Gosh - I just thought of something important to add - but by the time I opened up the thread I had forgotten already - will try and think of what it was. It was possibly a question.
Trying the misoprotsol first this time again - they're now combining it with another drug that increases its success rate from 60-80%. Hoping it works.
Edit: I remembered!!! Wonders will never cease. The other thing that doesn't make sense is why we had three successful pregnancies first with no problems and are now having problems. I did have a bleed with our 3rd at 15 weeks and was tender for about a month afterwards, but no signs of problems in the uterus - they put it down to a small placental abruption.
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30-08-2013 20:28 #11
Last edited by Little Ted; 30-08-2013 at 20:30.
31-08-2013 02:20 #12
LT, in reading all of that I wonder about the benefit of bringing some order to all the different pieces of info you have by getting a recurrent mc specialist involved. An FS who specialises in this area will be able to work with you BEFORE your next BFP and consider all of the important elements together such as egg quality/ the uterine environment/ factor v etc. They will also be able to support you and monitor the pregnancy closely till handing over to your OB so you have continuity of care.
The use of clexane is pretty widespread by FS who deal with recurrent loss (regardless of factor v) and if it is a clotting issue as you suspect thinning the blood can only help.
I agree it is a positive sign that you already have had successful pregnancies but the suspected placental abruption would make me question the integrity of the uterine environment and possibility of scarring or patchy endometrium? Anyway I know we've had this discussion before given your history of D&C's.
Good luck with the misoprostol hun. I hope you can move on swiftly with good support and your sticky BFP is just around the corner xx
* Have edited this post as have been thinking about your situation during breast feeds overnight
Last edited by Starf1sh; 31-08-2013 at 06:12.
31-08-2013 07:17 #13Senior Member
- Join Date
- Mar 2013
Hi little ted, sorry you are going through this. So heartbreaking! Xxx I was in a similar situation, had one baby and had 3 mcs since buy I am now 14 weeks and everything is looking good this time. I saw a reproductive immunologist is Sydney (also does phone consults) and he diagnosed high nk cells in uterus, ana, mthfr. I was on pred, clexane and progesterone from ovulation then increased on bfp. Apparently with immune issues they can appear or increase after successful pregnancies and your body fights off pregnancies thereafter, if you are interested there is a thread with a lot of us immunology women on bh called high nk cells. you can read through our histories and ask any questions to see if you think this fits you. Good luck xx
31-08-2013 08:09 #14
Thank you Starfish and timetoshine.
I typed up all of my history to discuss with our fs but he just seemed to be so fixated with the PCOS and my infertility - but I am wondering if some months if we had a fertilised egg that it was unable to implant anyway. I did ask for a lap to check everything out, but he thought it unnecessary until a couple of months later, but then I fell pregnant!
Is it Dr Matthais that you saw timetoshine? I've heard a lot about him on bh. I popped over to the nk chat a few times to have a read when trying to work out what is wrong - I might come and ask some questions today.
I am wondering if there is someone better in Newcastle that I could see - or Sydney could be a possibility. Phone consults sound fantastic!
I had testing done after our second mc - that checked for clotting disorders and found the FVL - would they have checked for antibodies and NK cells? I think I've read that there has to be a biopsy?
I talked to my gp about the possibility of scarring starfish after talking to you as I was quite concerned about it and I had an u/s to specifically check for it or endo - but then from what you've said I know thatu/s don't always pick up scarring. Our 3rd child's placenta was retained and also manually removed which could have caused damage.
I saw the fetal medicine ob just strolling around the halls yesterday and just wanted to get him aside with a big white board and nut it out, I don't know why I didn't entertain the thought more.
More than anything I want to nut this out because if I'm having problems there's a chance my daughter could in the future and I don't want her to have the same head-against-wall experience that I've had with conceiving and carrying babies.
Thank you for taking the time to care ladies - I will see if there is someone in town that deals with such things and will keep on asking questions.
31-08-2013 10:39 #15Senior Member
- Join Date
- Mar 2013
I'm from newie too little ted. I saw a local fs and she tested my blood for a lot of things (16 vials) but she only found the ana and she said there was nothing else she could do. She would only prescribe me progesterone and keep trying until we get one that sticks. I went to see dr Matthias on the recommendation of a lady on another forum, also read dr beers book "is your body baby friendly" and it made so much sense. Dr m have me a lap/hysteroscopy/biopsy and found the nk cells and some endo that I had no idea existed. He is fantastic and so caring and just wanted to get to the bottom of it. I have only actually had 2 appointments with him, the initial appointment and the results. Other than that it has just been over the phone with his receptionist or in hospital. Hope to see you in the nk cells thread xxx
01-09-2013 11:33 #16
Timetoshine - how long of a wait was it to get a consult and lap with Dr M? I'll pm you who we were with this time.
01-09-2013 12:33 #17
Just found this information on the Genea website which rules out blood to baby issues I think.
"For a long time, it was believed that thicker, "sticky" blood can cause first trimester miscarriages because it leads to blood clots in the developing placenta, preventing the embryo from getting the oxygen it needs. We now know that the first trimester placenta doesn't actually have any blood flowing through it- blood vessels are developing but they are plugged by placenta cells. In addition, our experience with embryos in IVF has taught us that oxygen is toxic to early embryos, so direct blood flow would be damaging."
But then this:
"It now appears that the antiphospholipid antibodies in acquired thrombophilias, or the proteins made by genes in inherited thrombophilias, prevent the placental cells from properly attaching to the mother's uterus. Without normal placenta development, the embryo cannot grow."
So...how do I get these placental cells to attach properly to the uterus???
Last edited by Little Ted; 01-09-2013 at 12:37.
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