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  1. #611
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    Good work Missybear, SO glad you have taken control and found yourself a new FS. I think they gave up on you way too early as well. I'm thrilled you're not giving up either - hope you get your apt ASAP and we can follow your progress here again. Big hugs xx

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    missybear  (05-07-2014)

  3. #612
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    Hi Kelly70 and everyone

    I'm 43, single and did my first cycle in March - antagonist cycle on 450 Gonal F. Only 1 egg out of 4 follicles - right side only - no action at all left side! Made it to day 5 but PGD showed abnormalities.

    Kelly70 - I'm about to turn 44 so I just don't have enough time to change clinics and specialists and go through the whole process again, but if you do, find someone who will be more sensitive and open to your situation. Also check out Dr Warren De Ambrosis in Brisbane - he is apparently the guru for older women and treats out of state.

    I had to force my way into a follow up appointment (I was told 10 week wait even for an existing patient!) and nothing new was presented to me so I suggested a list of other things I wanted to try. Then at every stage, it wasn't followed through - wrong treatment plan with the nurses, wrong prescription sent - it was as though doing anything outside the 'burger franchise' system just didn't work.

    This time, the timing was definitely still a bit out but with 7 eggs (my FS said she would fall over if I got 8, so I hope at 7 she at least stumbled a bit), 5 fertilised. I feel very fortunate but I believe this wouldn't have happened if I didn't push change myself. According to the nurses, today is my next big hurdle. If 4 or more of my embryos have made it this far they will automatically biopsy 'No news is good news.' If there are less than 4, my FS is supposed to call me to find out what I want to do.

    They say it only takes one egg, but if you are older, and single, you don't get a lot of time to find it!

    PS - I'm doing PGD purely to rule out chromosomal abnormalities due to my age - it's crazy expensive, but with the clock ticking, I don't want to be transferring embryos that had no shot in the first place.

  4. #613
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    Ah welcome back Gem70, your posts keep dropping off, it's weird!

    I turn 44 later this year so I don't really have time to change either, but I am going to try and juggle both balls for now.

    Your fert rate is great, crossing everything for you!!

    With pgd I thought I read the embryos at this age might be too delicate to test or something.. Or that the strongest won't continue to develop anyway and that's test enough. I'm trying to imagine even getting to embryo stage to be honest!!

    If you wouldn't mind, would be great to hear what you did differently this time that brought about the better result (or pm me if you prefer).

  5. #614
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    Hi Kelly70

    Good news this morning - of my 5 fertilised, 3 are good to test. At my age it's still a long shot (only 1 in 10 will be normal), but I'm still tracking at the same attrition rate of someone much younger, so phew!

    RE: PGD, your embryos can still develop to day 3, and even implant with chromosomal abnormalities. My day 5 last time did. It's a totally personal decision but I just don't want to waste the time, plus I'm trying to avoid the additional emotional stress of miscarriage. The statistics I got where that 40% of embryos that come back as normal will result in a live birth - regardless of age.

    OK - the process was a doozy

    Syneral spray pre AF to down regulate
    Gonal F 450 for 6 days, then Menopur 450 for about 7 days - with antagonist (orgalutron - can't remember how to spell it!).

    It seems like the Menopur did the trick for me as it was then I started see results. Also adjusted trigger as I only had 1 egg last time.

    I spent over 100 hours researching - I tried to breakdown the areas that I had showed poor results in and look at all the possible reasons for this in over 40. Maybe I was just luck this time, but the results were a surprise even for my FS. Trying to stay positive but realistic and if I need to go again I would ask to lower my drugs slightly to take into account a longer stimming time as I seem to be more of a slow responder than poor responder.

    If only I could find a FS who would do all that thinking for me!!

    Do you know when you are going to try again?

    This is really outside the box, but the FS in the USA that came up with all these protocols for poor responders Dr Sher takes patients from overseas. Apparently you can do nearly everything via your own doctor right up until EPU and transfer when you need to go to Las Vegas - I think even a GP can manage the program for you here. Worth checking into as well.

    Kelly70 - I really thought I was a lost cause after my first cycle, particularly when I got no suggestions on how to do anything different and all the protocols seemed to be generic and for 30 year olds. If your instinct is you're not done yet, I'm proof it's worth chasing better ideas yourself.

    Happy to share more if you want - feel free to PM me.

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    missybear  (06-07-2014)

  7. #615
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    Quote Originally Posted by Jem70 View Post
    Hi Kelly70

    Good news this morning - of my 5 fertilised, 3 are good to test. At my age it's still a long shot (only 1 in 10 will be normal), but I'm still tracking at the same attrition rate of someone much younger, so phew!

