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  1. #1
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    Default 1st IVF cycle - 27 eggs but no fertilisation

    Hi All,

    I'm new to this site, but given recent experience with 1st IVF cycle, I'm looking for support/advice. My husband and I have been trying to conceive for nearly 2 1/2 years. My FS thought it was due to endometriosis, so I had a lap in September to clear all of this out. However, post lap, we still haven't been able to concieve. We had our first IVF attempt this month. I felt very lucky, as I tolerated everything really well, and when I went for egg collection last monday, I was really happy to be told they got 27 eggs!
    However, I tried not to get too carried away, and was aware there was a possibility of none of them fertilising, as i had heard of this happening before (and we weren't doing ICSI as no identified issues with sperm). However, I was devastated the following day, when I received a call from my nurse saying none had fertilised and they were concerned i had 'abnormal eggs'. I spent the following 24 hours beside myself, before I saw my specialist. He was a bit more positive, and said he wasn't sure what the problem was, and that on the day my eggs were retrieved they looked normal, it was only the following day when the lab went back that they didn't look 'right', they were a bit 'crumbly' and some had more than one sperm in it. My specialist can't explain why this has happened, and is doing some research. He is keen to try again, using ICSI, and possibly lower stim doses.

    I'm really keen to hear from anyone who has experienced somthing like this? In particular if anyone has any advice on what could be done differently, and whether people have had success in future cycles? I'm really nervous that maybe there is a problem with my eggs and that's why we havne't been able to conceive...I'm not sure IVF is going to help

  2. #2
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    Oh skippy how devastating after such a big haul, you must have been really sore. I have not personally experienced this but have read a lot about women who had bad egg quality and there is a lot they can do to improve it. I hope you have a more successful round next time hugs

  3. #3
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    Thanks wishful! Actually, other than being pretty bloated after EPU, I was pretty good, so I fell really lucky in that respect! Yes, fingers crossed for next time, hopefully it was just a one off. You hear lots about 'poor quality' eggs, but not so much about 'abnormal' eggs, so not sure if there is a difference! Also, after speaking to my specialist, he didn't think it was necessarily 'abnormal' eggs as he spoke to the lab, and they said they looked normal after collection, but couldn't explain what happened. This process certainly teaches you to be patient doesn't it?!

    Congratulations to you! I hope you are well with your pregnancy!

  4. #4
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    So sorry to hear, IVF is the biggest roller coaster ever...

    My first cycle at EPU they retrieved 20 eggs, 5 fertilized, 3 made it to day 2. 1 transferred & BFP but sadly miscarried... The last two FET ended in BFN

    I left MIVF as I was not happy & moved to Monash.. She was great I too had a lap & have mild endo & mild PCOS - DH has high number of abnormal sperm morphology.

    Next cycle we lowered my dose as i had OHSS with the 20 eggs collected. My FS was going for quality over quantity but the problem this time is my dose was to low, so cycle was cancelled before EPU so we didn't waste our money..

    The 3rd cycle my FS added Menupor to help with egg quality. I had 14 collected, 7 fertilize & 3 made it to blastocyst stage...

    We do ICSI, I next time would at a minimum ask that half your eggs be ICSI'd

    Maybe ask about Menupor or down reg cycle

  5. #5
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    Thanks skippy!!

    It's so hard as everyone is different and we all turn to ivf for different reasons, I hope that you have a better round next time good luck 😊

  6. #6
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    Hi skippy,
    It must be devastating to have this happen . 27 eggs is a huge haul- you are certainly a high responder to the stims.
    In my own icsi cycle the FS took out 16 eggs and he said this was a little high too. He said sometimes too many eggs compromises the quality.
    Perhaps you doc needs to stim you more slowly or carefully so your follicles grow well.
    Icsi is great for higher fertilisation too.

  7. #7
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    Thanks so much everyone! Yes, initially my FS was talking about using the same protocol next time, as I tolerated it so well, but just adding ICSI. However, after speaking to him the other day, he has done some research and is thinking now maybe a lower dose, as well as ICSI. I will definately ask about menupor too!

    Thanks again!

  8. #8
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    skippy1, you should definintely consider lowering the dose and adding ICSI. You are probably like me, sensitive to the drugs so you produce a lot of poor quality eggs. Ask your FS to lower the dose, you should get less eggs but better quality. I wouldn't waste time with natural fertilisation. DH has strong good quality swimmers and we found ICSI works better.

  9. The Following User Says Thank You to Rachael3 For This Useful Post:

    skippy1  (21-04-2013)


 

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