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  1. #1
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    Default break between FETs? Also intralipids help please!

    Hello,
    We've just done our second FET, with a BFN , both transfers were done with the intralipids and dex, etc, because I've got the NK cells. We've got one little blasto left in the freezer, and we'd prefer not to wait a cycle for our specialist appointment (he's away for a couple of weeks), because, well, I'm feeling the time factor closing in. We can go ahead without the specialist, and just do the same protocol if we like. Our specialist had said if the second FET failed, we might consider some other options, and when I asked what they might be (considering we'd already been tested for all the immuno guff that might impede implantation), he said that maybe we'd use the expensive intralipids rather than the common variety. So I have two questions for you amazing, supportive women out there: one, has anyone tried the expensive intralipids, and was it more effective (or does anyone know the stats on the difference in success rates)? and two, is there any benefit in waiting a cycle between FETs? It's so hard to get myself emotionally back on track after the results, but then waiting another 35 days till the next cycle is crazy-making in a different way.

    Any advice would be amazing, thanks!

  2. #2
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    I have never heard of an expensive intralipid alternative. What's the dose you had? Typical dose is 500ml. Can he be more specific? Did he mean IVIG? It is not an intralipid but a blood product which some immune ladies use. Perhaps post on the Nk cell thread. People on the Nk cell thread would be able to give u more ideas.

    All I heard is that the drugs do build up in your system.

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    avosmash  (08-07-2015)

  4. #3
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    Sorry, yes, it was the IVIG – I wasn't sure of the name of it. Do you mean that the drugs build up in your system, protecting you more, or that it's better to let them clear out before another cycle? Thanks!

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    A lot of women use ivig on the Nk cell thread. It is not intralipid. Some use neupogen as well, depends on the diagnosis.

    It builds up in the system meaning it helps more. Someone on the Nk cell did 5(?!) rounds before getting her bfp. It is not a magic solution. U just have to keep going.

    Are your embies PGD tested?

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    avosmash  (09-07-2015)

  7. #5
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    No, I don't think they are PGD tested (I'm guessing we'd know/have paid for it, if they were). It wasn't mentioned as an option. I've reposted the thread in the reproductive immunology section (NK cell thread weirdly didn't come up in search?) so hopefully I'll find out more. Thanks so much, bbhope!

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    Yup, that is the best thread to ask around. A lot of knowledgeable ladies. Yes, kinda waste of money without knowing if any embie is actually viable. I think one lady also did many rounds of immune treatment until she found out that none of her embies are actually viable.

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    avosmash  (09-07-2015)

  10. #7
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    avosmash  (09-07-2015)

  12. #8
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    Whoa, I had no idea. Why do they never tell us the full story? Do you know how much PGD testing costs, and what's involved? We'll be transferring in a couple of weeks, so is it too late for this embie?

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    Yes, it is too late for this embie. I don't recall how much. It is quite expensive as far as i know. It is as expensive as neupogen and ivig! You are looking at $2k per dose......Although i was told that genea is cheaper because they have their own lab for PGD.

    Normally, for people who don't produce enough eggs per cycle, they will do many stim to bank the embies and then do the PGD. PGD has to be done at day 3. I actually don't know why FS would suggest immune treatment first before PGD. I suspect it is because most people don't end up with many embies to transfer in the end. You also lose cells by doing PGD so not all embies are suitable for it.

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    Hi avosmash, have you tried to do an endo scratch between cycles? I you are going to wait a cycle before yourr next FET you could do the scratch on day 21 as it's supposed to aid implantation.


 

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