    RE: PGD, your embryos can still develop to day 3, and even implant with chromosomal abnormalities. My day 5 last time did. It's a totally personal decision but I just don't want to waste the time, plus I'm trying to avoid the additional emotional stress of miscarriage. The statistics I got where that 40% of embryos that come back as normal will result in a live birth - regardless of age.

    OK - the process was a doozy

    Syneral spray pre AF to down regulate
    Gonal F 450 for 6 days, then Menopur 450 for about 7 days - with antagonist (orgalutron - can't remember how to spell it!).

    It seems like the Menopur did the trick for me as it was then I started see results. Also adjusted trigger as I only had 1 egg last time.

    I spent over 100 hours researching - I tried to breakdown the areas that I had showed poor results in and look at all the possible reasons for this in over 40. Maybe I was just luck this time, but the results were a surprise even for my FS. Trying to stay positive but realistic and if I need to go again I would ask to lower my drugs slightly to take into account a longer stimming time as I seem to be more of a slow responder than poor responder.

    If only I could find a FS who would do all that thinking for me!!

    Do you know when you are going to try again?

    This is really outside the box, but the FS in the USA that came up with all these protocols for poor responders Dr Sher takes patients from overseas. Apparently you can do nearly everything via your own doctor right up until EPU and transfer when you need to go to Las Vegas - I think even a GP can manage the program for you here. Worth checking into as well.

    Kelly70 - I really thought I was a lost cause after my first cycle, particularly when I got no suggestions on how to do anything different and all the protocols seemed to be generic and for 30 year olds. If your instinct is you're not done yet, I'm proof it's worth chasing better ideas yourself.

    Happy to share more if you want - feel free to PM me.
    Really useful information, thank you 😊

  8. #616
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    Woohoo, wouldn't mind a trip to Las Vegas!!

    Wow you've seriously done your homework Jem70 and are proof that pushing the FS (why aren't they across this stuff better considering women over 40 would have to make up a sizeable chunk of their client base? Is it easier and more lucrative to focus primarily on helping younger women?), putting in some hard work and thinking outside of the usual boxes can pay off. Your motivation is inspiring!

    I think you're lucky also to have such good egg reserves at this age still, it's really challenging when amh is low low low.

    The technique you used sounds a bit like a long down reg cycle? With the exception of the Menopur after the gonal f? I think my FS mentioned Menopur when I last saw her.

    My next cycle will depend on who I get in with first I think - I've emailed my current FS office for an apt and also waiting for MIVF to release my records so I can send to Lynn B and see if she'll take me.

  9. #617
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    @Kelly70 I hear you! It's bad enough to be called 'medically infertile' and of 'advanced maternal age'. If they are going to classify us so quickly, then our treatment should be as different as their attitude to us is.

    I'm definitely fortunate to have the egg reserves still but I think everyone over 40 comes with something they need to tackle - I had three:

    poor response to trigger
    slow response to treatment
    ovaries that like to take turns unless you push them harder and longer so less follicles because only one side wanted to respond instead of both

    My big research tip is work out what your weak spots are then stick to the actual research studies to find out what can be done about them. I got stuck in the forums for awhile at the beginning and the advice, while well meaning, wasn't always easy to interpret for yourself.

    My final protocol was a mashup of a few different things. You should have seen the pharmacist - thought it was a mistake because she'd never seen anything like it. Kind of reinforces the big mac approach to protocols of my clinic. I think I had over 30 injections so lucky i got over that phobia.

    As long as you ask yourself honestly and listen honestly to the answer, I say don't give up until your heart tells you it's time to give up.

  10. #618
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    Wow you really have done your research @Jem70! Maybe we should all head to Vagas.

    Looks like I am definitely out this time. AF arrived yesterday, to say I was gutted was an understatement I just feel so heart broken but if I am honest I am really not surprised. My mild OHSS that had me in incredible pain for 2 days after transfer had me wondering how anything could survive in there. Tomorrow is 11dp2dt so I will POAS to confirm then ring the clinic and go again, hopefully at least 1 of my frosties makes it through.

    I have done further research into Genea but that won't be an option as they only use known donor sperm.

  11. #619
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    Hi ladies, Gem welcome. Good to see more older ladies giving it a crack. I was going to do pgd on my last cycle but as I only got one egg I decided to not do it as it would not be worth the extra cost. Turns out I didn't need it after all. I was in the same boat as Kelly with low amh but my responses were up and down. The successful cycle was the one where I only got one egg.
    Kelly how are you doing ?

  12. #620
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    Ah LittleSparrow, I know that heartbroken feeling.. although tougher to get that bit further along I think. Massive hugs to you lovely Are you sure it's AF and not just a bleed.. I guess POAS tomorrow will tell you.

    In terms of Plan B.. what is the go with your frosties? You said you weren't confident in them?


 

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