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  1. #211
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    Sorry for the messy kitchen and half renovated wall in the background!

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  3. #212
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    @Charlie74 A quickie. I've just received a reply from my nurse at CFC. Their intralipids are only 100mls with 500mls of sodium chloride run over 2 hours. I had no idea it was so little! I'll stick with LBs 200mls. Two Monash nurses have now said to me that just because other FSs will administer 500mls doesn't mean your getting an extra 300mls worth of benefit, if that makes sense. I have no idea...and I'm not sure the FSs do yet either tbh.
    @Bongley how was tonight's POAS?
    @Summer please feel free to tell me to sod off...but did you tell DH about your faint BFP this cycle?
    Thanks for your support re postponing my CT cycle girls. Big hugs.
    Last edited by Tahli; 19-12-2015 at 20:20.

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  5. #213
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    @Gagingi you asked me whether donor embryos was the cheaper option. All I can do is give you my rough figures. It cost me about $13.5k for the initial fresh cycle, all inclusive. I didn't do a CT holiday I just stayed in a local BnB for a week. The ICSI donor sperm is only $100.
    The frozen cycles cost around $3.5k depending on what month you fly over. Accom is very cheap, as is food. The transfer itself is only $650. It just depends what extras you add on such as meds, intralipids etc.
    If I have to create more embryos (do a completely fresh cycle) I personally wouldn't do a fresh transfer again. I'd have the embryos created, PGS done, frozen, then fly over. The success rates are around 60-65% fresh vs 50-55% frozen I believe.
    Has that helped?!
    Last edited by Tahli; 19-12-2015 at 20:37.

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  7. #214
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    Quote Originally Posted by Sue77 View Post
    Gagingi . So so sorry love... it's just so unfair .. I have also faced it with my normal pgd embies not working. . Then one begins to wonder what else can we try... but thankfully u are in very good hands with Wazza who is willing to try new things gs with u n is so accessible and already has a plan chalked our for u... is he adding something new in your next cycle ? And did he give u any reasons as to a normal embi nor implanting ? Because it can't be quality as they are tested...
    @Sue77 thank you for your thoughts (and all you other gals). I'm about to hit the wine and pizza with blue cheese. It's a shame I'm not hungry! Wazza was very matter a fact. Although the embie was chromosomally normal, he says that its still a gamble - just better odds, which haven't fallen in our favour. He said that as well as being chromosomally good, mitochondrial DNA also deteriorates with age and that can affect the embie quality/implanting (I think that is what CoQ10 is hopefully going to help with). He said we don't know where the line is with 42 and 43 in terms of the big drop in quality, but he will support us in stimming again, although still emphasises that donor eggs/embies would give us a much better chance. In terms of cycle, it will be synarel long down reg with GH, DHEA etc. He is adding in progynova early (i.e. starting whilst stimming) as apparently that can help with older eggs. We'll need to do intralipids again etc. So not much too different to last time. Fingers crossed we get some more normals and hopefully "shaking that macadamia tree" will get us somewhere.

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  9. #215
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    @Chiefsgirl holy heck that looks painful, blimey the things we go through @Tahli POAS was pretty much the same as this morning, too close to call it. The FRER are very consistent. My internet cheapies are all over the shop (light then dark then non existent then dark again), presumably depending on how diluted my wee is.No symptoms.

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  11. #216
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    @Bongley Fingers crossed for the morning Hun!! At least the FRER are being consistent for you.

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  13. #217
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    Speaking of mitochondrial dna...just read this article of a new test that's been developed in regards to that....

    http://www.theguardian.com/science/2...-success-rates

    http://www.telegraph.co.uk/news/heal...n-by-75pc.html

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  15. #218
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    Quote Originally Posted by BlondeinBrisvegas View Post
    Speaking of mitochondrial dna...just read this article of a new test that's been developed in regards to that....

    http://www.theguardian.com/science/2...-success-rates

    http://www.telegraph.co.uk/news/heal...n-by-75pc.html

    thanks BiB, this is interesting. I wonder if this para in the guardian article could explain/match what we often see with the textbook sprinters that end up stopping early, and why often the slower ones make it - perhaps they have the normal amount of mitochondrial dna (from the mum) and the sprinters have the excess. I wonder if this is age related, eg if the older eggs have a higher amount of mDNA than younger eggs?

    "Scientists are not sure why some embryos experience a sudden rise in mitochondrial DNA, or how this affects their ability to implant. One possibility is that defective embryos make more mitochondria to give them enough energy to survive, but ultimately fail and stop growing."

    oh yes, it is age related (via telegraph article). dammit. now I'm wondering how many good, slower ones are discarded for frosties for being too slow when they might have been ok? (best not to think this way)

    "The research also revealed that the levels of mitochondrial DNA in embryos tend to increase as women age, implicating mitochondria with reproductive ageing."
    Last edited by winsor; 20-12-2015 at 01:10.

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  17. #219
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    it'd be interesting to find out from the different clinics how they decide on which embryo to choose. this 2011 study seems to suggest that morphology (the 'rating') is less important than the levels of glucose (& other nutrients) used by the embryos on certain days (and this is a predictor of gender also). I've never asked how they do this - just assumed it was on appearence of number of cells at the time (rating) (this was also on a small sample of tests, <=38yo so may differ for older women too?)

    http://humrep.oxfordjournals.org.dbg....full.pdf+html

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  19. #220
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    Quote Originally Posted by winsor View Post
    it'd be interesting to find out from the different clinics how they decide on which embryo to choose. this 2011 study seems to suggest that morphology (the 'rating') is less important than the levels of glucose (& other nutrients) used by the embryos on certain days (and this is a predictor of gender also). I've never asked how they do this - just assumed it was on appearence of number of cells at the time (rating) (this was also on a small sample of tests, <=38yo so may differ for older women too?)

    http://humrep.oxfordjournals.org.dbg....full.pdf+html

    I can't read the study Luv as you need an Id/p/word to access it

    Sounds interesting though Yes, I believe that PGS/PGD tested embryo's aside, the way they choose which embryo's to transfer or freeze (and test) is on appearance...cell numbers, size of blastomeres when assessing at the cleavage stage (are they similar in size with no mulitinucleation present??),degree of fragmentation etc or if at the blastocyst stage: blastocyst formation (which day??), blastocyst maturity, inner cell mass development, trophectoderm organization in addition to the blastocoel volume and expansion.

    I believe the presence of degenerative cells or dark grainy regions within the blastocyst are considered negative traits. Blastocysts having low TE cell number and degenerative cells in either TE or ICM are classed as “poor quality” and not considered suitable for transfer or freezing. They then Grade them accordingly for testing/transfer/freezing though as we all know, embryo grades don't tell us what's going on inside the embryo genetically.
    Last edited by BlondeinBrisvegas; 20-12-2015 at 06:28.

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