I unfollow anyone who posts too many inspirational memes. They're boring and annoying.
Honestly though? Most of the people I've unfollowed have been pregnant or constantly posting about their babies. After suffering the loss of my little boy, I felt like my entire newsfeed was full of ultrasound pictures and happy families. The ones who complained about pregnancy or young kids were the worst. I would feel sick and start hyperventilating every time I looked at them.
I didn't unfriend because I was hoping I wouldn't always feel like that.