Closed Thread
Page 1 of 92 1231151 ... LastLast
Results 1 to 10 of 911
  1. #1
    Join Date
    Mar 2013
    Posts
    47
    Thanks
    82
    Thanked
    31
    Reviews
    0

    Default High Natural Killer Cells #3

    Hi Ladies!
    I haven't posted in ages but have been reading all your updates! Good luck to all those cycling or about to and those still having testing. And of course a huge congrats to those who are pregnant!!! Without the information on this thread I would not have been able to pick myself up after my chemical result from my June South African donor cycle.

    Sooty! I feel for you honey. I know its easy to say but try and stay as positive as you can. But don't beat yourself up for feeling some disappointment. I know exactly how you feel. The decision to source donor eggs OS is such a hugely emotional one and a big financial investment. I wish you all the best. Enjoy your remaining time in South Africa. It's such an incredible place to lose yourself in the two week wait! You have done so much preparation for this trip I know! Remember these are very young eggs and you have all your extra immune treatment to help things along. So glad to hear you made it to Sanbona!

    AFM - I have had a hell of a few weeks of ups and down on this donor cycle. My gorgeously generous friend agreed to donate. But after 3 weeks on synarel she developed cysts and had to have surgery to drain them! I felt so terrible. I could not believe she had not even started stimming and had developed issues and was unwell!

    Thankfully she recovered from the surgery and still wanted to keep going ahead (I was certain that scare would put her off and she would pull out!). Her meds were pulled back and she was on the lowest dose which ended up translating to very slow follicle development and low numbers.

    Before we started we had been expecting big numbers as she had a very high AMH and AFC (but was not polycycstic). While cycling the scans showed 23 follicles but only 6-8 that were developing. I started to panic coz having done so many cycles with my own eggs I knew how many eggs can drop off before transfer!

    Also after my day 21 hysteroscopy before the cycle I got another period even though I was on Lucrin and was told I probably would not get one or it would be very light. It lasted for ages too so that when they did my lining scans I don't think my lining had had a proper chance to build up. It was only just 6 so they upped my progynova. By next scan it had gone to 7.2 so still not great and they also saw a sac of fluid at the top of my uterus! I couldn't believe it. I had never had problems with lining before or fluid! What a time to start!

    In the end we had 9 eggs collected, 2 were immature though. Of those 7 only 4 fertilised! So let's just say it's been a very nervous 5 day wait to transfer today! Two beautiful blastys put in this morning! Also dr said lining looked great and no sign of that pesky fluid! Phew!

    I am just so relieved that we had something to transfer. The others may not make it to freezing but I'm going to just focus on the transferred embies for now. With all the additional measures we have taken to combat the immune issues I am so much more confident of a great outcome.

    Thanks again to everyone for sharing information about Dr M and his testing!

    Fingers crossed!

    pardon the monster post ladies!

    Libelle

  2. The Following 2 Users Say Thank You to Libelle For This Useful Post:

    MGC Bertie  (18-11-2013),StillHope  (11-12-2013)

  3. #2
    Join Date
    Oct 2013
    Posts
    401
    Thanks
    358
    Thanked
    314
    Reviews
    0
    Sooty, I'm so upset to hear what's happening, if might not be as bad as you think, just hang in there girl, there are lots of stories of not such great looking embies making it just fine, it depends when they look at them etc... were they blastos when they transfered? THinking so much of you, you deserve SO much for this to work, stay positive, we're all rooting for you (not literally ha ha)

    Soclose - do you have to come to Sydney for the biopsy for NK cells and is it just bloods going to Chicago? I got the NK biopsy done at Genea my clinic in Sydney and with HCF bed cover, it cost $140 and was done in literally 5 minutes fully conscious, no drugs at all, like a pap smear. I think it's a lot for you having to fly here and go in to hospital etc ($450 for biopsy with Dr M I believe) - it should be able to be done at your IVF day clinic, just ask them for a biopsy to test for NK cells and get a copy of the results - if they don't do it maybe ask for a referral to another clinic near you that does it for NK cells and get it done there... maybe ring around and see? You're in QLD yes? Where abouts? I'd get the biopsy and NK cell results done locally & send them to Dr M - then let him decide if you still need to do more bloods to go to USA? I'm just saying this to try to save you a bit of money and time as it will all get hugely expensive... Helenmac, what do you think from your experience??? If your NKs in the uterus are over 20/mm2 Dr M will put you on Dexamethasone rather than prednisolone and then it's a matter of if he says you're to do intralipid ($650) or IVIg (around $2250 from what I've read?) ... hope that helps?

