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  1. #201
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    Quote Originally Posted by Nidhulaine View Post
    Hi Gentay don't worry about not having IVIG before a positive, my last pregnancy (no 8) and my first under Dr M care was a natural pregnancy and an accident as I was not on any immune drugs and only started after Bp including getting intralipids. I lost that baby at 12 weeks after seeing a heartbeat at 11 weeks 5 days but that baby was triploid (3 copies of chromosomes) and incompatible with life. Before that pregnancy I had lost 6 all before 6 weeks in a 2 year period and any D&C pathologies I had came back as normal fetuses. Ironically with Dr M I was able to carry a weaker unhealthy fetus to 12 weeks compared to no meds and losing healthy fetuses at 6 weeks. I felt very unlucky at the time but I do now 100% believe the meds work. Also I didn't start any meds till 4 weeks and they still worked so I think the IVIG as soon as u get a positive for someone like yourself who can conceive naturally will definitely work especially as IVIG is stronger than intralipids. dr M has also recommended Neupogn for me because of the 7 miscarriages.
    Hi Nidhulaine, l'm so very sorry for your losses-my heart goes out to you. Your story is very similar to mine. The only two pregnancies I had tested were my first and last which were both polyploidy pregnancies (tetraploidy and triploidy, both natural pregnancies) which are meant to be random and rare. As I had had two confirmed, I queried whether immune problems could be the cause of the polyploidy and although Dr Matthias and my research both say it is likely to be caused by a bad egg or sperm, Dr Matthias could not discount an immune cause.
    That was food for thought for me and my gut says to err on the side of caution and have an IVIG infusion prior to ovulation if trying to conceive naturally as the miscarriages are too hard on me, especially on my thyroid which takes several months to stabilise post miscarriage.
    Like you, I am a firm believer that IVIG works as my last pregnancy with IVIG was the longest and HCG doubled and even tripled following the infusions.
    Dr Matthias also recommended Neupogen injections on a positive pregnancy test. What was his explanation for this? You say it's because of the multiple miscarriages???
    Prior to undergoing another stimulated IVF cycle, I have to wait until March 2014 for the appropriate PGD testing to be introduced to my IVF clinic as the current testing does not detect polyploidy. Hence, trying to conceive naturally in the interim...
    I have asked Dr Matthias to call me to discuss. Will let you know if/when I hear from him...
    I wish you all the very best on your journey.
    Please keep in touch.
    Gentay
    Last edited by Gentay; 16-12-2013 at 14:40.

  2. #202
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    Gentay, go with your gut on this as well as talking to dr m again. If you think you need the ivig before ovulation and can afford it then go for it. It can't hurt and will put your mind at ease. Do you fall easily naturally? I've had 4 early mcs but always conceive in the first month of trying, it's just been hanging into them that's been the problem. I was lucky enough for my first dr m protocol to work, hoping the same for you! Our next step was going to be pgd as well as we had a triploidy too (mustn't be that rare for 3 of us to have them in the one group) but dr m thought we would be fine without and he was right. Big hugs, I hope you don't have to go through the heartbreak any longer xx

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    Gentay  (16-12-2013)

  4. #203
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    Gentay after doing a bit of research neupogen has been used for women with reoccurring miscarriage and also for implantation problems. It's a drug designed for cancer patients who's immune systems have been depleted during Chemo and it produces more of the good white blood cells(the ones that help embryo implant) in ur immune system. U need to take it till 8 weeks pregnant.

    We we tried IVF with PGD in May and gave one frosty left and as u said I only discovered lately that PGD and the MaterniT21 blood test only check ratios of chromosomes and will not pick up the polyploid fetuses, I even got the all clear on the MaterT21 blood test at 10 weeks.
    Whether polyploid is caused by sperm or egg I suspect is still related slightly to egg quality as logically if the egg has double chromosomes it did not divide properly and if it was double sperm then the egg malfunctioned and let 2 in.
    for me it was late ovulation in a cycle after ivf drugs and I have low amh. Husband has sperm fragmentation rate of 5% ie really good quality so unfortunately I do suspect my egg quality was poor and let 2 sperm in (I had paternal triploid and a partial molar pregnancy). The other thing too is the more times your pregnant the greater chance u have of increasing ur chance of something like this.

