Just looking for people with similar experience and what treatment plan they had to have a successful pregnancy. Have just had 3rd mc in a row after having successful pregnancies. Bubs are not implanting properly and there is a blood flow issue. I have hetero factor 5 leiden and pcos. Was on aspirin after o but it didn't seem to help.
Last two mcs were around 7-9 week mark.
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30-08-2013 17:59 #1
Recurrent mc and implantation/blood flow problems
30-08-2013 18:09 #2
Folate, Asprin and Clexane :-)
30-08-2013 18:13 #3
Oh, I also used progesterone pessaries, and estrogen. I will just look up the doses FYI :-)
30-08-2013 18:23 #4
Folate 5mg per day
Aspirin 100mg per day
Clexane 40mg injection per day
Progesterone pessaries, 200mg twice a day
Mircrolut 2mg, 2 tabs 3 times a day (6 total)
Prednisolone 10mg per day
All this to 17 weeks, and then stopped Pred, Hormones to 24 weeks, everything else to 48 hours before delivery.
I have Lupus Anti-Coag
30-08-2013 18:25 #5
Thank you ladies - I did enquire after progesterone and clexane support this time, but was told that I didn't need either. Will ask fs when I see him in a month. Doses will be great. How far did your pregnancies get before they stopped?
30-08-2013 18:45 #6
I had implantation failure with just Asprin/Clexane, which is what we started with.
After this regime, I have my first DD, 13 weeks old :-)
30-08-2013 18:45 #7
Implantation failure was IVF, the embryos were perfect, but they just wouldn't stick!!
Before then I had a history of years without getting pregnant, and one known MC at about 7 weeks.
30-08-2013 18:54 #8
Thank you Zabella and Citrus Rain - I'll write these things down and see what our fs is prepared to do - I don't want to do this again without it being taken seriously.
30-08-2013 20:30 #9
I'm sorry to hear you've had another loss I had 3 mcs all around the 6-8 week mark and also 3 chem pregnancies. I also am heterozygous for Factor V and was on clexane for the duration of my successful pregnancy (including 6 weeks post partum). I know of several other people with factor V (including my sister) who were also on clexane for their entire pregnancies so I would definitely be pushing for this.
Just curious how do you know you have a blood flow issue, and do you mean to your uterus? As this could indicate damage to the endometrium which would in turn impact on implantation failure.
Hoping you will get somewhere with your current FS, although I wouldn't hesitate to seek another opinion if you don't feel your concerns are being heard. I went through 3 FS before I was successful and found one who was willing to work proactively with all of my various issues!
30-08-2013 21:17 #10
It is mainly the sonographers that have told me what is going on - had early bfp, but then first scan at 6wk1d was dated as 5 wks and I knew there was something wrong but they wouldn't discuss it and just told me to come back in two weeks. 2nd sonographer said that bub had implantation issues, then a SCH formed but didn't directly influence bub, heart rate dropped, symptoms were strong at the start and then trailed off. Heart rate of second mc stopped before any bleeding was present. When I say blood flow - I mean that the placenta isn't good for implanting and then feeds the baby poorly til the 7-9weekish mark - probably too thick/clotting or baby coming away from placenta/uterine wall. Though I also had pins and needles in my feet earlier on in the pregnancy also that I thought was weird.
I also had bad ms with all of our successful pregnancies and only had symptoms at the start and then trailed off when they should have well and truly kicked in at the 6 wk mark.
FS put mc down to "poor egg quality" with the PCOS and wouldn't consider clexane and just started me on clomid. As soon as I got my bfp I called both them and my ob that I saw with the haematologist back in March and neither would see me again til 8 weeks, but the problem is from the start and bubs are passing before or by the 8 wk mark. I was on aspirin but it didn't help.
What annoys me is that I was prepared to go all out and be a walking pharmacy and pin cushion if it saved one of our bubs, but no one would even consider the possibility.
The registrar I saw today said that the FVL shouldn't have caused these issues this early on - this seems to be the general consensus of all the specialists I'm seeing at the moment.
Sorry - it's turned into a bit of a ramble. But I've found people on here so much more helpful than any specialist so far! Thanks Starfish
Last edited by Little Ted; 30-08-2013 at 21:22.
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