    AFM - we had an egg collection on Friday morning, only got the one lead follicle and egg... I was so hopeful for this one and even bought $200 worth of progesterone too... unfortunately, for the first time ever, our egg didn't fertilise normally so we wont be having a transfer tomorrow. My FS basically gave me the I'm very concerned, try other options speech but I've decided to go on the pill for 3 months, give myself a rest from all the cycling and have one or maybe two more attempts... for the first time we're starting to seriously think of donor eggs and you girls give me a lot of inspiration but I am so confused and sad about it all... starting to wean off the dex now at least plus I stuffed my face with chocolate cake and cream

    Just wondering if anyone has taken DHEA? anything good about it? - my FS is basically leaving it up to me whether I take it or not - and also whether to go on the pill or not (great! seem to care less and less about you once you're over 40 sigh)... so far I'm thinking not to as I'm older and a poor responder... any thoughts or advice? Don't want to damage what could be my last attempt with my own eggs so probably won't risk it...

    I hope everyone is well and going strong!

  4. #3
    Join Date
    Oct 2013
    Posts
    401
    Thanks
    358
    Thanked
    314
    Reviews
    0
    Libelle, thanks for sharing your exciting news and rollercoaster ride to get to your transfer, well done!!! It sounds perfect, stay happy, how wonderful to be on a 2ww with great blastos!

  5. The Following User Says Thank You to PreciousHeart For This Useful Post:

    Libelle  (17-11-2013)

  6. #4
    Join Date
    Oct 2009
    Posts
    348
    Thanks
    108
    Thanked
    179
    Reviews
    0
    Good luck for your 2aw Libelle. You've certainly had a stressful time getting to this point!

    PreciousHeart so sorry this happened to you. I've been there a few times and know how gut wrenching and frustrating it is. The decision to move to donor eggs is different for everyone. I actually didn't struggle too much with it as I knew at the end of the day it was my best and only chance of becoming a mum and I would do anything for that to happen. I would adopt at the drop of a hat so to be able to carry my baby would be such a blessing. In the end we had to move to donor embryos. I know if I am lucky to get pregnant that our baby will be ours no matter where the egg and sperm originated from. You will know if and when that path is right for you xx. I took the DHEA for a few months and it was horrific! Didn't do a thing for egg quality at all. I was really really angry all the time and went into depression as well. Hair was greasy as and I felt terrible all over. But I have heard a lot of ladies swear by it. I think I was in the minority and that it was too late for me when I started on it. My eggs were already way past their use by date! Again I think it's different for everyone and it may well just help with your egg quality.

  7. The Following User Says Thank You to soclose For This Useful Post:

    Libelle  (17-11-2013)

  8. #5
    Join Date
    Oct 2009
    Posts
    348
    Thanks
    108
    Thanked
    179
    Reviews
    0
    PreciousHeart thank you regarding the biopsy. I asked Dr M if my FS could do it here in Qld and he said they prefer if I go to Sydney as they know exactly what to test for. I'm trying to limit how many times I have to go to Sydney if I can. Like most of us we've been doing this forever and the funds are tight!! So I'm not really sure what to do now. If Dr M charges $650 and if I have to do it at the hospital there will be an excess on my phi plus airfares etc. seems a lot compared to what the basic ivf clinic can do it for. Anyone else done the biopsy with there regular FS? I'm thinking if Dr M wants me to do it with him then that's what I should do???

  9. #6
    Join Date
    Oct 2013
    Posts
    401
    Thanks
    358
    Thanked
    314
    Reviews
    0
    Hi Soclose, thanks so much for your insight into DHEA, sounds bloody awful!!! I'm probably similar to you so will heed your advice... my reservations with donor are that we are so so very blessed to have our little boy from IVF, it's his second birthday tomorrow... I had decided in the hospital that he was the one and that was it for us because it was so hard to get there but then we started trying again and now I'm all confused as maybe I was too optimistic & didn't know about my NK cells till a few months ago - we too would adopt but they make it impossible huh? I won't go on because I am fully aware how very very lucky I am to have a baby and always think who am I to ask for more? I feel so much for you girls working towards your first bubba, it can be the most dark of places to be and I send all my love out to you all...

  10. #7
    Join Date
    Jun 2013
    Posts
    424
    Thanks
    420
    Thanked
    235
    Reviews
    0
    Preciousheart, Libelle, Soclose - thank you for your encouragement and support. Its morning here now and I feel better already, I've rec'd such support and it is such a blessing to be part of these forums.

    Oh girls - I feel for both of you. I don't feel so alone now. Why why why.... we've all got our own heartache and disappointment we are going through.

    Biopsy - I tend to agree. I got mine done by my FS in Melbourne and sent it up to Dr M. Then Dr M ordered the bloods to look at the overall picture and compare what was going on.

    I also met a lady over here that has moved to Sydney from Melb and she said Dr M charges $650 for the Soy & Egg infusion - not the first time I have heard that, yet here in Melb, Dr Nick Logistas does it for $150. Sounds like Dr M has a bit of a monopoly on it, as there are so few a doctors that do it.

