Hi . I am completely obsessing over this. I have spent all day googling this and finally decided to post on here to get peoples thoughts, advice and stories similar to mine?!! I am 30, weigh 54.5 kgs and am 13 weeks pregnant. I had my 10 week blood tests done and last week went for my 12 week scan. I have been told I have a high risk of down syndrome. The nuchal fold was measured at 2.5 (which the radiologist supervisor told me was within normal range at the time of the scan) Free Beta hCG is 0.661 MoM and PAPP-A is 0.321 MoM. My doctor didnt explain any of these numbers to me, just told me I had a 1 in 188 chance of having a baby with Down Syndrome (my two previous births had a 1 in 15000 chance so big difference)and sent a referral off for me to have an amnio done in 3 weeks time. The last 24 hrs since I found out has been torture, I can only imagine what the next 3 weeks plus time til I get results is going to be like! So Im wondering a few questions... I thank you in advance x 1. Is the 2.5 nuchal measurement within normal range or was the radiologist fibbing??!! and if it is does this mean it is my blood test results that have placed me at high risk? 2. What is the healthy range for the Free Beta hCG and PAPP-A at the 10 week blood test? ie. how far "out" are my results? Just a little or a lot?? 3. Has anyone or does anyone know of anyone who has had a miscarriage from an amnio? 4. Has anyone had an amnio done at King Edward in Perth? 5. Has anyone or does anyone know of anyone who has been high risk, had an amnio and told everything is fine, but still given birth to a baby with down syndrome? Ive heard that amnios are 99.8% accurate, Ive read they are 100% accurate, yet been told the amnio gave a false reading for a friend of a friend as they didnt "test the whole sample" Is it common practice to not test the whole sample? 6. Are you allowed to have a second amnio to get a second opinion? 7. If (and Im only saying if) we decide to terminate the pregnancy due to a positive down syndrome result , I am guessing I will be somewhere between 17 and 19 weeks. What is the procedure for termination at this stage? I know of someone who terminated a pregnancy due to spina bifida and was induced into labour and gave birth to the baby (which passed away hour after) I am not sure how many weeks she was and am wondering if this would be the case in my situation? 8. I had about 6 or 7 weeks of brown discharge (like I would get at the beginning of a period) with the occasional pink blood which the doc had no explanation for other than a possible miscarriage going to happen. Could this have any effect on the blood test results? 9. Are there any other reasons for the blood test results to be out other than down syndrome? I read somewhere that someone in a similar situation was told that they may have had brown and pink discharge due to the early loss of a twin which could have obscured her results???In my 6 week dating scan the radiologist thought for a split second she saw a second sac and there is twin history in the family although there is now definitely only one baby. PLEASE HELP ME BEFORE I GO CRAZY!!!