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  1. #1311
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    Quote Originally Posted by Green lady View Post
    @calypso75 - sorry to here about the arrival of AF. I think you always need to let the dust settle on bad news before deciding what to do next. I often change my mind between the day of getting the bad news and a few days later. I had EPU yesterday 16 collected but already down to 6 as only 10 were mature (worst maturity rate so far maybe due to the lucrin trigger rather than HCG trigger) and only 6 fertilised.

    6 out of 10 with ICSI is pretty good Luv!! I'm sorry there weren't more mature one's among the haul Yep, it could've been the Lucrin trigger or just a sh!t Cycle for you??? Hard to know really.

    and prayers being sent for all 6 making it to Day 5!!!

    Are you feeling allright???

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  3. #1312
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    welcome back @skye76. I think we can all understand the slightly obsessive state we get in during ivf cycles. it's good to have a break. glad to hear things have calmed a bit for you

    enjoy your driving lesson @Bongley

    & day off @midnite01, lucky you

    so sorry to hear @calypso75 I was hoping for a better result for you this cycle.

    yes, stay around @Molros, it will be nice to have you hear. sorry to hear about the health issues with your relatives. congrats on your BFP! could it be twins?

    speaking of twins, I just saw this article - turns out the FSH is involved so it explains why there's often a higher chance during IVF

    Genes behind increased chance of having non-identical twins identified

    http://www.abc.net.au/news/2016-04-29/genes-behind-increased-chance-of-non-identical-twins-identified/7368422?section=science

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  5. #1313
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    good luck @Green lady. 6 is a great result! for you

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  7. #1314
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    Quote Originally Posted by BlondeinBrisvegas View Post
    6 out of 10 with ICSI is pretty good Luv!! I'm sorry there weren't more mature one's among the haul Yep, it could've been the Lucrin trigger or just a sh!t Cycle for you??? Hard to know really.

    and prayers being sent for all 6 making it to Day 5!!!

    Are you feeling allright???
    Lucrin trigger was my choice as I just wanted to change something in the hope it gave me a better outcome. Doing luveris and Gonal f was also my choice for the same reason. I think my eggs are just all crap and no protocol change is really going to fix that. Feeling ok just hoping to have something to biopsy on day 5 or 6.

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  9. #1315
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    Quote Originally Posted by tuxcat View Post
    Yeah its funny isn't it, I was only thinking about the first coupe of times that I was so blissfully unaware of things, I just thought it was going to work!!! how wrong Ive been so far

    Yes Im just hoping that all the good things Ive been doing help that golden egg work FFS

    I thought I could see follicles on the right but she had a really hard time actually seeing the ovary. Oh well it is what it is. chances better than natural so thats what I have to focus on

    Hows your EDA stuff going? I haven't had much time to get on there properly
    maybe they'll find some more on RHS next scan/at EPU. yes, hoping they're great quality.

    going slowly at EDA. I got excited when I received an email from someone but they were just saying hi which was nice. at least it confirmed the message function works. I pop in every day or so apart from when I was away, but don't feel that comfortable there yet. will see how it goes. could take a while I guess. I've never been that good at small talk. and for some reason my threads don't appear in 'recent activity' link even when they've had posts. so probably flying under the radar if anyone is watching anyway. I just want to be pg again & have the healthy bub. all the waiting & out of my hands parts is hard to manage. at least when it's OE you can set the timeframe so that's one part you can control even if the result is out of your hands

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  11. #1316
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    @calypso75 I hated going for post AF HCG tests too. Hugs sweetie. When the dust settles let us know what your next steps are. I think some ladies here will have some ideas on meds to keep AF away if you are going to cycle again. Someone mentioned Luteal Phase defect (? @tuxcat) I think that's what I had. I ended up getting a script for crinone from my GP and upped my own dose but there are better meds than that the ladies can advise you on. Ah, but I am getting ahead of myself. For now:

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  13. #1317
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    @tuxcat that's great news that the follies are a similar size.
    for the dynamic duo.

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  15. #1318
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    I found a full article (rather than extract) that talks about mosaicism. Makes me wonder about PGS. Here are some quotes. Link to the article is at the bottom of the page.

    high rates of numerical chromosomal abnormalities were also found in embryos from young women suggesting that these abnormalities are not exclusively related to maternal age

    These potentially viable embryos are discarded, thereby lowering the number of viable embryos in an IVF treatment. It seems logical to assume that this results in an overall decrease in live birth rates. It is clear, however, as previously suggested (Vanneste et al., 2009a), that one of the rationales behind cleavage stage PGS, i.e. that the biopsied cell is representative for the entire embryo, is incorrect.

    Indirect evidence supports the idea that diploid–aneuploid mosaic embryos are viable.

    http://humupd.oxfordjournals.org/content/17/5/620.long

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  17. #1319
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    Quote Originally Posted by Green lady View Post
    Lucrin trigger was my choice as I just wanted to change something in the hope it gave me a better outcome. Doing luveris and Gonal f was also my choice for the same reason. I think my eggs are just all crap and no protocol change is really going to fix that. Feeling ok just hoping to have something to biopsy on day 5 or 6.

    You don't know that it hasn't given you a better outcome yet Luv. Ok, on the face of it regarding egg maturity/fertilisation rates, it may seem like a worse result but the proof of the pudding will be when you get to Day 5 and see how many can be biopsied/frozen.

    Of course, I'm hoping they'll all be either good enough to biopsy or freeze, but even if the usual 50% drop off rate happens, having 3 to biopsy would be an excellent outcome I reckon!!

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  19. #1320
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    Quote Originally Posted by faithandhopellove View Post
    I found a full article (rather than extract) that talks about mosaicism. Makes me wonder about PGS. Here are some quotes. Link to the article is at the bottom of the page.

    high rates of numerical chromosomal abnormalities were also found in embryos from young women suggesting that these abnormalities are not exclusively related to maternal age

    These potentially viable embryos are discarded, thereby lowering the number of viable embryos in an IVF treatment. It seems logical to assume that this results in an overall decrease in live birth rates. It is clear, however, as previously suggested (Vanneste et al., 2009a), that one of the rationales behind cleavage stage PGS, i.e. that the biopsied cell is representative for the entire embryo, is incorrect.

    Indirect evidence supports the idea that diploid–aneuploid mosaic embryos are viable.

    http://humupd.oxfordjournals.org/content/17/5/620.long

    Very interesting Luv

    Mosaicism can happen when you have CVS/Amnio done too. In regards to the PGS, they need to do more study (perhaps with the mice) where they transfer these embryo's and if a pregnancy occurs, what % of the fetus's would be affected by some kind of chromosomal abnormality???

    Either that, or maybe whomever the embryo/s belong to should be given the option of keeping them on ice and transferring them knowing that there is a risk that they could have chromosomal abnormalities???

    Unfortunately, PGS etc isn't an exact science, they just do the best they can with what they know. I'm sure more advances will be made in the years to come.

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