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  1. #281
    helenmac's Avatar
    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Scruffy - I'm so sorry your HCG levels have dropped It sux when you come so close with a chemical. Are you thinking of trying again? If so perhaps you can try IVIG next time? I wondered why Dr. M didn't suggest IVIG for you especially if you have high nk cells in the uterus. Perhaps your body just needs the more agressive treatment for a sticky one. Wishing you all the very best and take care.

  2. #282
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    Default High Natural Killer Cells

    Thanks everyone. Helen I asked Dr M how he decided and he said it was just down to severity. I thought the CD 57 NK cells were the worst but I have to trust his judgement. Yes I will push for IVIG next time. Hoping to do an FET in Jan if I get a normal embie from the batch being tested.

  3. #283
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    Hi all

    Need some serious advice...saw Dr S last night & discussed my nxt cycle, told him I was still seeing Dr M & that I was looking at IVIG or Intraplids to help. He thinks it's not necessary & that Dr M charges high amounts for treatment which is not proven to be any better then the Prednisolone treatment he uses...he highly recommends I screen my embryos & go down the CGH path as logically I need to be 100% sure my embryos are genetically normal...he said immune treatment is easy but we need to test to see how my embryos are...he thinks if anything do both? From what I have read & seen CGH doesn't prove anything as people still don't fall pregnant with perfect genetically tested embryos so my question is what should I do? We have decided this will be our last cycle so am I best just to do the CGH & Dr Ms treatment to cover all my bases & know I tried everything? Or am I wasting my money on the CGH? Another thing is that I won't be able to cycle until Feb as they aren't doing the CGH until then? Soooo confused!!


    Kiwi

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    Hi Kiwi,

    I'm not sure how good my advice is but here it goes...

    I was never encouraged to do CGH testing. Both FS and Dr M said that as my karyotyping had come back normal there was no reason to suspect anything was wrong with my embryos. There is a section in Dr Beer's book that talks about why he doesn't really believe in CGH testing and feels it's an unecessary expense. I'll have a look when I get home tonight and see if I can find it and quote it for you, might help you with the decision.

    The other thing you need to consider is will you regret it if you don't do CGH testing? Would you feel better knowing that you'd thrown everything at the cycle?

    The worst thing about seeing multiple specialists for the same issue (or so I've found) is that they all plant little seeds of doubt about the other doctors in my head! Even this week my OB is telling me how bad it is to be on med-high dose Prednisolone during the 2nd trimester as it increases the risk of membranes rupturing (small increase), making me wonder if Dr M should wean me off sooner!

    I hope you are able to make a decision that feels right to you.

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    Scuffy, Im so sorry to hear the news! big hugsbe gentle on yourself...

    Kiwi, I haven't been exposed to CGH testing issue so can't help you there, however, I do know about 'throw in everything in the last cycle so you don't have any regret' as it is what Im doing right now. Although have no idea how expensive CGH is...hope that is feasible for you. Best of luck of finding the solutions.

    Bella, what you said about 'planting the seed' is so true...I have opted for not telling my FS (who is Dr. Sacks) about following Dr. M's protocol this cycle, so I have been a bit naughty. However, didn't feel so bad since he wasn't even there for my transfer anyway...

    I checked my bondi protocal regarding when to wean off Pred, it says from 12 weeks onwards as well...I know a lot of ladies been on this protocal and had no major issue with membranes, Im sure your OB is just being cautious or maybe hasn't been exposed to patients like us with immune problems. 35mg pred will scare any normal people let alone used on pregant women if we haven't had any experience in this area...Do you know how long it will take you to completely wean off pred? Has Dr. M given you any indications?
    Last edited by Earthpower9; 13-12-2012 at 12:45.

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    Scruffy - I'm thinking of you. A chemical is so hard.

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    Hi ladies
    Hope you dont mind me jumping in here, i'm not actually ttc at the moment as i finally have my beautiful bub after many years of ivf and losses...i had treatment with Dr M and I am almost certain that he helped get me 'over the line'.

    I saw this thread that Helenmac ("hi") started a while ago but have not kept up to date sorry, but hope to from now on and see you all get your sticky BFPs

    I wanted to reply to kiwi77 as Dr S was also my FS this last cycle and he too said similar things to me...he was always saying my eggs were no good (as i am a poor responder) and that Dr M treatment was unneccessary. i would try to argue that i had fallen pg 4 times in a row and m/c around 7 weeks and that the last two D&C's showed bubs had normal chromosomes. He said his immune treatment would be enough for me however i had been on his 'bondi protocol' the previous 2 cycles and still miscarried with my previous FS (Dr S is not the only doctor who can use prednisolone & clexane). I was willing to try EVERYTHING this last cycle so added luveris, growth hormone and Dr M's treament with Intralipids and luckily DD made it here safe and sound!


    I am not sure about CGH testing as it wasn't even an option for me as i only ever got a few eggs and i only had one lonely embryo for transfer. I think it is pretty expensive anyway...maybe even more expensive than intralipid or IVIg??? Did Dr M say which one you would need? I ended up having 4 x intralipids ( at $650 each) during my pregnancy ...the absolute BEST money i ever spend after years of failed ivf cycles!!

    Just wanted to tell my story, dont know if it helps?... i just know that i too was going into our final cycles before moving down the adoption road and i wanted to throw everything i could into it...i was on soooo many drugs it was ridiculous but worth it all!! My Ob was always scaring me about the prednisolone during pregnancy and was almost blaming the drug on my bub being small and having a small head (had a very stressful pregnancy!!) but she is just little!!!....and perfect...no ill effects at all from all the drugs. Dr M knows what he is doing and he is one of the few doctors throughout this whole long and sorry journey who i truly trusted.

    Sorry for the long post, but i hope to help anyone out there considering his treatment. feel free to ask me any questions.

    Cheers
    YY
    Last edited by YinYang; 13-12-2012 at 13:34.

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    Earthpower9  (13-12-2012),festivalgirl  (13-12-2012),helenmac  (14-12-2012),kiwi77  (13-12-2012),Romy Sydney  (13-12-2012)

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    Im at work but just want to pop in quickly to say a big THANK YOU to YingYang to share your story with all of us, I have tears reading it and so similar experience...thank you for giving us hope!

  12. #289
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    Default High Natural Killer Cells

    Thanks for your story Ying Yang. We all need a bit of how is this thread.

    Kiwi I do CGH as I have a balanced translocation. Only 2 out of 6 embryos are 'normal' so for me the expense of CGH is cheaper than the cost of putting back in so many duds. You do tend to lose alot of good embryos getting them to day five blastocysts and I often wonder how many good ones are lost along the way.... But I am also of the theory to throw everything at it and bugger the cost (if that's possible)
    Good Luck with your decision and I hope time flies for you

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  14. #290
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    Default High Natural Killer Cells

    Ooops hope not how!!


 

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