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  1. #1
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    Question Two transfers in a row - Low HCG levels has anyone else had this?

    Hi all,

    I had my blood test this morning for the FET we did on the 18th December. (The blood test was a day early as MIVF is closed tomorrow.)

    Unfortunately not good news. My HCG levels came back at 7 which is not good for 15 DPO.

    I feel so devastated as the last frozen embryo transfer we did resulted in a low level of 14 at 16DPO. The levels rose over the next weeks but not fast enough or high enough and then the pregnancy ended just under 7 weeks.

    Has anybody else had this happen to them as well - that is had low HCG levels twice?

    I am in shock as I just can't believe this is happening to me again. I feel so devastated.

    I took the first time this happened as bad luck but a good sign as at least my body had got pregnant, so maybe it was learning how so that the next time I got pregnant I would have a viable pregnancy!

    Now that this has happened for a second time though I feel really scared and worried that I may never be able to have a baby as maybe this is saying there is something really wrong with my body or with our embryos.

    I feel so confused as I reacted well in my first stim cycle (got lots of eggs and had a good number of embryos frozen) and couldn't go ahead with that transfer as they were cautious about OHSS.

    In my scans leading up to the 3 FETs that I've had my FS always says my lining looks good and that my follicles are growing well so I just don't get why this has now happened twice?

    Are there any tests I should be asking my FS to do? Can they do a biopsy on my lining or the embryo if it's still there to find out what went wrong?

    I've got to go for another blood test in a few more days to see what is happening with the levels but after last time I know not to have any hope as the level is too low to go on to be a viable pregnancy. It just feels like de ja vu going through this again.

    I'm waiting to hear back from my FS as she's on holidays so I guess it will be a little while before I can find out more about why my body, or our embryos, whichever it is, don't want to go on.

    If anyone else has had a similar experience or can give me any thoughts I would be really grateful as I just feel really lost and scared about what this happening to me twice means.

    Sorry to sound so down.

    BB.

  2. #2
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    oh hugs to you !!!


    wishing4kids.

  3. #3
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    Thanks W4K,

    I just heard from my FS (she is so lovely - she will always call me back) and I feel a lot better as she said it is actually quite common to have multiple chemical pregnancies and she thinks we are just getting so much closer to the viable pregnancy so that has made me feel a lot better.

    She doesn't think that we should do any tests at the moment, but just keep hanging in there and if we still haven't had luck in a few months then she'd look at more testing.

    I am trying to take hope from her words and hold onto them instead of that fear and anxiety that unfortunately kicks in when something goes wrong.

    I saw that you have your BT on the 6th Jan and I am keeping my fingers crossed for you and I hope you have a lovely NYE and that the start of 2010 brings great news for you!

    BB.

  4. #4
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    Hi Buttonbub

    I am not sure why this has happened to you and can only hope that 2010 brings you more success.

    I had 2 x 5 day blasties transferred and my BT on 18/12 was + with HCG level of 40. I was bleeding and advised my FS, so he sent me for another BT on 23/12 which was still +, HCG went down to 24. My FS clinic is closed until the 4/01, and I was freaking out, so went to a GP and did another BT on 29/12 and it was still + with HCG of 150. Last blood test was 28 DPO. So HCG of 150 is soooo low.

    So I have no idea what the result will be next week when I have my scan with the clinic. I don't know if I am feeling any preg symptoms because the pessaries and oestrogen that I am taking.

    It is so hard knowing that I am pregnant, but how long for???? I am trying to stay as positive and calm as I can and next wednesday can't come quick enough.

    Have a great New Year and for you next year.

    Sharni

  5. #5
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    Hi buttonbub - Yes, I've had this happen too. I ended up having 2 chemical pregnacies in a row in Dec 08 & Feb 09. Mainly due to my age I spoke to my FS about further testing which he agreed to, all my embryos that had been transferred were good quality. No fragmentation and all slightly ahead of where they should have been. I didn't want to continue transferring good embryos if there was something going on in my body that was stopping the embryos from staying implanted & growing I ended up having a multitude of BT's and a Natural killer cell biopsy.

    My NK cell biopsy came back abnormal, my level was 44% (normal is under 10%). I was put on prednisolone for my next cycle to conteract this. At the time of my next transfer I was told all my bloods were normal . I did go on to get pregnant from this cycle & after 1st scan was told I needed to go on aspirin and clexane with no explanation. When I went to first OB appt at 9 weeks they requested my previous BT results & we discovered there was some abnormal results. I have a MTHFR mutation (blood clotting) & elevated homocystine levels (these 2 things are linked) and the midwife explained to me that this is why I would have been put on the clexane & aspirin. Unfortunately when our OB did a scan at this appt our bub had passed away. I had a D&C 2 days later and we discovered from testing that bub had trisomy 15.

