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  1. #1
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    Default Low PAPP-A Level & Trisomy 18 High Risk

    Hi all,

    I'm currently 15 wks + 2 days.
    We had a check up with our OBGYN yesterday, who revealed our 12wk Nuchal Translucency results with us.

    Baby is high risk for Trisomy 18, with a 1:203 chance.
    My PAPP-A levels were also extremely low at 0.14 MoM.

    Our OBGYN explained the risks that could occur with low PAPP-A (IUGR, Pre-eclampsia, Stillbirth, Miscarriage, Premature birth etc.) He mentioned 'high risk pregnancy' and explained that we'll need close monitoring. I have 2 scans locked in for the next month. We googled the condition and it all sounds very scary.

    I'm just looking for some reassurance. I'm 23 and have had 9 x first trimester miscarriages. This is my first pregnancy to go into the second trimester. The baby's growth as of yesterday is normal for 15 weeks.

    Has anyone else received a low PAPP-A score and gone on to have a normal birth experience and healthy bubs? What are the chances of things going wrong with such a low level?? Thank you x

  2. #2
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    Yes I had low pappa A with ds2 and he was high risk of trisomy 13 18 and 21. My risk score was lower than yours. Ds is a happy cheeky and perfect boy 😀

  3. #3
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    Did they wait 3 weeks to tell you this? Trisomy 18 is really serious. You should have been offered an amnio. That will tell you with certainty whether or not that's what you're dealing with.

    If it's just the Papp a and they rule out other issues there are plenty of cases of people with your level having healthy kids, but you should be closely monitored.

    You've had a really rough ride, hon. You deserve an easy pregnancy xx

  4. #4
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    Yes i did. But my risk for trisomy 18 was 1:128.
    we had an amniocentesis at 16 weeks and got the all clear. I needed scans every 4 weeks to monitor growth and regular appts with doctors rather than the midwives. I also ended up with gestational diabetes, so was induced at 38+4. Ds2 was born a healthy 7lb 6oz. He is nearly 4 months now and doing very well.

    Amniocentesis is scary but I'm so glad we did it. The amount of stress, fear, and crying i went through during the 3 week wait to have it after the initial risk results, enduring that and not knowing if my baby would survive was not something i could do.

    If you decide to do an amniocentesis find a reputable place. We went through queensland ultrasound for women in brisbane. Dr jackie chua is absolutey amazing, i didn't feel a thing.

    Good luck i hope all goes well for you.

  5. #5
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    Peony92 - have you considered a harmony blood test? - I had one after reasonable 12 week numbers which a doctor then questioned. I needed to know so thAt I could settle into my pregnancy. I have a beautiful healthy 20 month old!

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    My sister received very low results and was basically told to go home and make a choice.
    Turns out there was a clerical error and they entered the figures incorrectly. I Would be asking them to double check before proceeding with anything.
    My first thought would be amnio, but as someone who has also had too many miscarriages, I can understand that you might be hesitant of the risk involved.
    Good luck. I hope everything turns out perfectly for you.


 

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