Hi, I know this gets discussed from time to time.. At my old clinic I have some frozen embies which I'm contemplating growing out and using PGS. They use the aCGH method and biopsie earlier than Day5 which is against the grain but a study I read said that with the aCGH technique if you biopsy earlier it can show you a more realistic picture as the less cells an embie has the more it will reflect the egg and it is the egg that brings most of the genetic abnormalities(probably controversial). Apparently Later on embies have some abnormal and some normal (they do earlier on too but if you take 2/6 cells it's better chance getting a representative picture - but also some would argue more stress on the embie)... And these Cells can correct selves as the embie develops.
I looked up some old studies and the meta-data (which all used an older technique called Fish) said that using PGS gave worse results for ladies in our age group !! Worse pregnancy outcomes- remember it's using an old outdated technique. I couldn't find any large meta data studies on the newer technique ( aCGH or NGS).
There's only one clinic in Oz that I am aware of that uses the even newer and possibly better technique called Next Gen Sequencing (Genea). I now understand when ppl say they have the best lab - I actually think this is what they are referring to. We have done two cycles with them but both cycles we didn't chance not having anything to transfer on day 5 And had nothing to PGS or freeze. In hindsight it could have been worth waiting to see if embie hatched but with my odds may not have.
I'd love to hear your views on PGS testing and whether we should spend $3k on it or save it for another cycle! Also whether you've come across any data for the aCGH method with our age group.