    Unfortunately the trauma of multiple miscarriage means u spend more time expecting to lose it and expecting failure. If your trying naturally at the moment then try a uterine scratch. My 3 year old was conceived in a cycle where I had a laprascopy and the scratched area provides a better site for embryo implantation. Just test early and the minute u get a bp get the IVIG, you might be surprised. dr M gave me the following explanation, the scratch stirs up the lining and creates a nice spot for the embryo to implant and the embryo is like a tree. unfortunately my immune system recognises it as not belonging to me and starts to try and kill the roots so the intralipids camouflages the embryo from my immune system. Good luck and hopefully we will both be pregnant soon. Even if I end up on Prozac as my nerves are now shot every time I am pregnant!! Lol!

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    Gentay  (16-12-2013),sootymay  (29-12-2013)

  6. #204
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    @timetoshine: So glad to hear that Dr M's protocol worked for you and others, and first time to boot! What a blessing and congrats!
    I transferred the last of my embryos last month on Dr M's protocol but the transfer was unsuccessful. Thankfully, I have a high AMH and do tend to fall pregnant naturally easily but only after my thyroid settles after a miscarriage which takes a few months.
    Many thanks for your well wishes.
    @Nidhulaine: Many thanks for doing the research-much appreciated.
    Dr M did mention that the more miscarriages you have, the more you are likely to have in the absence of immune treatment.
    When do you have the uterine scratch and is it done as an inpatient?
    The Melbourne specialist who administers the infusions for me told me that, if trying to conceive naturally and wanting to have an early infusion, you should have it 7-10 days prior to implantation but also said it was safe to have it after a BFP.
    Yet to hear from Dr M...
    Yes, hopefully we will both be pregnant with a healthy bub very soon... and do try to keep sane in the interim-no easy feat, I know!
    Gentay
    Last edited by Gentay; 17-12-2013 at 06:27.

  7. #205
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    Higirls,

    Can Ijoin this forum. I was trying to gather more information about Immunologyproblem. I read couple of post & found similar story like me. I would liketo share my story with you & want some advice & hope.

    I’m34..we have started TTC in Nov 2011. I conceived in first go. We were veryhappy that didn’t had to wait much. Unfortunately our happiness didn’t go forlong. I had miscarriage in 8 weeks ( 22/01/2012). I had to do D&C. GP adviseus to not to try for 2-3 months. We tried again & conceived in July’12,again had a miscarriage after 5.5 weeks (11/08/2012). Our GP advise us to go tospecialist. We went to see Dr. David Greening on 23/10/2012. He did lots oftesting on both of us. My partner has all normal results. He found high NK CD57 in my uterus biopsy. He mention normal girl have 10% & I had 40%. He putme on 25mg prednisolone/day. After starting it from Oct’12, didn’t conceivedonce L. Dr. greening advised us togo for IVF. We had our first IVF cycle in May’13 without success. We both werevery disturbed & didn’t able to understand that why I could not able conceiving after starting prednisolone. We werevisiting Dr. greening. we have 2 more frozen embryos, so he has advised us togo for another transfer but we were not ready. Then at last in Sep’13, he mentionedus to take other opinion from Dr. gavin sacks but we read too much about DrGamal Matthias, so decided to go with him too. we took appointments for boththe Dr’s. we had first appointment with Dr. Gavin, he saw all our reports &advised us that I don’t have any problems at all. According to him, there arenot much researches available to prove that NK CD 57 causes any problem with pregnancy.

    Thenafter a month we met Dr. Gamal M, he has ask me to go for more blood tests. We sawhim again on 05/12/13 after getting our BT results. He said that there arecombinations of NK cells causing me problems. He prescribed me more vitamins& ask us to go for intralapid treatment in Jan’14. He said I should not beon steroid for such long time. This steroid gave me lots of side effects. He askme to go for Knee scan as well. He also ask me that once I’ll conceived, needto take some injections to protect my baby.

    Does anybody else was on 25mgprednisolone for about a year?? Is our thinking is right that this steroid wascausing us from conceiving? It made us think because before starting this steroidsI have conceived twice naturally, but after prednisolone not conceived once.

    I’mso sorry for long post…Hopefully Dr. M theory gives us positive result soon. Weboth are very depress. Please help us to share your positive stories similarlike us to rebuilt our hope. Thanks heaps for reading our story & yoursupport.

