High Natural Killer Cells #4

[bbhope]

Welcome hope. When u said immature embies, what did u mean by that? They didnt grow to day 5?

Please forgive my ignorance. Expert ladies here can answer. Isnt that attack of NK cell only happen when the embie implants in the womb but not in the lab? Hope, from what u r describing, it sounds like an egg issue. But you do have the gene that relates to immune issue. Further testing is worth pursuing on this end. I know someone who has this condition and delivered a baby with only aspirin and prednisolone treatment. But DrM is probably expert on this end if more aggressive treatment is needed.

[hope168]

Thanks for the replies girls.
@soclose -- I think egg quality is on the low side, AMH @ 9 (Dec 2013), AFC @ 7 (Jan 2014), given most of our eggs have been immature. What is the difference between egg donor and embryo donor? Do you mind if I ask about the cost and procedures for this?
@bbhope -- I had to look up immature eggs as well, seemingly means the chromosomes are not in order. This is prior to fertilization.

I am not sure if the batch of eggs that we are born with contain, good, bad, immature ones. Or, we can still do anything about it. My naturopath insist I see Dr. M, but, I am on the fence as, I am on the same understanding as you, bbHope, I can't even get past the egg transfer stage for NK cells to "attack".

Thanks.

[Nidhulaine]

Thanks for the replies girls.
@soclose -- I think egg quality is on the low side, AMH @ 9 (Dec 2013), AFC @ 7 (Jan 2014), given most of our eggs have been immature. What is the difference between egg donor and embryo donor? Do you mind if I ask about the cost and procedures for this?
@bbhope -- I had to look up immature eggs as well, seemingly means the chromosomes are not in order. This is prior to fertilization.

I am not sure if the batch of eggs that we are born with contain, good, bad, immature ones. Or, we can still do anything about it. My naturopath insist I see Dr. M, but, I am on the fence as, I am on the same understanding as you, bbHope, I can't even get past the egg transfer stage for NK cells to "attack".

Thanks.

hi yes the NK cells only come into play when embryo is trying to implant and either prevent implantation or cause miscarriage.
Egg donation is where u get eggs from a donor (South Africa is popular) and fertilise them with your partners sperm. If however there is a sperm issue as well then embryo donation where both the egg and sperm have come from other people and have formed embryos. Has your partner done a sperm fragmentation test? It tests the quality of the actual DNA within the sperm and not just counts and morphology.
with regard to Dr M I would get him to run some tests and check you out. Having MTHFR can often mean you have other things you are unaware of. The other thing is he has a huge amount of experience and will very quickly tell you whether he believes you will be able to get pregnant with your own eggs.

[hope168]

Thanks Nidhulaine.

hubby has done sperm analysis. His morphology isn't great, but from what I remember, his DNA fragmentation was OK.

It's been quite a journey, TTC since 2010. Trying, investigating, looking for answers, looking for direction.

I've got Dr.M booked for mid Sept.

[Miss Sagi]

Hope168, welcome... it's sounds very odd that you've had so many immature eggs with most of your cycles. I thought if they're immature they haven't been grown out enough? I'm sure Professor Nidhulaine would know...haha she's the walking encyclopedia of IVF.

Just to add confusion to the mix, I'm choosing my own egg donor and sperm donor rather than going for an embryo. I call it my designer embryo!

[Miss Sagi]

Soclose, I put the call out regarding IVIG in SA on the egg donor forum but no responses yet.

[Miss Sagi]

Hope168, the girls are right, Dr M is the best person to assess you. General consensis is if you have 1 immune issue you will have at least 1 more.

[hope168]

missSagi -- may I ask if you are managing your MTHFR homog?

Thanks! I guess I'll be keeping my appointment with Dr.M. I haven't gone to download the forms prior to seeing him. I have an inch thick worth of test results complied from over the years to copy for Dr. M. Did you find a lot of input from the first appointment, or, was it "here's a bunch of more tests for you" and talk to you in a few weeks?

I guess I am being slightly impatient now, so many tests undergone and, still looking for reasons why.


Thanks.

[bbhope]

It depends on what you have provided to DrM. My FS ordered a heap -- 10 +vials BT for implantation screening. These also include some immune stuff. I bet she would have ordered more after seeing my result. But then, i decided to pass onto DrM for second opinion before seeing FS again. DrM wanted to repeat some and do a couple more. It was like 5 mins phone conversation and then waited another month for me. I was in no rush since I wasn't ready for the next cycle. Both FS and DrM wanted me to do uterine biopsy in the end.

Ya the waiting can be a pain.

[Galea]

Always with the waiting sigh. Waiting and testing..... and other people getting bfps.... im not feeling negative at all