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  1. #1
    EternalOptimist's Avatar
    EternalOptimist is offline Never say you have failed until you have reached your last attempt; never say you have reached your last attempt until you have succeeded.
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    Default Miscarriage

    Hi Dr Sterling,

    A little bit of background, we have been TTC to 2 years, after doing all of the different tests we have been advised that my Husband carries the Cystic Fibrosis gene and suffers Azoospermia. He produces sperm in his testes but thee is no tube to transport it to the outside so we need to use testicular aspiration and ICSI to be able to conceive a child. My Husband had all types of Karotype testing done in the beginning and I believe this is the only issue with his infertility.

    In August 2010 we underwent our first cycle of IVF and were fortunate enough to get our BFP the first time (transferred 1X 5 Day blast), unfortunately this resulted in a missed miscarriage at 8 weeks. I was really surprised by this as i was told my levels were all really high and i had EXTREME morning sickness wich my Dr advised was a really good thing and indicated a healthy pregnancy. I went for a scan at 7 weeks only to be told the heart beat was 60BPM and it was measuring 5w3d, very small for where it should be, then second scan the following week revealed no heart beat at all. The FS has sent of a sample of the placenta to determine the cause of this, and the results aren’t due for another week. My FS scheduled me for a D&C the following day so it would be over with quickly and we could try a FET on my next cycle.

    So my question is:

    - We still have 2 frozen blasts, what are the chances of these two resulting in the same as our first blast?

    - Would my husbands condition been the cause for this miscarriage?

    - I only had one blood test to find out I was pregnant, and no follow ups until the 7 week scan. Should my clinic have done a few more in those three weeks to check my levels?

    - And lastly, since my D&C my legs have been aching all the time. I am a very fit person and it feels like I have run a marathon every morning when I get up – is this anything to do with the procedure?

    Many Thanks for your help

  2. #2
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    Wow what a question.
    Your husband has CBAVD and is commonly associated with CF carrier status in white caucasians (1 in 26). This is not the reason you miscarried and hopefully your chromosome analysis will confirm this. The chances of your frozen embryos resulting in the same outcome is no greater than the first time. Blood tests wont necessarily tell the full story and ultrasound is necessary after 6 weeks to confirm all is well. Symptoms do not mean all is well. Leg problems probably not anything but you should see your doctor to exclude important causes. Good Luck your specialist is all over it GS

  3. #3
    EternalOptimist's Avatar
    EternalOptimist is offline Never say you have failed until you have reached your last attempt; never say you have reached your last attempt until you have succeeded.
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    Thanks for your reply, We have now had all our Chromosome tests and Blood tests come back and these all have come back as normal so we are still no further ahead with finding an answer. The only thing I don’t seem to have been tested for out of all the tests possible is for NK cells. Do you think it would be worth while pressing my FS to test for this?

    Also I have read in Dr Alan Beer’s book on immunology that 60% of males with Obstructive Azoospermia have Sperm Antibodies. Would the clinic normally test for this at the time of the TESE or do I need to ask for this to be done on the remaining frozen sperm. There are very limited amounts of DH sperm left so not sure if this is an option?

    Thanks again

  4. #4
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    There would seem to belittle indication for either testing or treating NK cells. The tesa and subsequent ICSI make antibodies irrelevant. GS


 

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