Long post, sorry. Hoping that someone in the know might have some useful input...
I'll start off by saying that I've always had bad egg quality, even though no one knows why. Here's a brief summary of my ICSI cycles while TTC #1. All of these cycles were using Gonal F:
1: 6 eggs, all mature, 1 fertilised, BFN (bad sperm)
2: 10 eggs, 6 mature, only 1 sperm found, 1 fertilised, BFN (again bad sperm)
3: 7 eggs, 5 mature, 2 fertilised, embryos slow, Day 5 morula transferred and Day 6 erratic blast frozen, BFN (donor sperm),
4: 8 eggs, 7 mature, 2 fertilised, embryos slow, Day 5 morula, other emby didn't make it, BFN (donor sperm -- new donor)
Then we threw everything we could at cycle 5, including 3 months of CoQ10, DHEA, acupuncture, etc. I stimmed with 600iu Gonal F, and I used Saizen (HGH) during stims as well.
5: 15 eggs, all mature, 10 fertilised, 4x Day 5 blasts, 1x Day 6 blast, BFP and live birth (donor sperm -- same as cycle #3)
We've just gone back for our first stim cycle for TTC #2, and it was awful. We are at a new clinic, in a new country. The FS wasn't allowed to offer me any more than 300iu Gonal F, so instead asked me if I'd like to try Menopur instead, as he could bump me up to 450iu on that. I agreed, as I'd heard Menopur can be good for bad eggs. Also, they weren't able to offer me Saizen, and from what I can tell clinics in UK don't prescribe it. I was apprehensive about not using it this time, but thought it was worth a shot anyway. I spent 3 months doing all the same things as pre-cycle 5 again, same supplements (and then some), acupuncture, everything.
Here's what happened...
I went to my baseline scan on CD 2 and already had two follicles that were nearly 10mm and nearly 8mm. But my e2 was less than 150, so I was cleared to start stimming the next day. I stimmed for 6 days and went to my CD 8 scan, where I only had four follies and two were already the right size to trigger (18-19mm). The other two were 13-14mm. The nurse went to speak to her superior to ask whether I should trigger that night or not, and got the nod. So I triggered on CD 8, had EPU on CD 10, and got 3 eggs.
The next morning the lab called to tell me that 2 of the eggs were mature and were ICSI'd, but neither of them survived the ICSI process. They couldn't give me reason for it, just said it was "really bad luck". To my knowledge, this has never happened with any of my eggs before. Terrible fertilisation, sure, and I was expecting to hear that none had fertilised. But to be told they didn't even survive having the sperm injected into them was a horrible shock.
So was it the Menopur? Was it the fact that those follicles grew too quickly? That my body was screwy to start with by having measurable follies on CD 2 (why would this be happening??), and I probably should have been cancelled before I even started stims? I'm all-too-familiar with having bad cycles, but this one takes the cake by about 500%.
I'm yet to even book my follow-up, I don't even want to set foot in that place again TBH. But I guess I will have to at some stage if only to hear what the FS has to say. Plus we will get a tiny fraction of the whopping huge cycle fee refunded for not making it to transfer, so I guess I'll need to arrange that too (because of course there's no way they will contact me of their own volition!). But in the meantime I need some reassurance that whatever caused this is fixable, that we do still have a chance at having a second child, that my eggs aren't 100% screwed at only 34...