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  1. #1
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    Default 3RD time unlucky, male infertility factor, how many failures is a lot?

    Hi All,

    Keen for any advice, we have had one fresh transfer, 2 thaw cycles which have all failed. I'm 28, and as far as we know no female infertility. I'm really regular and ovulate every month - i have very mild PCOS. We are having IVF/ICSI because of male infertility.

    DH and I have one frozen embie left. We're not keen to just blindly go into the last attempt without being equipped with more information and some insight into why it's not working..... if there are any possible answers?

    You ladies all know how it is and how awful the failed cycles are, is 3 a lot? I'm just so down and need to know what the next best steps are.... I appreciate so many couples have it far worse than us with in terms of the infertility problems they face but any advice would be appreciated.

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    Hi Shapoodle - I responded to your post on another post. I'm 28, we are doing IVF for MFI and when we started we were told our odds were really good. In fact our FS was hopping for two pregnancies from one cycle (fresh and FET's). Anyway we had one fresh transfer last year (BFN), then a frozen transfer (BFN) and recently our third transfer another FET (BFN). I was supposed to do a transfer this month but I decided to go to FS the for answers, and I'm having a biopsy in a few days. He thinks my odds are still good and thinks I should just go ahead next month do my last FET and hope that it's the one. He thinks its a numbers game, but of course I'm frustrated, I feel like I had all this expectation on me to work, seeing that we are MFI and I'm letting not just myself down but everyone else too. What I mean is I get your frustration at not have any answers. Have you had a lap done yet?

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    Hi Nikki,

    I sent you a PM, it sounds like we are in exactly the same boat!!

    Keen to stay in touch, we need answers.

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    I've also had three failures and after this, FS ran blood tests for failed implantation. If your fs doesn't offer this, ask. You have PCOS so as a start, get your insulin and blood sugar levels tested, if they haven't been done recently.
    As to whether 3 is a lot-personally, at this point, I'd be more concerned after 6 and not having a positive result or answers.
    Last edited by fiasm; 17-03-2009 at 09:33.

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    Have they thought about doing a Tunnel Assay on ur partners sperm??

    All this time i thought I was the one with issues with PCOS, Severe Endometriosis, One blocked Tube but hubby did a sperm count and everything was normal until we went to our FS at fertility first, who does these tunnel assays to test males DNA fragmentation and in that we found out that hubby's % was 34%...when it should be 20% and below.

    Now what this does is:

    Males sperm are created in the testes, and travels up the epidermis. With a DNA fragmentation test, they see whether the chromosomes are tightly attached or not. because what happens is when the sperm travels up the epidermis and then through to our egg...along the process it loses and falls apart into pieces teh chromosomes and hence it is not a full chromosomed sperm and although it will fertilise it but often causes miscarriage or just doesnt' implant because it is not able to survive.
    We only just found this out yesterday and what hubby will now have to do is get a testicular biopsy...the day i go for my egg retrieval, hubby will have his biopsy done and they will take his sperm directly out from teh testes which will be much more younger and healthier and then fertlise it.
    This method is often very successful and not a very high risk of miscarriage.

    So i think its something to consider. It costs a fair bit of money but now i think its all so worth it.
    I feel that we were so lucky for our FS to conduct this test.

    Dr Derek Lok from Sydney IVF wil do the sperm biopsy and specialises in male fertility.

    its somethign to think about and apparantly tunnel assay is only now being looked into more because it is often not picked up in normal male sperm checks.

    Hubby's been told to take Centrum A-Z, C o Q 12 (100units) Vitamin E & C (1000units)

    Please keep me updated and see if you can get this test done on ur partner...and hopefully you can see the light at the end of the tunnel.

    We're only starting our first cycle of IVF today infact and the Tunnel Assay was the first thing my FS did for us. Costs about $490.00 but might be all so worth it in the long run with the POSITIVE RESULTS.

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    3 is a lot because you have so much invested in each try, but I don't think it is a big number of attempts. Just because you haven't been successful yet doesn't mean you never will be.

    Each person can only take so much, it's up to you to decide when enough is enough.

    Personally, I'm glad we stuck with it for as long as we did, because we have two gorgeous kids now - but it was tough!

    I hope you can find the strength you need, whatever your decision is ...

    Good luck

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    Hi Bubbs thanks for your notes.

    We have MFI so we already have had to have a testicular biospsy to obtain the sperm so not sure this is the problem.

    Fiasm thanks for the message, as I say i'm just not sure if 3 is much so good to hear you thougts on that = agree that after 6 it would start to be a real concern.

    A BT sounds interesting, what did yours show and what ae they checking for?

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    Lucky2bMum you were so persistent, 18 and 19th cycle it worked is that right?

    I'm so glad you got two gorgeous kids at the end of it all, congratulations x

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    Shapoodle - 3 is not many (look at my signature) i never get to freeze eggs so its a full stim cycle for me every time (thank god i do antagonist cycles).......i am very stubborn, which i think helps me move on and to try again and again and again

    Lucky - you give me so much hope and i am a fan of yours......good on you for not giving up.

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    Quote Originally Posted by Shapoodle View Post
    Lucky2bMum you were so persistent, 18 and 19th cycle it worked is that right?

    I'm so glad you got two gorgeous kids at the end of it all, congratulations x
    Thanks! Yes, numbers 18 & 19 were lucky for us. We haven't entered a lotto ticket since ... we figure we've won lotto twice now. The oldest one has a HUGE IVF debt to work off though!

    amum21 - thank you! Sometimes all someone needs is a little encouragement or hope to get them through a cycle ... and you never know - it could be the lucky one for them.


 

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