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  1. #1
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    Default Failed fertilisation after ICSI

    Hi All, just looking for some advice and support. I have just had my 3rd round of IVF cancelled due to no fertilisation, despite getting 22 eggs and using ICSI. My nurse tells me the lab said they were only able to inject 2 eggs, as the others 'didn't look right' and these 2 didn't fertilise. Our first round of ivf also got cancelled, due to no fertilisation of 27 eggs, but we didn't use ICSI, so they were hoping this was the key. The lab did also say at this time that the eggs didn't look right. Our second cycle we didn't even make it to collection, as they had dropped my dose too much, hoping the issues were related to too many eggs=poor quality. I know feel at a loss as to what to do. I haven't yet had a chance to speak to my specialist, but given he didn't really have the answers the first time, I can't imagine he is going to know what went wrong this time. I'm wondering if anyone else has gone on to have successful fertilisation after failed fertilisation with ICSI? I am thinking our next option is to consider egg donor, but want to make sure we have as much information as possible before we go down this path. I do wonder if the medications could have had a bad effect on my eggs...has anyone heard of this happening before? I'm just feeling so hopeless and would love to hear from anyone who has been through a similar experience.

  2. #2
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    I would see another specialist and also read "is my body baby friendly" it has a lot of info about why some couples get lots of eggs yet no fertilisation. You may need to consider seeing someone who specialises in immune issues in relation to IVF. Good luck and don't give up just yet

  3. #3
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    Hi skippy1, Im sorry to here you have had such a rough time.

    Last month we also had fertilisation issues , I had 8 eggs removed, 4 were mature, all 4 were ICSid but none of them fertilised

    They couldnt tell us if it was the eggs or sperm or both, we have another appt with our specialist next week so I will let you know how we go. One thing the embryologist did mention was that maybe adding calcium next time round might help.

    What is your AMH at? and do you have PCOS?
    I have found a few interesting links, you might want to read. http://nextgenfertility.com.au/how-w...ents/polscope/

    http://www.fertile.com/Calcium-ICSI.html

  4. #4
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    Thanks so much ladies. I will definately do the reading you have both suggested and am definately thinking about a second opinion, as I don't feel they know what to do with me, and are saying they have never seen this before.
    Booboo78, I have endometriosis, which was removed last September, but I think they have had difficulty with the PCOS thing, as I haven't been diagnosed with it, as my current AMH is 21.8. but apparently I am behaving like it!

    Maybe it's worth asking about the calcium, but from what I understand so far, without having had any chance to speak with my Dr, the eggs didn't look 'normal' so not sure whether there is anything they can do.

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    Where abouts are you? People on here will be able to tell you whose the best in your region.

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    So sorry for your cancelled cycle, it can be devastating

    What kind of protocol were you on for the cycle? 22 eggs almost seems like OHSS. Usually they say 10-15 eggs max is a good number so that you get more mature eggs.

    Are you on metformin for the PCOS? That can help increase egg quality. Some women also seem to get great results with DHEA for egg quality, though not all doctors will do it. It might be worth changing a few things up before you head down the donor path.

    If you are older than late 30s, that can play a role in egg quality but sounds like your AHM is great.

    I'd def be seeking a second opinion. If you are a tricky case, you might need a doctor who is quite proactive about trying some new things to get you a better result.

  7. #7
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    Wise Enough - I'm in Melbourne....which i guess gives me a few options at least.

    Clemenine Grace - I was on puregon 150 for 10 days for both my first and 3rd cycle and took the trigger on day 11 with collection on day 13 both times. He tried cutting the dose to 75 gonal f on my second cycle, thinking exactly what you said, that if i got 27 eggs on my first cycle with 150 puregon, that i should get about 10 on half the dose, and hopefully they would be better quality. However on this does my follicles didn't get any bigger than 11mm, even after increasing the doses.
    With this third cycle, the thought was to go back to the original plan, but add melatonin and also keep a closer eye on me. Once I had a few lead follicles, they were going to drop the dose. However, my scan on day 10 (which is the last one I had before trigger) was apparently very normal, with only 10 follicles >11mm, and my hormone level was 'normal', so we never needed to drop the dose.
    I wasn't on metformin, as apparently I don't technically have PCOS.
    My husband and I are both 32 and have been TTC for 2 1/2 years. It really is a difficult journey! The hardest thing at the moment is they are saying they haven't seen this before. I also want to know if they can do more testing on the eggs, but my IVF nurse tells me they can't....

    I really appreciate everyone's feedback!

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    The best in Melbourne is Lynn Burmiester at Monash IVF. She has a long waiting list though so if you do decide to get a second opinion I would recommend her and making an appointment now.

    With numbers like that you definitely respond like you're PCOS. I have it and I got 21 eggs on 275 of gonal.

  9. #9
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    I just wanted to say that even if u get high egg numbers it doesn't always mean poor egg quality. Our last cycle we got 30 eggs of which 19 fertilised.

  10. #10
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    Thanks Wise Enough...I have heard that she is good. the doctor I'm seeing is good and I know he has been collaborating with his collugues, so not sure what i want to do. I have made an appointment with my GP to discuss and maybe get a referral!
    Last edited by skippy1; 19-07-2013 at 17:48.


 

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