@pingc383 I was just reading this thread and came across your question. I have had one pregnancy (one of 5) which lasted the longest (11 weeks) and then the baby stopped growing. I had a D&C and the fetid was tested. They found that it has 2 chromosomal abnormalities so was not a viable pregnancy. The question I had was why did it last until 11 weeks when all my other miscarriages have been early (within 6 weeks). But that's just Nature's mystery. Maybe the Bub was strongly trying to stay in there, who knows. So to answer your question, yes such embies can attempt to implant, however mine was a natural conception at that time. I've had two IVF PGDed embies transferred - one implanted but miscarried at 5 weeks, the other didn't implant.
Upon reading your history, it looks like you have some underlying immune issues that are preventing the pregnancy of PGDed embryos. I had day 5 PGD fyi.
@nattie84 basically my FS at the time (Gavin Sacks) said that it could've been because of anything and that doctors are not Gods to know everything. I remember I cried at that consult (I don't break easily in front of people, I was a complete mess at that time) and he said you actually have mental issues which you need to sort out (j thought he was rude but that's just how he is - quite blunt but a very nice person at heart and very good with treating NK cells). He performed a hysteroscopy after that miscarriage and took a biopsy of cells to test NKC. Turned out that I have extremely low NKC. He also performed a scratch but the next FET didn't even implant. I then performed testing with Dr Braverman in NY which revealed quite a number of immune issues. I'm cycling right now (EPU on Thursday) and will be using Braverman's protocol to treat the issues he found. Hope this helps.
Oh and Gavin also said that a lack of implantation could be because embie didn't like the thawing process and became weak or the embie didn't like the uterine environment (for whatever reason) or that the embie was not placed appropriately at the right location during the transfer. So it could be a number of factors.
Unfortunately, mine aren't grown to day 5.. My FS only grows them to day 3 and they just don't implant.. So I was trying to figure out if it's my eggs or if it's an immune issue.. I will most definitely be growing them to day 5 when I find a new FS, but I'm very nervous because on day 3 they are between 6 and 8 cells, only they are less than 10-20% fragmented. If they are fragmented at day 3, they won't make it to day 5..
I'm so sorry to hear about your losses. It must be very hard to understand why a PGD normal embie didn't implant.. Did you do Dr M's protocol? Sounds like an immune issue, given you had a PGD normal embie?
Did you ever go and see Dr M or just Braverman? Can I ask your age hun?
Who are you cycling with atm? Who is your FS?
I'm so excited for your EPU on Thursday!! Is your trigger tomorrow?? Did you change your stim protocol or is it much the same?
@pingc383 you're welcome hun. I'd say if your embies are not surviving till day 5, then there could potentially be some issue with your embies?? However, Braverman is not pro PGD and says that it discounts normal embies as well. But I'm still going for PGD this cycle as well as I don't want to take any chances.
Yes Gavin can be like that, he lacks emotional intelligence and is very to the point, but knows his stuff about NKC etc. I stopped expecting him to be emotionally savvy and life was good after that
I'm 35 and I've never consulted Dr M. I never suspected immune issues until the last unsuccessful transfer which didn't implant. So far all the doctors told us that we have 'unexplained miscarriages' and if we tried enough times, one will stick. But we just didn't want to go through all that pain again and again (my miscarriages are usually long and very painful, I always end up in emergency). Then Gavin suggested immune testing with Braverman as he was partnering up with Braverman - we were the first patients to go for Braverman's testing via Gavin. Since then, we've moved to Melbourne and I stared my cycle with Monash (Dr Nick Lolatgis). The whole protocol is provided by Braverman, the FS here only writes the scripts.
Yes my trigger is tomorrow and I found out today that I have only 5 decent size follicles so today wasn't a good day for me. This is when I am on a higher dose of Gonal F as compared to last cycle. I'm hoping there will be some good quality eggs.
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