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  1. #221
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    @Chiefsgirl holy heck that looks painful, blimey the things we go through @Tahli POAS was pretty much the same as this morning, too close to call it. The FRER are very consistent. My internet cheapies are all over the shop (light then dark then non existent then dark again), presumably depending on how diluted my wee is.No symptoms.

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  3. #222
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    @Bongley Fingers crossed for the morning Hun!! At least the FRER are being consistent for you.

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  5. #223
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    Speaking of mitochondrial dna...just read this article of a new test that's been developed in regards to that....

    http://www.theguardian.com/science/2...-success-rates

    http://www.telegraph.co.uk/news/heal...n-by-75pc.html

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  7. #224
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    Quote Originally Posted by BlondeinBrisvegas View Post
    Speaking of mitochondrial dna...just read this article of a new test that's been developed in regards to that....

    http://www.theguardian.com/science/2...-success-rates

    http://www.telegraph.co.uk/news/heal...n-by-75pc.html

    thanks BiB, this is interesting. I wonder if this para in the guardian article could explain/match what we often see with the textbook sprinters that end up stopping early, and why often the slower ones make it - perhaps they have the normal amount of mitochondrial dna (from the mum) and the sprinters have the excess. I wonder if this is age related, eg if the older eggs have a higher amount of mDNA than younger eggs?

    "Scientists are not sure why some embryos experience a sudden rise in mitochondrial DNA, or how this affects their ability to implant. One possibility is that defective embryos make more mitochondria to give them enough energy to survive, but ultimately fail and stop growing."

    oh yes, it is age related (via telegraph article). dammit. now I'm wondering how many good, slower ones are discarded for frosties for being too slow when they might have been ok? (best not to think this way)

    "The research also revealed that the levels of mitochondrial DNA in embryos tend to increase as women age, implicating mitochondria with reproductive ageing."
    Last edited by winsor; 20-12-2015 at 01:10.

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  9. #225
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    it'd be interesting to find out from the different clinics how they decide on which embryo to choose. this 2011 study seems to suggest that morphology (the 'rating') is less important than the levels of glucose (& other nutrients) used by the embryos on certain days (and this is a predictor of gender also). I've never asked how they do this - just assumed it was on appearence of number of cells at the time (rating) (this was also on a small sample of tests, <=38yo so may differ for older women too?)

    http://humrep.oxfordjournals.org.dbg....full.pdf+html

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  11. #226
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    Quote Originally Posted by winsor View Post
    it'd be interesting to find out from the different clinics how they decide on which embryo to choose. this 2011 study seems to suggest that morphology (the 'rating') is less important than the levels of glucose (& other nutrients) used by the embryos on certain days (and this is a predictor of gender also). I've never asked how they do this - just assumed it was on appearence of number of cells at the time (rating) (this was also on a small sample of tests, <=38yo so may differ for older women too?)

    http://humrep.oxfordjournals.org.dbg....full.pdf+html

    I can't read the study Luv as you need an Id/p/word to access it

    Sounds interesting though Yes, I believe that PGS/PGD tested embryo's aside, the way they choose which embryo's to transfer or freeze (and test) is on appearance...cell numbers, size of blastomeres when assessing at the cleavage stage (are they similar in size with no mulitinucleation present??),degree of fragmentation etc or if at the blastocyst stage: blastocyst formation (which day??), blastocyst maturity, inner cell mass development, trophectoderm organization in addition to the blastocoel volume and expansion.

    I believe the presence of degenerative cells or dark grainy regions within the blastocyst are considered negative traits. Blastocysts having low TE cell number and degenerative cells in either TE or ICM are classed as “poor quality” and not considered suitable for transfer or freezing. They then Grade them accordingly for testing/transfer/freezing though as we all know, embryo grades don't tell us what's going on inside the embryo genetically.
    Last edited by BlondeinBrisvegas; 20-12-2015 at 06:28.

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  13. #227
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    POAS report DPO10:-

    Well, I did a test late last night and the line was definitely fainter than in the morning. Did a test this morning and the line is definitely fainter than the one last night. So still bottoming out. Really hope to see that line get stronger from now on. Will be going slightly cray cray today I suspect.

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    Quote Originally Posted by Bongley View Post
    POAS report DPO10:-

    Well, I did a test late last night and the line was definitely fainter than in the morning. Did a test this morning and the line is definitely fainter than the one last night. So still bottoming out. Really hope to see that line get stronger from now on. Will be going slightly cray cray today I suspect.
    Still early days yet Luv though I can imagine the anxiety you're feeling The line being so faint now will make it easier to see your BFFP when it arrives!!

    and prayers being sent for a squinter sometime in the next 48 hours!!!

    GO INCY GO!!!!!!

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  19. #230
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    Quote Originally Posted by BlondeinBrisvegas View Post
    I can't read the study Luv as you need an Id/p/word to access it

    Sounds interesting though Yes, I believe that PGS/PGD tested embryo's aside, the way they choose which embryo's to transfer or freeze (and test) is on appearance...cell numbers, size of blastomeres when assessing at the cleavage stage (are they similar in size with no mulitinucleation present??),degree of fragmentation etc or if at the blastocyst stage: blastocyst formation (which day??), blastocyst maturity, inner cell mass development, trophectoderm organization in addition to the blastocoel volume and expansion.

    I believe the presence of degenerative cells or dark grainy regions within the blastocyst are considered negative traits. Blastocysts having low TE cell number and degenerative cells in either TE or ICM are classed as “poor quality” and not considered suitable for transfer or freezing. They then Grade them accordingly for testing/transfer/freezing though as we all know, embryo grades don't tell us what's going on inside the embryo genetically.

    I think the long and the short of it is that they really don't know yet how to tell or how to improve anything. I think embryoscope will change how they grade embryos, but even now there's no tracking for how well embryoscope growth matches with takehome-baby rate!

    All IVF really does is increase the number of tickets in the lottery.

    I think this is really disappointing (and a reflection of how poorly women's health issues are researched in general) especially considering how easy it would be to collate huge databases on age/supplements/blood tests on IVF patients who are motivated and rarely lost to follow up!

    I don't understand why QFG, for example, doesn't PGS the arrested embryos or submit them for follicular fluid testing. I know it's expensive, but I just don't feel that they're that interested in actual scientific breakthroughs because money (it costs money and eventually less IVF cycles = less profit).

    $0.02

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