I always try and test on a weekend or dayoff...so I can have a day of pity away from work... as it is often just too hard to cope with sad results... and if I have done a home test then at least I am prepared for the blood test results... everyone is different though.
Results 291 to 300 of 770
27-10-2012 08:53 #291
27-10-2012 16:34 #292Senior Member
- Join Date
- Jan 2012
I have been secretly reading this thread and learning from you all. After 4 failed cycles and transfers and our complex issues, my age, fibroids, possible endometriosis and adenomyosis and my DH's severe MFI, IVF has not been an easy road for us. We have decided to try a natural FET with embryo glue. Not sure what that means but my FS is saying that they are getting better results. Apart from my vitamins wondering if I should take the cardiprin as I have antinuclear antibodies. My FS doesn't think prednisone has much evidence.
Wishing you all luck.
28-10-2012 08:53 #293
Sounds like a very hard IVF road. (((HUGS)))
I think the cardiprin might be useful. From what I have read it increases implantation. The other one worth asking about is Clexane- it can help too.
I have heard about the glue- but not researched it myself. How does it work?
Best of luck, hope this is your cycle.
The embryologist said that defrosting culls off less capable embryos- so at least you will know if it survives it's a strong one.
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28-10-2012 08:57 #294
kenta... this journey to a baby is certainly a hard one...and by the sounds of it you have had some huge mountains to climb.
the low dose aspirin can definately help... if you take it when you start injecting.. either syneral or lucrin or stims and continue it until you see an OB... prednsione would probably help a lot... pity your FS is not amendable... maybe use the lets throw in the kitchen sink cause the last 4 cycles have not worked and I need to try something .... even clexane... if you are feeling you are getting no where then maybe it is time to seek a second opinion... a lot of ladies have done this recently with a renewed feeling of hope....
Id also take B12 and high dose folate (megafol 5mg) as it can help with unknown immune issues like MTHFR.
fort.... thinking of you this morning...
28-10-2012 09:42 #295
I'm another lurker who has learned a lot from this thread over the past 8 months or so. I've decided to out myself and join in if you'll have me as you're such a supportive and chatty bunch. I also post on the 40+IVF board over at EB but it's a pretty quiet thread these days!
My husband and I have been TTC since August last year - (we met later in life) and are not having much luck at all - given my age and the fact that DH travels a lot (he's currently in Amsterdam while I'm ovulating!) we were told IVF would be our best hope.
I was with CFC in Melbourne and did 3 stim cycles with one Dr there - 1 antagonist - 5 embies I think only three made it to day 3 and none to freeze, one down reg - 5 embies, 3 to freeze. BFN only one embie made the thaw and also a BFN.
On my last FET with that Dr I was really disappointed. I'd explained to him that OPK's don't really work that well for me and I never get a true positive. My natural cycle was wacky after the stim cycle with extra long delayed ovulation - I got my first 'positive' OPK on day 37 - he did the transfer without a bloodtest to see if I had in fact ovulated (which I questioned at the time) I went on to have a 57 day cycle and if my luteal phase was the same, this meant he transferred the embryo 9 days before I actually ovulated. I questioned at the time if the cycle should be cancelled but he said it would be fine to go ahead as I'd had a postive OPK. I'm mad that I didn't push harder for a blood test to check for ovulation considering my cycle was so wacky (ended up being 57 days).
Since then I've had a couple of months off from IVF (and a holiday) and will be starting with a new FS within the same clinic next cycle which should start in about 12 days if my charting is correct. In my consult with the new FS she too questioned many of the decisions of the the previous FS which made me feel a lot better. I'll be doing another antagonist cycle (slightly higher dosage than my first attempt at this type of cycle) with half ICSI half natural fertilisation. She seems to have a lot better bedside manner and apparently calls her patients after a negative blood test (the other bloke I never heard a peep from) which will make for a nice change.
Micca you are such a wealth of knowledge to everyone who reads this thread - in regard to the low dose aspirin do you know what kind of dosage you're supposed to take? I might give it a go this time around.
Anyway sorry for the long post but I just wanted to say hello and I look forward to getting to know you all better.
28-10-2012 11:22 #296Senior Member
- Join Date
- Jan 2012
thank you all for welcoming me.
Fortitude - I tried embryo glue before with not much luck but can't hurt is what I understand. Have also asked about hatching before but they seem to think that because with use ICSI/PICSI that there is already a hole. I asked my FS about that or endometrial scratch and he suggested the glue again. Cardiprin he thought it might be useful but didn't recommend when to start. I did ask about clexane and steroid but he wasn't so keen as more for women with history of miscarriages. I guess without ever been pregnant I didn't fit that category. Hope you are doing well with your 2ww
micca - I tried cardiprin and prednisone 5mg daily last cycle after EPU and hcg post ET. We also did that cycle with another FS but are going back to our old FS as despite all our BFN feel he genuinely cares. The new FS we tried to try another clinic we were disappointed with our experience. However, given that I think they do know what they were doing. He just wasn't for us but will try another FS if this doesn't work next year for a last ditch "throw the sink in" cycle. For now with our only frozen we are going to do a natural cycle transfer, apparently with no drugs except I guess I can start cardiprin at some time. Maybe it will be better as I will have had a drug free cycle when we do this as this is a wasted month.
Emski - I too met my DH late in life and tried with no luck until we decided to investigate and found my DH had severe MFI so we had also been wasting time. IVF is so full of promise at the start but the stark reality hits after many failed cycles that it gets hard. I empathise with you as we have done 4 cycles and been on infertility journey for 2yrs now. In 4 cycles we only had one egg freezable and that's the one we are going to transfer and see if it will work this time. I think also after a stim cycle the cycle after it is always out of wack which is why I think some FS like you to wait a cycle. I also think it's important to be able to discuss things with your FS. The new FS we went to I actually found stressful as didn't like answering my questions.
