@Tahli So what you'll be wanting to see over the coming days is that line getting darker @ darker.
Hoping @ praying for the Lone Ranger Luv!!😊xo
Did you test again Tahli ? How did it go ?
I had my phone consult with Dr M regArding the blood tests he had made me do. And according to him my natural killer cells CD 57 are raised . He said the normal ones should be between5 to 6 percent , mine came out as 17.3 percent and it could definitely impact my implantation. Sohehas put me on a very aggressive immune protocol with 20mg prednisolone and 25 mg after ET , clexane starting ten days before ET and the intralipid infusion abt a week before ET and if I get a bfp then abt 2 more intralipid or IVIG. And he clearly said there is no point transferring embies without this and even if I fall pregnant naturally I have to do this as soon as my bfp is confirmed.
i told him that LB had checked me for nk cells and all in her initial tests she does and he said those tests are very general and the ones he did are very much in detail. I also asked him how come Implantation had happened to me twice a couple of years ago , he said nk cells can change anytime , some ladies have one kid and then they are unble to achieve a second pregnancy due to elevated nk cells.
i am so confused and stressed as to what to do now? Is 17.3 really too high that implantation can't happen? I have no clue and knowledge abt nk cells , but the fact that 4 blasts didn't implant with LB (2 were pgd tested normal) puts me in doubt and She also told referred me to a immunologist in Melbourne to check everything . But I wanted to go o someone recommended by somebody . So I went to Dr M as many girls on BH had used him. Now I am expecting my period around 25 th of this month and plan to do the fet with our last 2 left , and Dr M is going to send me scripts for everything and told me to give it to my doc . how does that work ? How do I give it to LB? Do I really need to do this aggressive protocol with my numbers? So many questions in my mind... Sorry ladies for the long post but don't know whom to ask and rely upon without you wonderful ladies ...
@Sue77 Oh Luv, it all sounds very overwhelming In one sense you have some answers now. In another, those answers have created stress and anxiety for you
The positive thing is something can be done to address this issue Everything he has told you about the more in depth testing for NK Cells and the cells changing in your body etc are all true from what I've read in my research.
Yes Luv, raised NK Cells can cause implantation not to happen as my understanding is that those cells see the embryo as an "invader" and attack it giving it no chance to implant. The drugs/intrallipid/IVIG therapy he's recommended for you will calm your immune system down so it won't attack your embryo.
I will post some links to Dr Sher's site that might help you to understand what's happening a bit better...Here is Part 1&2 of the blog for you to read:
As for LB..you tell her in light of the recent test results you and your DH decided it was best to seek further help/clarification from a doctor that specialises in the field immunology so you went and saw a RI Dr M (whom I'm sure she will know or know of) and after further testing this is what he's advised you to do so you want to incorporate that into your FET protocol. Tell her you hope she'll have no problem with that.
If she does, then I'd wait until I saw Dr L and do your FET with him as I'm confident he will do as Dr M has said. You can do the intrallipid/IVIG with Dr M and with Dr L is my understanding but you'd have to check on when they can both do it and also check if LB will do those parts of the protocol for you. If not, no point doing your FET with her IMO.
Here's a link to the Natural Killer Cells thread in the Reproductive Immunology subforum. A lot of those Girls are seeing either Dr M or Dr L or both for the same thing and doing protocols they've devised. Just copy and paste your post over there and the Girls will help you too. Many of them are on the Over 40's TTC IVF thread or the parenting thread now that they've gotten their BFP's after doing the same protocol you've been given.
If I was in your shoes, there's no way I would be transferring an embryo without doing the protocol Dr M has said to do. He's the best in the business Luv and if he says you need it, then you do. The Girls on the NK Cell thread will be able to advise you a lot better than I can as they have the same issues as you.
Everything will be ok...it's just a matter of taking one step at a time and organising things. We're all here to help you and support you tooxoxoxo
Last edited by BlondeinBrisvegas; 18-08-2015 at 14:21.
