The bathroom wouldn't worry me as I could change it down the track to suit my taste.
Has the real estate agent said anything about the quirky floorplan?
Reason I ask is because we had a house with a very unique floorplan that sat on the market for months. The REA advised that "non traditional" floorplans can turn buyers off.
In terms of what I look for when buying a house, I look at thing along the lines of - price, location, size of house (in terms of number of rooms esp bedrooms), layout, storage, block size, neighbourhood before I get down to what the house actually looks like and whether or not I can imagine myself living there.
ETA things like paint colour, state of the garden and obvious maintenance issues can affect how I feel about a house. I'm not a fan of bright feature walls and would prefer neutral colours. A nicely maintained garden and green grass can make a house feel much nicer. Obvious maintenance issues and signs of neglect can turn me off.