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  1. #1
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    Post Positive ANA ( antinuclear antibodies )...does anyone have any experiences?

    Hi Everyone

    I am on my 3rd cycle of IVF and have been diagnosed with a positive ANA. I believe it has something to do with high immune system in my body and it is rejecting pregnancies. I was fortunate enough to get pregnant both times but miscarried at week 8 and week 4.5. I am devastated and starting to lose hope and wondering if anyone has positive ANA and still conceive a healthy baby?

    I would be much appreciated if anyone could share any thoughts or experiences.

    Thank you

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    Hi Babychino

    Yes, I have elevated ANA:

    2010 = 1:40
    2011 = 1:60
    2012 = 1:640

    Due to the huge jump from 2011 to 2012, my FS sent me to an endocrinologist to explore possible underlying illnesses; eg Lupus etc. I didn't have any illnesses and my elevation can be put down to age.

    IVF/ICSI did not work for me due to my old eggs, hence I went the donor egg route. My FS treated my ANA with Clexane, Prednisolone, Cardiprin and an Intralipid Infusion.

    If you would like any more information, feel free to PM me. My boy is only 3 weeks old and keeps me very busy, so there may be a delay in my reply but I will always get back to you.

  3. #3
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    Babycino..... just to let you know that there's a very active thread on here about Natural Killer Cells that you should check out (sorry I don't know how to link it). Many of the women on that thread have high ANA (like I do) along with other immune issues. I'm on the same treatment as Sunny15 - this is our "third time lucky" with Dr M's immune protocol, this time we're sing my sister's DEs, so hoping everything combined will pull us over the line. Definitely check out threads with "Natural Killer Cells" or "Dr M" in it (Dr Mattias)

  4. #4
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    Yes, it's officially a BFN again, as expected.

    I got the nurse to also test my TSH level and it's gone down to 0.7. Sounds good (since the aim is to be between 1-2) but considering 5 weeks ago it was 5.4, then 3 weeks ago 12.4 and now 0.7, it definitely sounds like something that I need to get stabilised before doing an FET.

    First available appointment for FS is in 3 weeks time, and first available appointment for Dr M is 5 weeks. I asked to go on both cancellation lists, as really don't want to wait for either that long. Thinking of sending them both emails, explaining what else I want tested, and what meds I'm thinking of doing next. Also going to make an appointment for my endocrinologist tomorrow, though usually he's months is advance too!

    On a side note, this afternoon's nurse, mentioned that Prof I is now also prescribing Prednisolone for immune issues (along with aspirin and Clexane), so it's interesting that he's coming over to this belief.

  5. #5
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    Quote Originally Posted by Babychino View Post
    Hi Everyone

    I am on my 3rd cycle of IVF and have been diagnosed with a positive ANA. I believe it has something to do with high immune system in my body and it is rejecting pregnancies. I was fortunate enough to get pregnant both times but miscarried at week 8 and week 4.5. I am devastated and starting to lose hope and wondering if anyone has positive ANA and still conceive a healthy baby?

    I would be much appreciated if anyone could share any thoughts or experiences.

    Thank you
    Quote Originally Posted by MGC Bertie View Post
    Babycino..... just to let you know that there's a very active thread on here about Natural Killer Cells that you should check out (sorry I don't know how to link it). Many of the women on that thread have high ANA (like I do) along with other immune issues. I'm on the same treatment as Sunny15 - this is our "third time lucky" with Dr M's immune protocol, this time we're sing my sister's DEs, so hoping everything combined will pull us over the line. Definitely check out threads with "Natural Killer Cells" or "Dr M" in it (Dr Mattias)
    Hi MGC Bertie

    Thanks for your reply, I cant find to see the link anywhere!

    Does anyone know how I can get on to the link mentioned above??

    Thank you!

  6. #6
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    Babycino.... I've tried again but can't work out how to link it. The name of the thread is called "High Natural Killer Cells #4" so try putting that in the search. Each time it gets to about 1000 pages long, they make a new thread, so if you find #1, #2 or #3, then just go to the last page of those ones to link to the next oe, and then you'll eventually get there. Sorry I can't be of more help - technical stuff is not my forte!!

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    I have high ANA due to Rheumatoid Arthritis.

    We used heparin, prednisilone, asprin, extra progesterone pessaries...finally got our sticky bub on the cycle that we used it

    Def get a specialist that will communicate with your endo...and good luck. It can happen....now you know what you are dealing with, hit it as hard as possible.

  8. The Following User Says Thank You to River Song For This Useful Post:

    MGC Bertie  (27-05-2014)

  9. #8
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    Quote Originally Posted by River Song View Post
    I have high ANA due to Rheumatoid Arthritis.

    We used heparin, prednisilone, asprin, extra progesterone pessaries...finally got our sticky bub on the cycle that we used it

    Def get a specialist that will communicate with your endo...and good luck. It can happen....now you know what you are dealing with, hit it as hard as possible.
    Thanks for the reply River song, would you mind telling me what dose you are on for predisolone and progesterones?

  10. #9
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    MGC Betie : I found the thread! Thank you!!!

  11. #10
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    Quote Originally Posted by Babychino View Post
    Thanks for the reply River song, would you mind telling me what dose you are on for predisolone and progesterones?
    progesterone pessaries every day through to 12 weeks.

    Prednisolone was 5mg i think....1 tablet morning and night

    Heparin - again, i think was 2mg - 1 injection every day from collection to 18 weeks

    Our dd is now 3 1/2....we had a difficult pregnancy but she made it and so did i.

    Hang in there <3


 

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