tested again so not sure where they are now.
21-12-2014 18:08 #128
Just popping in after a weekend away...
YAY!!!! MGCBertie Amazing news, I am so super happy for you. With AI as well, gives me hope for a natural BFP whilst waiting...
My update I ended up with 6 embies suitable for CGH testing (our equal best) Because of my translocation I can only expect 1-2 'normals'
Planning transfer in Feb / Mar. Have just done all the HLA matching tests for Dr M. Anyone remember how long the results took? I suppose I will be chasing G in the New Year....
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MGC Bertie (21-12-2014)
21-12-2014 21:10 #129
21-12-2014 21:50 #130Junior Member
- Join Date
- Oct 2014
@MGC Bertie that is fabulous news ...
I hope that you can really enjoy and celebrate it ... it is so hard to let go of the anxiety ... but you so deserve to enjoy this amazing breakthrough ...
We are waiting to see tomorrow Day 5 how many if any of the 8 embies are suitable for PGD ... but I a feeling remarkably relaxed ...
I am relieved to hear a few rumbles about Dr M ... he is obviously one of the leaders in the field but his practice could do with an overhaul ... I think I am going to go to my appointment with him for biospsy results next week with a long list of questions ... the two previous times I feel I have left with inadequate
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MGC Bertie (22-12-2014)
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