    Thanks,
    Pihu….

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  9. #206
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    B123 - Thank you, I am in the process of consulting with Karen Pace in the U.S (same lady Helenmac is seeing) - and she said the same re. the endo and that al the estrogen can increase this. I've never had cysts before.

    Thx to everyone else for their support, I will let you know... I too & hoping it' just IVF drugs.

    Quote Originally Posted by B123 View Post
    Sooty: i know these test results can rise if you have endometriosis and also if you have cysts on your ovaries. Do you think the pain you had could have been a cyst popping? That is bloody pain full!
    Hope your dr will find out thats its nothing serious!

  10. #207
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    Not good news for me.. Beta at 12dp5dt was 49. Too low. So far we have transferred 5 cgh tested blastocysts (on top of the other 5 cycles with blasts to that resulted in 2 chemicals) & have had 1 ectopic, 1 negative/hcg 5 & now this. Last 2 cycles I've been on intralipids, pred, clexane etc so it's either not strong enough or our embryos despite having normal chromosomes are the issue. I hate the wait and see approach, testing every 2nd day. My ectopic levels started out like this so I'm praying its not another ectopic! Bad timing with flying interstate tomorrow & clinic closure/ FS on holidays until 7 jan. I guess I'll be having all those tests with Dr M to see what the hell is going on before we do another cgh cycle. I'm interested to hear about the neupogen..

    Simpsondesert & Scruffy I remember reading about all your chemicals/failures with cgh embryos on another thread, what treatment ended up working for you? It's so frustrating when cgh blasts don't work!

  11. #208
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    Elarwood, I'm so sorry to hear your result and that you are having to be stressed by closures over Christmas, I hope it all works out for you

    Pihu, welcome to this wonderful thread, I'm glad you've found it, everyone here is a champion and very knowledgeable and great at sharing information and experience. I'm very sorry to hear about your losses and the long time you have been trying through IVF etc without success - YET! It is very positive that you are now seeing Dr M as all the girls on this thread will confirm! I am new to immune treatment so can't offer much advice except that is sounds very wrong that you were on 25mg pred for a whole year, that is not good for your body at all although I don't think it would have affected your chances of falling pregnant. I hope you were/are weaning VERY slowly off the pred though as that I hear is extremely important for you. Make sure that you take really good supplements (Bioceuticals is a good brand - InNatal is a great multi and I would strongly recommend that you buy Bioceuticals Ultra Muscleze magnesium powder and take 800mg a day - the pred will have depleted you of this vital mineral and it is crucial to fertitlity) Also make sure you are taking zinc and all the other vitamins and minerals needed to have your body ready for pregnancy as the pred will have robbed you of many minerals, take care of yourself.

    Also please take heart that you are still pretty young, so don't panic... you are in the right hands with Dr M, make sure you are with a great IVF clinic that you trust and even if they aren't interested in Dr M's protocol, just do it, it's your choice and he is the best at immune treatment in this country!

    I wish you all the best, try and relax and enjoy each other's company over Christmas, knowing that next year is a new year for you full of hope and a new protocol and being cared for properly. Are you off the pred now or weaning still???

    Hi to everyone else, hope you're all ok

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  13. #209
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    Pihu, I am glad you are seeing dr m now, I'm sure he will be able to help you. I'm not sure about Pred stopping you from conceiving but I was told to only start from day of ovulation at 10mg/day and increased to 25mg only on bfp. If I had bfn that month then I would have weaned off it and started again when I ovulated next month. To be on it for a year without stopping seems very off to me. I also hope you are weaning slowly, it can have some bad withdrawal effects if you go to fast. I have just finished after being on it for 6 months and am happy to have stopped but the weaning process took me a loooonnnnngggg time. Big hugs to you, I hope you get some good news next year. Are you going to continue with ivf next year? I specifically asked dr m when I saw him for my results and he said we shouldn't need to so I am sure he can help you make a decision if need be xx

    Hi to all, hope you are doing well

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  15. #210
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    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Achievements:Topaz Star - 500 posts
    Hi ladies

    I'm so sorry I have no time for personals I just wanted to update my news from Cape Town -2 perfect blasts transferred and the Dr said they couldn't be better!! We also have two frosties so we are beyond thrilled! Now we wait!!!!
    Last edited by helenmac; 18-12-2013 at 02:10.

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