28-10-2012 11:45 #297
emksi, kenta... its a hard road... and you are young... 40 is better than 42 and better than 44yrs...
for both of you it probably comes down to a numbers game...
I managed to have DD using 41.8yr old eggs so there is definately hope for you. I am a great advocate of throw the kitchen sink in .. and my FS takes this approach with a lot of success
Aspirin... 100mg day... start at CD1 or with lucrin or syneral... 2 effects can help implantation by reducing microemboli in the uterine capillaries and if you get pregnant it reduces the risk of pre-eclampsia, pregnancy induced hypertension.
prednisone.... can aid implantation by reducing failed implantation due to immune factors... this is a topic that more and more info is coming to light. It does not cross the placental barrier.
immune issues that may respond to prednisone
ANA antibodies (at higher levels )
natural killer cells
rheumatoid arthritis etc
inflammatory bowel disease - colitis, coeliac, etc
high folic acid (5mg)/B12 - aids in decreasing high homocystiene (PCOS and MTHFR gene which is linked to miscarrage and congential cancers... and implantation failure
vitamin D... low vitamin d levels linked to decreased implantation.... however there is some question as to high doses cycling can impair ovulation... there are also some studies which showed that women of asian origin benefited more with lower vit D levels than caucasian women whom needed higher levels.
thyroid... most important hormone linked to infertility... TSH should be at least <2 prior to starting.
LH-- luteinising hormone... linked to the quality of the eggs, it is a precurser of testosterone.. ... too much and the egg quality is poor --as in PCOS.. too little and egg quality is poor. low LH cycling can be helped with menopur or luveris
the ratio of FSH to LH tells a lot about fertility
If LH>FSH = PCOS
FSH/LH ratio >2 then diminished ovarian reserve
I hope this helps... just some random info for you all
28-10-2012 13:49 #298Senior Member
- Join Date
- Jan 2012
Thanks micca for sharing. I wonder what dose of prednisone to take and when to start it as I have antinuclear antibodies. I think ill start cardioprin on day 1 of period as you suggested.
28-10-2012 17:23 #299Senior Member
- Join Date
- Jun 2010
Hi Kenta, welcome to the IVF Over 40 thread, you will find it a very informative and supportive thread and all the ladies here are simply wonderful.
There seems to be some similarities between our medical backgrounds.
I have very mild endometriosis and adenomyosis. Both were discovered about 2 years ago during a Lap and Hyst when FS discovered a ‘shadow’ in/on my uterus. I also have elevated ANA: 2010 = 1:40, 2011 = 1:60 and 2012 = 1:640. So there was a pretty big jump from 2011 to 2012 compared to the previous year. FS referred me to a specialist, however, shec ould not find any underlying clinical disorder/s and due to this, did not recommend the use of any medication for my next cycle (FET), including the use of Clexane. Therefore, my FS, in his usual conservative approach, did not do anything different and in fact, recommended exactly the same protocol as my last 2 (failed) cycles. Hence I sought a second opinion with the head FS at the same clinic, but he is based in Perth and he is adamant that the antibody finding can be relevant to implantation.
So my new FS recommended the following to enhance the chance of implantation during my FET:
1. Cardiprin (100 mg per day) from Day 2
2. Prednisolone (2 x 10 mg per day) on first day of luteal phase – this dosage will be reduced when pregnant
3. Clexane (20 mg per day) injection on first day of luteal phase
I have tried assisted hatching on my last 3 cycles, however, my new FS recommended embryo glue due to the type of technology used at my clinic that makes the incision for assisted hatching…apparently it is not ?laser which makes it ‘inferior’ technology, something I did not really go into any depth with FS.
I can also back up what Micca was saying about Vit D. My new FS made particular mention about my Vit D levels not being the ‘culprit’of my failed implantation/s, as I have good Vit D levels. In my “Fertility and Assisted Conception” book/’bible’ it says that a “deficiency of vitamin D is common among people with inflammatory and auto-immune disorders ranging from rheumatoid arthritis to multiple sclerosis.This may be relevant for women who have experienced unsuccessful IVF cycles”. Elevated ANA is 'linked' to inflammatory and auto-immune disorders, so it is very worthwhile having your Vit D levels checked. Natural sources of Vit D are sunlight, eggs, oily fish and some foods are fortified with Vit D.
I hope this info helps, but the most important advice is seek a second or even a third opinion…it is the best thing that DP and I have done. I was so frustrated with the conservative approach from my old FS….even if this new FS protocol cycle does not work out for us, as least we can say we tried something new and different and not another 3rd time in a row same protocol with the same negative result and I have paid another $4000 for the pleasure of it!!!
Good luck .
Last edited by Sunny15; 28-10-2012 at 17:40.
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28-10-2012 17:31 #300Senior Member
- Join Date
- May 2012
Hi, can I join in? I've been stalking this thread for the past few weeks. I turned 40 about 3 weeks ago and DH and I are starting our first round of IVF in early Nov. I have my appt to pick up meds on Tuesday.
Much like Emski, I met my DH a bit late in life. We sought IVF advice early as I have fibroids but found out that it's actually MFI (only 2% normal forms, but count, motility etc are ok) that's likely to be the problem and we'll have to wait and see about how the fibroids impact if/when we get pregnant.
I had a fairly high AMH, which is good news...but I'm really scared of getting ohss. I guess I'll have to take it as it comes. At the moment, I'm cautiously optimistic about how it could go and trying to prepare myself for things potentially not going well. I know a BFP first time around is pretty unlikely.
Best of luck to you all in this difficult journey! I find these forums a huge help.
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