    The procedure for me, was like a simple pap smear, in and out within 5-10 minutes, no anaesthetic, it was a breeze. Cant remember how much that cost, may have been just under $200 for the FS to do it, and then the lab that tested it from memory was $400-600 - sorry, cant remember as I just grin and bear the costs at the moment and don't pay too much attention

  11. #8
    Join Date
    Mar 2013
    Posts
    47
    Thanks
    82
    Thanked
    31
    Reviews
    0
    Precious heart - thanks for the well wishes!

    I am so sorry to hear of your cycle result. It's just not fair.

    i just wanted to say I took DHEA for almost 2 years on the advice of my FS and it made no improvement to my egg quality. I was only 34 & 35 at the time too. I was a poor responder so was looking for anything to boost my quality. A friend of mine also used it and she was younger than me and found no improvement. She also found it led to excess hair growth which made her feel terrible about herself.

    My FS ended up taking me off it saying she had not seen the results she had hoped for after it was first presented to her at an IVF specialist conference the year before. Still it must have helped some girls and if its one more trick up your sleeve maybe give it a go. I seem to recall it takes a few months to kick in. I got sick of the constant reminder of my infertility having to take a tablet three times a day even when I wasn't cycling!

    Libelle

  12. #9
    Join Date
    Oct 2009
    Posts
    348
    Thanks
    108
    Thanked
    179
    Reviews
    0
    I hope I didn't discourage you from the dhea PreciousHeart. I always thought my experience with it was rare. It may well be worth you trying. And never ever feel bad for wanting your second precious baby. You are just as deserving as those of us trying for our first.

    Thanks Sooty. I think I might call my fs tomorrow and see if he will do the biopsy here then. I hope I don't get Dr M offside by doing that but if we can save anywhere we can at this point we will, as long as its not to the detriment of Dr M's protocol and treatment of course. I hope you are feeling ok and enjoying SA. I've heard amazing things about that place!

  13. #10
    Join Date
    Mar 2013
    Posts
    47
    Thanks
    82
    Thanked
    31
    Reviews
    0
    Soclose
    after consulting Dr M I decided to get my NK biopsy done again as my previous results dated back to 2011. He looked at those results and commented I had been tested for some but not all types. CD56 showed up for me.

    So at my recent hysteroscopy I asked my new melbourne dr to test again. When the results came back they only mentioned CD56 again with no reference to CD57.
    I was a bit annoyed that it wasn't clear if I had been tested for both and only revealed information I already knew. I forwarded the results to Dr M and he suggested I up my dex. I have not raised the issue with my local dr yet as i had other more concerning issues intervene re my donor but I will query at my follow up consult if I was tested for CD57s as well.

    so my point is if you get the biopsy done locally just make sure you know what it is Dr M wants you tested for and make sure the lab tests for it. My results were through Anapath and came through as a certain number per high powered field. Others on this thread seem to have results expressed differently. I wish I had been clear at the outset about which tests Dr M believes gives him the best information to work with.

    Libelle

  14. The Following User Says Thank You to Libelle For This Useful Post:

    soclose  (17-11-2013)


 

Similar Threads

  1. Replies: 12
    Last Post: 19-06-2015, 00:10
  2. High Natural Killer Cells #2
    By lissyloulou in forum Reproductive Immunology
    Replies: 940
    Last Post: 17-11-2013, 16:30
  3. High Natural Killer Cells
    By helenmac in forum Reproductive Immunology
    Replies: 980
    Last Post: 21-05-2013, 17:39

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
free weekly newsletters | sign up now!
who are these people who write great posts? meet our hubbub authors!
Learn how you can contribute to the hubbub!

reviews
learn how you can become a reviewer!

competitions

forum - chatting now
christmas gift guidesee all Red Stocking
Pyjamas.com.au
With so many gorgeous brands and styles for every season, our pyjamas, nighties, robes, sleepsuits and sleeping bags are lovely for lights out and perfect for lazy days. Get 10% off first order using code bubhub. Be quick offer ends 31/12/16.
sales & new stuffsee all
Pea Pods
Buy 2 Award Winning Pea Pods Reusable One Size Nappies for only $38 (in your choice of colours) and receive a FREE roll of Bamboo Liners. Don't miss out, we don't usually have discounts on the nappies, so grab this special offer!
Special Offer! Save $12
featured supporter
Tribalance
TriBalance is a physio, yoga & pilates studio in Brisbane's inner north, offering specialised women's health physiotherapy services. Weekly pregnancy yoga classes are scheduled at the studio on Thursdays 1- 2pm and Saturdays 1-2:15pm.
gotcha
X

Pregnant for the first-time?

Not sure where to start? We can help!

Our Insider Programs for pregnancy first-timers will lead you step-by-step through the 14 Pregnancy Must Dos!