TMI alert in advance, sorry!
I am currently on CD12. I have had 75iu of Puregon days 3-5 and then 100iu Puregon from day 6-12. I had a scan on CD9 and only had follies rangeing in size from 7-12mm. Nurse said to have a re-scan tomorrow and to start Orgalutran yesterday, just in case. I had my Orgalutran shot at 4pm yesterday as she said to do it in the afternoon, but today I have just had a large amount of EWCM and I am worried that the Orgalutran might have been too late or not working. Is it normal to still get EWCM on IVF or should I be worried?
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14-05-2012 12:30 #1
IVF Girls, could you please give me some advice
14-05-2012 12:34 #2
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14-05-2012 12:37 #3
14-05-2012 12:47 #4
So in a natural cycle where you're growing 1 egg, it doesn't make enough oestrogen for you to notice EWCM until it's grown big enough to be about ready to ovulate. Which is why in a natural cycle the timing of EWCM correlates with an egg being ready and with ovulation.
But in an IVF cycle where you're trying to grow lots of follies (and eggs), if you've managed to recruit a heap of follies then each one only needs to make a little bit of oestrogen for the total amount to add up to enough to produce EWCM.
It is LH (luteinising hormone) that triggers ovulation. Orgalutran (antagonist drug) stops the LH surge so you won't ovulate, but oestrogen will continue to rise as those follies mature. At the last blood test before you go for egg collection approximately 1000 oestrogens equates to 1 mature egg. (The exact amount of oestrogen per egg varies from person to person, so that number is just a guide for your first cycle.)
Orgalutran is an "gonadotropin-releasing hormone antagonist".
Antagonist means it gets in the way and blocks something from working.
Orgalutran blocks gonadotropin-releasing hormone (GnRH).
Gonadotropin roughly means gonad growth. So gonadotropins are responsible for things happening to your gonads.
Gonadotropin-releasing hormone is responsible for letting LH (and other fertility hormones) out of the pituitary. Therefore it causes the LH surge needed for ovulation.
So if you block GnRH then no LH surge so no ovulation.
While we're on definitions (which for me helps the complicated names make sense):
Oestrogen generates oestrous.
Oestrous originally means "gadfly", and from there the meaning wandered to frenzy then to sexual desire and/or being "in heat".
Last edited by felicita; 14-05-2012 at 12:52.
17-05-2012 20:31 #5
I did the same freak out on my first cycle! My FN said the increased CM was a good sign and what they wanted. Try not to stress. Def ring and ask any qs to your FN or FS nothing is silly x
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