Tx @Charlie74 I'll have a chat with my nurse on Monday & see what she says. I was going to get DH to do sperm DNA fragmentation test, as we're doing ICSI HA due to MFI (not cheap $600 oop) but I've read that there's no point doing this test if we're already doing ICSI HA another thing i will add to my list to ask my nurse on Monday
Maxwellsmum can I suggest you check with Wazza before upping fish oil? I wanted to increase a few things at one point and he advised against it. Fish oil thins the blood and he'll likely have you covered for that (aspirin and clexane), so it might be too much? I accidentally ended up on 2000 and it really delayed clotting in combo with other stuff. Big difference from 1000.
skye76. That is why we started doing PICSI/HA-ICSI (with improved day 5 results). We talked to Wazza about it as well and he said yes it can be sperm, but egg is still a factor.
@infinity888 heart is broken for you today. This is the hardest and most unfair journey and you wouldn't wish it upon your worst enemy. I hope you can find happiness in your life beyond this time xoxo
skye76 Have heard/read the same as what the other Girls have said.
The first couple of days it's the egg then at about the 4 cell stage, the paternal genomes kick in but Wazza is also right as the egg is still a factor as well. Anyhoo..Have found this study about Paternal Influence of Sperm DNA Integrity on Early Embryonic Development.
Will copy and paste a little bit of it for you to read now and post the link.
There is much debate in the literature as to whether early embryo development is influenced exclusively by the maternal factors (Braude et al., 1988) or whether there are also paternal controls at this early stage (Tesarik et al., 2004; Baltaci et al., 2006). It is well documented that the first two embryonic cell divisions are primarily controlled by the maternal genes (Braude et al., 1988) and paternal effects commence at the 4-cell stage. Further, the detrimental effects of sperm DNA damage are more prominent during the later stages of embryo development (Dar et al., 2013). The described paternal effects on pre- and post-implantation embryos include slower embryo cleavage, poor morphology, lower blastocyst formation and lower implantation rates (Parinaud et al., 1993; Janny and Menezo, 1994). However, major discrepancies exist within the published data regarding the developmental timing and the extent of paternal effects on embryo quality.
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