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  1. #1
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    Default Agonist/Antagonist Conversion with Estrogen Priming Protocol (AACEP)

    Hi, after meeting with my new FS on Friday, he's decided to put me on the AACEP Protocol. I've got a few questions I'd like to ask, but first I'll fill you in on my DP's and I's background.
    My DP has Obstructive Azoospermia which we found out about at the end of 2011 after TTC for a few months. As age wasn't on our side, we took ourselves off to the GP for the standard round of tests and SA. As my DP has two adult children from a previous relationship (21 and 19) we weren't expecting there to be any major drama's, so it was a total shock and real kick in the guts to be given the diagnosis from the GP. My only issue is my age. My AMH was 7.5 when last tested about 12 months ago and apparently that's about average for a woman my age.
    DP and I started IVF/ICSI in May/June of last year. Our first cycle ended up in an early Chemical and the last 2 were straight out BFN"s . My last EPU was a major disaster with only 3 of the 9 eggs collected mature. All of those cycles were long down reg with Gonal-F or Puregon. I started at 225iu and was increased to 300iu on my last cycle. Despite being happy with my FS, I did feel he was a little conservative in his approach and unwilling to try different protocol's/drugs when I asked about them so I decided to seek a second opinion with a different FS (but still with the same company) and after 4 long months, I finally met with him on Friday afternoon(26/4). He has recommended the AACEP protocol for me for no other reason than my age and the fact that my ovarian reserve is diminishing which is to be expected (I'm given to understand this protocol is also recommended for women who are poor responders or for women with premature ovarian failure, neither of which applies to me)
    It's fair to say my head was done in after reading about all the different drugs I'm going to have to take/inject. As I'm a Phlebotomist, the injecting part of the cycle doesnt bother me at all, nor the pill popping My concern is what side-effects I'm bound to experience which really is what I'm wanting to ask about. Have any other lovely ladies done this protocol before and if so, did you experience any major side effects??? Did it make any difference to egg quality/numbers or embryo quality and were you successful??? Our FS has said we can include Saizen as well if we want to but is not insistent that we do which is good because there's no way DP and I can afford the $1500 for the 10 injections I'd need (we're both low income earner's and the extra drugs+natural supplements for this protocol have already added on another $1000 approx out of pocket for us)
    Thanks for taking the time to read my post and any advice/tips or words of warning would be greatly appreciated....... to you all...........

  2. #2
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    Hi Blondeinbrisvegas!

    I am 27 and did the estrogen primming my last cycle. Our issues were MFI and egg quality (I would get lots at pick up -22- but none would be mature!!!). I felt very overwhelmed with the amount of meds but felt pretty ok (I think...it was a while ago!). I do remember being a tad more irritable/emotional but that was all. We also used Saizen (7 injections overall). I know the cost is extremely high (overall we were OOP about $7000) but all that hard work paid off and I am now 35 weeks with my miracle bubba! I truly believe that without that protocol and added Saizen I would not be PG!

    Best wishes to you and lots of babydust!

  3. #3
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    Quote Originally Posted by Abubby View Post
    Hi Blondeinbrisvegas!

    I am 27 and did the estrogen primming my last cycle. Our issues were MFI and egg quality (I would get lots at pick up -22- but none would be mature!!!). I felt very overwhelmed with the amount of meds but felt pretty ok (I think...it was a while ago!). I do remember being a tad more irritable/emotional but that was all. We also used Saizen (7 injections overall). I know the cost is extremely high (overall we were OOP about $7000) but all that hard work paid off and I am now 35 weeks with my miracle bubba! I truly believe that without that protocol and added Saizen I would not be PG!

