Hi Leyshoja and Chris. Leyshoja - sorry don't know about vacuoles. Agree with Octoberbaby don't give up hope. Even with my last cycle the 4 embryos were all looking good giving me a lot of hope, and then at day 4 two just decided to arrest. So you cant really go buy their appearance. They can look good and not go anywhere and by the same token they can be fragmented and turn into a healthy baby. Welcome Chris and fingers crossed this is the one for you. Can I ask how many cycles you have done?