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  1. #1
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    Default Immature Eggs and Empty Follicles Problems

    Hi Everyone,
    I am 37 and I have been undergoing IVF for 1.5 years. I am new to this forum or any forum for that matterJ. I have had 6 (5 full stimulated) cycles in that time with very disappointing results. It has taken a toll on me and my husband and we are desperate for some help/advise. Although I am getting a good amount of follicles at each cycle, and good sized ones, my main issues are that most and sometimes all my eggs are immature or they have not been able to retrieve eggs from the follicles at egg collection. All our tests thus far have been good with nothing pointing at any issues.
    I am wondering if this is something to do with the IVF protocols I have had and if this could be avoided with more thorough testing and more personalised treatment. I started reading about these types of issues and a lot of readings point to things like incorrect protocol, incorrect trigger dose or timing etc…
    I was wondering if anyone has had a similar experience and if they knows of any experts in this particular problem area that could help us.
    I live in Melbourne but I am willing to travel interstate if there is a chance this problem can be fixed.
    Thank you!!!

  2. #2
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    Hi there
    I am a frequent bubhub reader but haven't really been participating in the forums but felt that I had to reply to u. For a number of my cycles I had similar experience as you.......reasonable number of follicles but retrieving low number of eggs....empty follicle or immature eggs. On my tenth cycle, I did get a bfp with my now 2 year old. I was on so many medications on that cycle so can't say what helped. At that point I had been on Dhea for maybe 6 months. On this successful cycle I was on saigon(spelling), which is the growth hormone, clexane and prednisolone. Sorry m writing a rushed reply.....evenings r crazy with kids. Will come back to answer any questions u have ( didn't want to read and run)

  3. #3
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    Thank you so much for your reply and most of all for taking the time in between looking after your kids. I really appreciate it! It gives me some hope, it has been so draining. May I ask, were you at the same clinic for all 10 cycles and if I may ask the name of the clinic and I you recommend anyone in particular? I like my specialist but he has advised he has already tried changing the protocol a few times, but I can't help thinking that more can be done. I am not sure if we are allowed to post specifics on this forum in terms of clinic or specialist names, and I don't how to send private messages

  4. #4
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    Hi sunny37
    Yes there is hope. I know what it feels like to feel so desperate that u could try everything yet feel like u r being betrayed by your own body. In answer to your questions, I was with Ivfaust but changed the location of the clinic maybe on my fifth or sixth cycle to see a different specialist who was more experienced and believed in doing cycles with clexane/prednisolone. It was this 'new' doc that put me on Dhea which helped reduce the amount of puragon I was on. This helped to mature the eggs and avoid going to retrieval too quickly. I also took high doses of fish oil and coenzyme 10. With these things, the empty follicles 'syndrome' almost became non existent and my eggs would mature enough to fertilize. Unfortunately for me though, this didn't translate into a bfp but led me to concentrate on other issues.

    I had this huge gut feeling from the start of my cycle that I had implantation issues and although I had tested for natural killer cells, and didn't have this, I felt that I couldn't trust these results. I literally begged my fs to put me on Saigon, clexene and prednisolone. He was reluctant coz I didn't test positive for natural killer cells. However, for that cycle I wasn't gonna take no for an answer and it worked. So yes, changing to a new specialist did help esp someone who looks at difficult cases. Also it's so important to listen to your gut feeling.

    Sending lots of baby dust your way n pm me if u need further details. Good luck and hope your bfp is on its way!!!!


 

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