@Sue77 I'm glad it was a productive, if not confusing/full on, call with Dr M. I'm also with LB & she referred me to see most probably the same Melb immunologist as you. I never received a call or letter from them. I would be choosing to do what you did though & doing a phone consultation with Dr M. He sounds like he has a clear plan for you. Good luck hun!
I'm still getting positive POAS results due to the Pregnyl (3dp final 1500 booster). Results are slightly stronger at night than FMU. I'm in a wickedly bad head space. Not good. Bl**dy hormones.
@BlondeinBrisvegas My FN said it doesn't matter what strength of line shows up on the FRER tests. You can't read anything into it re hcg levels. I find this hard to believe as they're always very strong after the Pregnyl booster. Anyway, can the ClearBlue digital tests genuinely measure the amount of hcg in your system ie Pregnant, 1-2 wks since conception, 3 wks since conception etc. Ta for letting me pick your brain!!
@Tahli Thanks to @ScubaGal for posting that link to the test...so yes, there is some ambiguity with it. The only true way to know your level is to have a Beta HCG BT unfortunately.
Personally, I wouldn't waste my $ on a Clearblue digi, just go with the FRER. Your line *should* get darker when you have a true BFP. I most especially noticed over a 2 day period of comparing my first test the one I did 2 days later. The line was very obviously darker than the original test.
I think it also depends on how much HCG your body makes and how your metabolise it as to how dark the lines are. Some Ladies get a darker line in the arvo and some get it using FMU (which I have to say are the majority of women IMO).
Testing the Pregnyl out can fruck with your head allright Luv I know!!! Now that you've committed to it, you just gotta keep going until BT. BT is Fri isn't it?? Thurs/Thurs night should give you a bit more of an idea I'm hoping!!
Actually... @ScubaGal, feel free to add anything else as I know you know a fair bit about Pregnyl half-life and HCG levels etc..BTW Luv,hope all is well with you and your little man too!! xoxoxo
Thanks so much BlondeinBrisvegas for such a detailed reply .. Yes I have posted on the nk cell thread that u referred in the post ... And asked them as well if they know what is considered as high level in the CD 57cells ? Is 17.3 considered too high to have this aggressive protocol.. Hopefully one of the girls will answer to my query ..and some doubts can be cleared from my mind.
Thanks Tahli .. Did the immunologist in Melbourne u saw refered by LB did all the blood tests on u ? It's so strange he never got back to u .. Anyways wishing u all the best for a positive outcome in. This cycle.
Chrlie 74 I totally understand what's u are fee,I got love as u are in a similar position like me with newly discovered things and how to approach to our FS with all this and all these aggressive protocols on top of IVF. Good luck for your phone appt with Dr M and let me know how u went?
Dont know what I would have done without u girls with my IVF journey taking new twists and turns every few months.
Thanks so much for the link @ScubaGal, much appreciated esp when you're so busy with your little poppet. I've only ever used the ClearBlue digital with conception indicator 3 times & each time it was 100% accurate with it's prediction. I guess I was lucky! I had a pack of 2 here in the house so I just gave one a whirl & it said 1-2 wks since conception - thanks Pregnyl! My FMU is definitely weaker compared to my evening wee, even though I hold on all night!
It sooo feels like AF is going to arrive in the morning which would be bang on when she normally arrives but given the Orgalutran delaying 'ovulation' then it's due on Friday as my leutal phase is always 14 days. No idea if that's how it works after a stim cycle though? I was totally expecting no 2nd line tonight. @BlondeinBrisvegas I'll attach a pic for your perusal. Let's see how the next 2 nights play out if I make it that far.
Ta for your good wishes @Sue77. I didn't actually see the Melb immunologist as his office never rang to make an initial apt.
Last edited by Tahli; 18-08-2015 at 20:36.
Tonight's pic. Hopefully it doesn't load upside down again! xx
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