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  1. #891
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    Just been looking into it as u was told that prednisolone was a larger molecule and didn't cross the placenta but just checked out the molecular weights of dex and prednisolone and they are very similar. Found a study with states 88% of prednisolone in inactive by the time it gets to the placenta and from looking at the molecular structures I would suspect this is because prednisolone contains more OH or water soluble groups and hence is used up by our bodies much quicker. When I googled the half life if both dex and prednisolone, dex was over 50hrs and prednisolone about 15 so once again implying that our bodies metabolise prednisolone a lot quicker. Interested now and will try to find more info on it's inactivation before it gets to the placenta.
    Last edited by Nidhulaine; 03-08-2014 at 19:20.

  2. The Following 3 Users Say Thank You to Nidhulaine For This Useful Post:

    Fiona2  (04-08-2014),miissalina  (03-08-2014),Snowy12  (04-08-2014)

  3. #892
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    Quote Originally Posted by Hopefullyanotherbaby View Post
    Hi @Miisalina have you taken prednisone the last cycle? Is dex heaps stronger steroid then prednisone? Will you do the I realities again this cycle?
    I only took dex for 5 days and stopped day before transfer my clinic doesn't do steroids after transfer so I'm going to see dr m not sure if he'll want to do more tests or not before giving me a plan I'm already stimming so at transfer I may not be on anything except the dex for 5 days last cycle was the first time if done that and was the furthest I have gotten in a pregnancy but mind u it wasn't far at all so that was chemical number three I don't think I can emotionally handle the constant heart ache so my option is give it one more cycle as this time we are doing the long protocol hoping to get better embryos as I'm not getting any frozens we are collecting 19 eggs each time and if it still doesn't work at least I can say to myself I tried everything possible and then do the steroids and if something goes wrong ill no I had no other option or just jump straight onto the steroids still haven't made up my mind I'm thinking once I speak with dr m I'll have a better idea on what I'll do , also my FS isn't very familiar with high nk cells they just test for them so dr m should give me a proper run down on my issues , have u decided what you will do yet


    Me 26, DH 30
    TTC 4yrs
    Mild pco
    Mild endo
    Lap done 9/13
    4rounds of clomid with BFN
    5th cycle of clomid chemical pregnancy

    Started IVF jan 2014

    1st IVF Jan 2014: @WFC antagonist cycle started, cancelled day 9 due to over stimulation, 60+ follicles.

    2ND IVF March 2014: Next generation fertility ,Antagonist cycle, chemical pregnancy!!!!!

    *DIAGNOSED WITH HIGH UTERINE NK CELLS

    3rd: 1st FET May2014, started intralipids for the first time due to high NK cells in the uterus

  4. #893
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    Ok it appears that there's an enzyme that deactivates prednisolone and that's why so much less of it crosses placenta

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  6. #894
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    Thanks for the response ladies. Thanks for the easy to understand summary of science side @Nidhulaine! You're fantastic with your detailed responses. I'm assuming the increased half life etc of Dex is the reason it could be slightly risker, not that it's actually that stronger/different to pred.
    @Galea, hope you don't mind me asking, have you had success with Dex and not pred? Sorry I'm not sure of your hx.

    I struggle with all the meds-I don't even like taking panadol! Yes I'm mental! Guess I've got to do the benefits/risk weigh up-obviously pred hasn't been enough to do the trick. More to think about!!!
    @missalina, I was part way through a FET when I had my first consult with Dr M. He put me on prednisolone, clexane and doxycycline as a prophylactic measure while he waited for my test results to come back. At that stage I had no identified immune issues. He was pretty confident that I would have immune issues though given our age and number of failed cycles with no other issues. Good luck with your consult. Hope he's got the solution for you.

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  8. #895
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    Ahhhh thanks @Nidhulaine. Interesting.

  9. #896
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    @ladybug14 I havent had any success so far. Just failed implantations with CGH tested embryos. Perfect embryos, perfect lining and no explanation.

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    Makes it even more frustrating when everything is perfect and still nothing hey @Galea. Would be so much better if science was another 20 years advanced and we might have some more answers.

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    There is one thing....i read somewhere that if the embryo implants a day late, it increases the miscarriage by a lot. They did a study of 9 vs 10 vs after 10 days implantation. I dont remember the number but it is a scientific paper.

    I suspected my last implanted late, day 11 with implantation spotting. Thus, despite everything was perfect. It didnt work.

  12. #899
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    Quote Originally Posted by ladybug14 View Post
    Makes it even more frustrating when everything is perfect and still nothing hey @Galea. Would be so much better if science was another 20 years advanced and we might have some more answers.
    Super frustrating. We are researching the surrogate path.
    @bbhope thats interesting. I have never had a chemical or even a hint of pregnancy. No implantation at all for me even with all the steroids and clexane and vitamins etc.

  13. #900
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    Quote Originally Posted by ladybug14 View Post
    Thanks for the response ladies. Thanks for the easy to understand summary of science side @Nidhulaine! You're fantastic with your detailed responses. I'm assuming the increased half life etc of Dex is the reason it could be slightly risker, not that it's actually that stronger/different to pred.
    @Galea, hope you don't mind me asking, have you had success with Dex and not pred? Sorry I'm not sure of your hx.

    I struggle with all the meds-I don't even like taking panadol! Yes I'm mental! Guess I've got to do the benefits/risk weigh up-obviously pred hasn't been enough to do the trick. More to think about!!!
    @missalina, I was part way through a FET when I had my first consult with Dr M. He put me on prednisolone, clexane and doxycycline as a prophylactic measure while he waited for my test results to come back. At that stage I had no identified immune issues. He was pretty confident that I would have immune issues though given our age and number of failed cycles with no other issues. Good luck with your consult. Hope he's got the solution for you.
    ladybug the reason dex appears riskier is it is not deactivated by an enzyme whereas most of the prednisolone is. It is also my understanding from dr M that dex is stronger and from other things I have read if your on steroids long term for anything they will prefer prednisolone than dex.
    Dr M told me before that whether or not prednisolone will work depends on the results of your biopsy. I have maintained pregnancies on both but know there are some women than will need dex not prednisolone. Personally for me the most important aspect of immune meds were the infusions and timing.


 

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