@tuxcat that's great news that the follies are a similar size.
for the dynamic duo.
I found a full article (rather than extract) that talks about mosaicism. Makes me wonder about PGS. Here are some quotes. Link to the article is at the bottom of the page.
high rates of numerical chromosomal abnormalities were also found in embryos from young women suggesting that these abnormalities are not exclusively related to maternal age
These potentially viable embryos are discarded, thereby lowering the number of viable embryos in an IVF treatment. It seems logical to assume that this results in an overall decrease in live birth rates. It is clear, however, as previously suggested (Vanneste et al., 2009a), that one of the rationales behind cleavage stage PGS, i.e. that the biopsied cell is representative for the entire embryo, is incorrect.
Indirect evidence supports the idea that diploid–aneuploid mosaic embryos are viable.
You don't know that it hasn't given you a better outcome yet Luv. Ok, on the face of it regarding egg maturity/fertilisation rates, it may seem like a worse result but the proof of the pudding will be when you get to Day 5 and see how many can be biopsied/frozen.
Of course, I'm hoping they'll all be either good enough to biopsy or freeze, but even if the usual 50% drop off rate happens, having 3 to biopsy would be an excellent outcome I reckon!!
Very interesting Luv
Mosaicism can happen when you have CVS/Amnio done too. In regards to the PGS, they need to do more study (perhaps with the mice) where they transfer these embryo's and if a pregnancy occurs, what % of the fetus's would be affected by some kind of chromosomal abnormality???
Either that, or maybe whomever the embryo/s belong to should be given the option of keeping them on ice and transferring them knowing that there is a risk that they could have chromosomal abnormalities???
Unfortunately, PGS etc isn't an exact science, they just do the best they can with what they know. I'm sure more advances will be made in the years to come.
winsor The 'donors looking for recipients' thread doesn't appear in active topics (but the meet and greet intro does), if that's what you mean? I found the easiest thing to do was to get to know a few other recipients and not to try to post to everyone (unless you are very good at small talk!), too easy to lose track. I especially try to keep in touch with anyone that has similar sense of humour or whatever.
faithandhopellove cool, I'll check it out
@green lady I feel your pain, my drop off rate from day 1 to day 5 was 70-90% so anything less than a good haul of 8 or so used to have me despairing. Ack, its just difficult to see numbers culled so quickly. Fingers crossed the ones remaining have benefited from the different protocol.
Faithandhopelove - I have read similar studies which i think is the reason for the move more recently to blastocyst PGD/ PGS rather than going it at day 3 or cleavage stage. Doing the biopsy of cells from a blastocyst is supposed to give a more accurate result on the abnormality.
Ah, hope working on a weak mind perhaps.
Pregnant for the first-time?
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