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  1. #231
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    [QUOTE

    oh yes, it is age related (via telegraph article). dammit. now I'm wondering how many good, slower ones are discarded for frosties for being too slow when they might have been ok? (best not to think this way)]
    @winsor - yes this is what I think about

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  3. #232
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    yeah it's hard to say. from the different studies it seems there's lots of factors. we don't really know which is a higher weight of them all comparitively, if there is one. appearance rating must be the most effective means without testing since that's what's used now, and many are not suitable for testing or don't make it so don't need to be tested. it is good to see new developments in the science. I hope there'll one day be more known. it's still a relatively young field, so new discoveries are yet to be made

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  5. #233
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    Quote Originally Posted by Green lady View Post
    [QUOTE

    oh yes, it is age related (via telegraph article). dammit. now I'm wondering how many good, slower ones are discarded for frosties for being too slow when they might have been ok? (best not to think this way)]
    @winsor - yes this is what I think about
    Yeah me too. I had so many blastocysts not make it to freeze, almost every stim cycle I would have (I was always really consistent) 1 to transfer and 1 blast would go in the bin. Yet my slow very early 5 day blastocyst gave me a BFP.

    It always niggles me
    1: Would that blastocyst have been good enough to freeze at day 6?
    2: Were any binned that would have made it?

    My clinic told me that they have to be expanded by day 6 to freeze.

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  7. #234
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    I had a few slower ones but they always seemed to stop by day 5-6 as they told me they couldn't freeze. sometimes I thought, pop the trailer in and freeze the leading one and see if there's a difference. but I guess they can only go on current tech known at the time for best guess.
    the glucose article was watching them use the glucose in the lab solution. which was outside of me anyway. I'll see if I can attach it temporarily once on the computer.

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  9. #235
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    Gardner, David K., Petra L Wale, Rebecca Collins, and Michelle Lane. 2011. "Glucose Consumption of Single Post-Compaction Human Embryos is Predictive of Embryo Sex and Live Birth Outcome." Human Reproduction. 26 (8):1981–1986.

    background: The aim of this study was to determine the relationship between nutrient utilization by the human embryo and its subsequent
    viability after transfer.

    conclusions: The rapid screening of glucose metabolism by the human embryo on Day 4 and 5 may prove to be a useful metric in the
    development of algorithms for the selection of embryos for transfer in human IVF. Also, the observed sex-related metabolic difference provides
    preliminary data to support the hypothesis that male and female human embryos differ in their physiology due to the presence of two
    active X chromosomes and an altered proteome for a finite time during the preimplantation period.

    & this one, which was referred to in another article (though it's on animal tests as well so not sure if it's the same/relevant):

    Leese, Henry J. 2002. "Quiet Please, Do Not Disturb: A Hypothesis of Embryo Metabolism and Viability." BioEssays. 24:845–849.

    Summary
    This review uses nutritional markers of normal and
    impaired development to address the question; what
    makes a viable mammalian preimplantation embryo?
    Resolution of this question is important to ensure the
    long-term safety of embryo-based biotechnologies in
    man and domestic animals, the optimisation of embryo
    production and culture conditions and the development
    of methods to select viable embryos for replacement.
    After considering the nutrition of embryos and somatic
    cells, and the phenomenon of caloric restriction, it is
    concluded that preimplantation embryo survival is best
    served by a relatively low level of metabolism; a situation
    achieved by reducing the concentrations of nutrients in
    culture media and encouraging the use endogenous
    resources.
    Last edited by winsor; 20-12-2015 at 23:05.

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  11. #236
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    POAS report DPO10 (the afternoon edition):-

    Well despite me saying that the FRERs are consistent they are fluctuating slightly, presumably on concentration of wee. So now it is slightly darker but I held onto my wee for like 6 hours and it was very orange, sorry TMI


    Hope everyone is staying cool.

    Thanks for listening to my craziness.

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  13. #237
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    I hope this is the turning point. (I had some differences in darkness during a day too on last cycle - light then dark later in the day)

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  15. #238
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    of course, all of my stragglers had a very high chance of chromosome issues due to my age, so that's going to be why they stopped before any other factor even made it into play

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  17. #239
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    Default IVF over 40#23

    I'm sorry everyone I haven't kept up. I have had a quick scan every so often, just enough to say I'm so sorry @Summer and @Gagingi 😔 it's very unfair. And @Tahli, I can't believe you didn't get your BFP this time. I know the waiting would kill me, but you are doing the right thing with further investigation before using any more embies. I really, really hope you find the answer as there MUST be something else going on. @Bongley, my fingers are crossed for you that this is the one. Your TWW seems to be dragging more than any others I can recall !
    frickin auto correct
    Last edited by JulieMalooley; 20-12-2015 at 12:11.

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  19. #240
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    I've always wondered about my excess embryo's too on my first 2 Cycles. Just because they weren't good enough to freeze didn't mean that at least a few of them weren't chromosomally normal.

    It used to really upset me as it seemed like such a waste not only of the embryo's but of chances to get a BFFP quicker.

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