    We went back to our FC and a new FS (1st one had left) who sub specialises in blood clotting disorders. He also checked the same previous BT results and informed me I also had elevated coeliac levels (gluten intolerance). For my Oct FET my medications were Elevit, Mega B vitamins, mega folate (5mg instead of .5mg), aspirin & prednisolone. Unfortunately I got a BFN that cycle. I continued on all the medication for my Dec IVF/ICSI cycle and at my BT my HCG was 39. It is expected that this is another chemical pregnancy as I got AF before my BT and my progesterone levels were very low. I have another BT next week to check my levels.

    Please realise you are not alone in what you are going through. It is a hard tough road but it is possible to get a sticky pregnancy. There is a thread in the IVF section in regards to implantation failure & testing. If you want to see what people have been tested for, this is a good thread as there is alot on information on it.

    I wish you all the best for 2010

  6. #6
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    Hi ButtonBub

    It's very confronting and upsetting when this happens, you know your body is trying to get pregnant but something isn't quite right.
    I had a biochemical on my 2nd egg collection, level was 22 and I subsequently m/c a week later. My next attempt was a FET and was positive,the hcg level was fine but I had low prog which resulted in a m/c at 9 1/2 weeks. I have had numerous attempts since with 1 attempt having a hcg level of 8 and another at 3. I just knew something else was going on with my body to stop implantation happening, a gut feeling I suppose you would call it.
    After all this I pressured my FS into further testing, I hounded him about NK Cells (Natural Killer Cells) that I had read about on this forum and the internet and he was reluctant to test me for it, as he believes its contraversial and if you have them then they're meant to be there for various reasons. I totally disagreed with him. My argument was if I have them then what is the point in me doing this if I'm going to keep failing and failing when it can be treated???? He then agreed to do more testing (but not for NK's) and in the meantime put me on clexane (a blood thinning injection). That cycle didn't work however in the meantime I had a number of blood tests including one for ANA antibodies which is routinely done in preliminary tests but this time it came back positive. ANA's cause inflammation of the uterus & can lead to m/c and can interfer with implanation, it's an autoimmune response in the body where sometimes antibodies do not recognise a pregnancy developing and can destroy the embryo. I insisted to be put on prednisone, FS was reluctant but as I had read that it can be successful said that I would like the option of taking it, he gave in and put me on it (I think he got sick of me whinging). The next cycle didn't work. However, on my final cycle we totally changed my cycle protocol and I continued with the clexane and prednisone (although FS was still reluctant to do the prednisone!) I am now, finally, just over 9 weeks pregnant and so far all is looking good.
    I will also point out that I went to see a herbalist just before I found out about the ANA's and she picked up that I had an overactive immunity & I was given herbs to help my body settle down. Overactive immunities can fight off anything going on including pregnancies (ie, why I have antibodies).

    There are a number of blood disorders that can interfere with falling pregnant (as Pisces11 has mentioned), so if it was me in your shoes right now I would push for more testing so you don't have to go through a lengthy, disheartening time like I have before finding out that there actually IS something else going on to stop you getting pregnant. It's taken me 20 months to fall pregnant again since my m/c.
    I still can't believe that Drs don't do further testing until several failed cycles & in some cases several miscarriages have occured, why should anyone have to go through that before it's done?
    Just my 2 cents worth. I hope you are successful on your next cycle. Wishing you the best of luck.

  7. #7
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    Hi girls,

    Thank you so much for your replies and explaining everything so comprehensively.

    Sharni72 - I am so sorry to hear you are in limbo land and I am keeping everything crossed for you that your HCG levels have gone through the roof at your BT next week. The waiting is so hard isn't it.

    Pisces11 and Kismet - you have given me so much information - thank you. I am so sorry to hear that your journeys have been so challenging and I am hoping for both of you that the pregnancies who have now are the ones for you and are successful.

    I have heard before that as you've described Kismet, fertility specialists are really reluctant to do more testing until you've had at least a couple of miscarriages.

    Girls, why do you think this is? I don't understand what reasons there would be behind the reluctance?

    It just seems so strange that as you said Kismet why should we have to go through the heartache of more losses before tests will be done?

    BB.


 

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