    Best wishes to you and lots of babydust!
    Thanks for your reply Abubby, firstly, let me congratulate you on your pregnancy....Good on you love!!! Was beginning to feel like I was the only one on this forum to do be doing this protocol!! I really wish we could afford to add the Saizen, but we just cant find the money. Hopefully the other drugs will get us over the line!! Our FS (after I questioned him about why this procedure is not routinely offered) is going to PESA my DP("yeah, I'll drill him" he said) in the hope of getting more mature sperm from the epididymis, if it's a no go, he'll go the TESA route which yielded enough sperm on our first cycle to be frozen for our other two subsequent cycles. Did you stim with Menopur?? I'm going to be (at 600iu a day-300iu in the morn.300iu at night) I'm also on a concoction of natural supplements including DHEA,Melatonin (which I thought you had to take for a minimum of 3 months, but apparently not according to my FS) Anyhoo, glad to hear that you didn't have any major side effects. DP is used to my hormonal meltdowns (PMSx1000) from my previous cycles and usually makes a quick getaway to the backyard (and the sanctuary of his garden) when I'm "losing the plot" Thanks again for replying, was starting to feel a bit alone in all this. Good luck with the upcoming arrival of your much longed for bubba.......

  4. #4
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    Oh, and I also forgot to mention (and ask you) if you had things like Clexane, Nitrodur patches, Progynova,Lucrin, Luveris, Prednisone, Orgalutran, Menopur, Pregnyl, OCP in your protocol?? My FS is adding these drugs although I've got no known immunilogical or blood clotting disorders (all blood tests from previous FS came back fine including NK Cells etc). He's taking the "just in case" approach I think. Probably better to be safe than sorry I guess? Just thought I'd ask

  5. #5
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    Yeah I was all of those extras too I didn't stim with menopur, just 100 iu puregon with Luveris, cleaned, Saizen, progenova, provera etc

    By the sounds of all ur meds can I ask if ur seeing a FS at QFG Brisbane?

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    And yes I was also on DHEA and melatonin...loved the sleep I would get on that

  7. #7
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    Quote Originally Posted by Abubby View Post
    Yeah I was all of those extras too I didn't stim with menopur, just 100 iu puregon with Luveris, cleaned, Saizen, progenova, provera etc

    By the sounds of all ur meds can I ask if ur seeing a FS at QFG Brisbane?
    Yep. I sure am seeing a FS at QFG The legendary Dr De Ambrosis Was with another FS (with QFG) but after 3 failed stim cycles, I wanted a second opinion and a FS who wasn't so conservative and who also specialises in older women (like me) plus he's a bit of a maverick and a cowboy and I like that!!!!He calls a spade a shovel and has a great sense of humour to boot!! Yes, I've also found the Melotonin knocks me clean out every night!!! Is fantastic!!!

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    Oh yey!!! Wazza gave us this miracle!! He is an amazing man!! Do whatever he says to do! All the best!!

  9. #9
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    Am doing it love, am doing it!!!! I've shot Kate the nurse off an e-mail this morning because the "not doing the Saizen thing" is playing on my mind. I've asked her to ask Wazza does he think it benefit me specifically to do it this cycle?? If he says yes, I'll find the money somehow. Wazza also mentioned having an Endometrial Scratch Biopsy done, so have asked Kate to find out, again, if Wazza thinks it will be of benefit to me specifically and if so how much?? I remember him telling me he can perform the procedure in his rooms, but don't remember being told how much??....Have you had it done??
    I think the DHEA is giving me insomnia as a side effect The Melatonin knocks me out,but for the last few night's I've been waking anywhere from 3am-4.30am FFS!!!! Am tired and feeling a bit over it already!!! I read one of the side effects for DHEA is insomnia....Just want my body to hurry up and adjust!!! Hope all well with you as you count down the days....

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    Hi BlondeinBrissy, - Just thought I'd bump your thread as I will start on this protocol (with WDA) in a few months time, and am interested to hear your, and anyone else's progress. The few months is more to do with DH's work commitments rather than anything else, although I don't think it will hurt to be on DHEA for a few months longer.

    I hope you are sleeping better now. This is only my 4th day on DHEA and melatonin, and so-far I'm sleeping really well. I hope it stays that way. Its about time one of these drugs had a good side effect.

    Abubby, - Congrats on your pregnancy. Only a few weeks to go now. Happy mothers day!


 

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