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  1. #91
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    Hi ladies

    Just a quick one from me. Had EPU yesterday - got 13 egss, 11 suitable for ICSI. Of these, 6 fertilised. This is a much lower fert rate than we've had previously - scientist said the eggs that didn't fert looked like they had a structural problem. (Another thing to add to my list to worry about!)

    Just hoping that the ones that did fertilise are strong enough to keep going.

    Transfer on Monday, BT on 19/10 Back on Clexane today after 3 days break for EPU and also started antibiotics as per Dr M's instructions.

  2. #92
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    Bella - my fingers are crossed for you and your six fertilised eggs. Grow little ones grow.

    I have had some very bad news - my fertility specialist has just confirmed with us that he is cancelling our cycle. I got a high progesterone reading yesterday of 7.5 and we triggered anyway last night in case it was an aberrant reading or in the hope that it went down. Re-tested this morning and it has jumped to over 20. My FS said that it is highly unusual but that I am "busting through" the drug which stops ovulation. In my case this was Certrotide.
    My FS has recommended that we try naturally just in case as I only had 3 viable follicles so highly unlikely I would end up with a multiple pregnancy especially as we usually use ICSI.
    As you can imagine we are devasted. Gwyneth is chasing Dr M (on holidays) to find out if I keep taking the prednisone and clexane whilst we are trying naturally and if I need to take the doxycycline as well or if that was only if we had an egg pick-up and transfer.
    I usually respond well to stimulation so this is something very new for me. Lots of variances on usual of course: DHEA and using Gonal F/Certotide instead of Puregon/Orgalutran and prednisone, clexane and IVIG. From the start my numbers havien't been good estrogen up and down and now high progesterone. My FS says he may consider a back-to-back stim cycle next month. So will think about that if we don't manage a natural miracle. Or may wait to try again in November.

    Kiwi - nice to hear from you, good luck for Friday, make sure you ask LOTS of questions

    Wishing everyone all the best as always. FG

  3. #93
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    FestivalGirl - I am so sorry that they had to cancel your cycle. That is terrible, and so disappointing for you both. Would your FS consider an IUI so you can make sure the sperm is at least in the ball park? (Sorry if that's a silly question, but seems like more of a sure shot than trying naturally when you have invested so much in this cycle with the IVIG and all). Keep us posted on what happens and take care of yourself xx

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  5. #94
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    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Hi Ladies,

    Scruffy - All the best for your BT on the 8th. Hopefully you'll have a BFP so you won't have to worry about an apointment with Dr. M.

    Kiwi - All the very best for your biopsy with Dr M. Yes its a bit scarey those extreme side effects on Humira but it's much more likely to occur over long term useage. All the doctors in the USA & UK will only allow a maximum of 2 courses (& also Dr. M). The reason why I've pushed for Humira now is because I have spent over $15,000 for donor eggs in SA which resulted in a chem preg in June and I now have to fly over to Cape Town for my final FET of 2 embies. It's another huge expense (not to mention the immune meds cost!!). Unfortunately I don't have the option to keep doing cycle after cycle with my own eggs as they have expired! This is our last shot and I made if perfectly clear to Dr. M that I wanted to be on the most aggressive treatment. As for yourself, I can understand the risk may increase so it's a hard one. I have a feeling Dr. M might suggest IVIG and Neupogen for you as that is what he initially suggested for myself.

    Bella - Wishing you the very best for your 6 embryos that have fertilized. I hope they all keep growing. Keep us posted and wishing you well.

    Festivalgirl - So sorry to hear about the cancellation of your cycle. That is so disapointing after investing so much into the cycle. I agree with Bella can your FS do a IUI to give yourself the best chance of fertilisation or is it too late for that? Hopefully a natural pregnancy will occur. Keeping everything crossed that this will be the case
    Last edited by helenmac; 04-10-2012 at 18:01.

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  7. #95
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    Thanks for all the thoughts girls - thankfully my mini meltdown passed quite quickly and me new mantra is "I didn't get AF today so it's a good day"
    I haven't ever made it to BT before so if I make it to Monday I will be very nervous

    Kiwi - to answer your question specifically I am still on the fence about the CGH. Do you have any known chromosomal issues? (I assume they can't isolate the bowel cancer gene?) When we saw the geneticists for my balanced translocation they said my stats were that only 2 out of 6 embryo's would be 'normal' so for us paying the money seemed worthwhile. The total of all my testing batches is 15 embryo's tested and only 5 were normal so I suppose that saved us the heartache of lots of failed rounds....

    That being said it is very expensive and my sister who has the same translocation as me has no fertility problems and three healthy children (she did have three early miscarriages) but always fell pregnant very quickly. So I don't think the balanced translocation is the crux of my issues, hence me pushing for immune testing.

    The one huge positive of testing is when I finally do get pregnant chance of miscarriage are lower and I won't have to go through all the 12 weeks tests. I also have a friend with a child with a disability from chromosome issues and can see how heartbreaking that is. Finally I didn't want to be in the position of being pregnant with a child with chromosome abnormality and have to make difficult decisions.

    So after that very long winded post for me the money is worth it BUT only because of my balanced translocation. I also wonder about the healthy embryo's you must lose because testing is done Day 5 where they may have gone on to be very healthy pregnancies if put back in on Day 3.

    I hope this helps somewhat

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  9. #96
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    Scruffy that's a good sign making past AF due date, I'm keeping my fingers crossed for you on monday.

    Festivalgirl so sorry your cycle had to be cancelled hopefully you can do another cycle straight away if you don't have a natural pregnancy this cycle my clinic has never done any blood tests to monitor me with any of my cycles.

    Bella hope you're feeling ok and embryos are growing nicely, will you have 2 transferred?

    AFM thanks everyone for your support after my consult with Dr M. I know I should be grateful that nothing was found and I don't need to take any full on medications with the added side effects gee the diabex is bad enough! Anyhow started taking my temp everyday and planning to cycle around DH who works away then my clinic calls to tell me they have a donor for me! Murphy's law hey!

    Hey to everyone else

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  11. #97
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    Hi ya

    So my meeting with Dr M went well - he explained there was def. NK activity in my blood results (which was no surprise) he mentioned something of it not being balanced so the shell of the embryo is attacked. He wants to put me on dexamethasone first for 6 weeks then he wants to do the biopsy to see how the drugs are working and if they are actually suppressing the activity in my uterine area. If that works then I can go ahead with my next cycle and he will include IVIG and maybe neupogen. So depending on all of this and the results I may not get to do my next cycle until Jan next year...At least I can drink over the xmas NY period .

    Bella - all my prayers are with your lil embies go keep growing strong!
    Festivalgirl - Im sorry they had to cancel your cycle but hey who knows a natural could def. happen
    Scruffy - thank you so much for all your insight - I dont have any known chromosomal issues just the gene issue which there is a 50% chance I could pass this on to my baby...so if they can rule this out I may look at doing it if not then maybe not....I can understand why you have and you are right knowing there is a lower risk of miscarrying is piece of mind. Stay positive and keep repeating your mantra lots of coming your way!
    Helenmac - I can see now why you are stressing the humira - you have been through a lot... I did talk to Dr M about this with me too but he said lets try the dexamethasone first and do the biopsy to see how that looks and will reevaluate the situation but again with my gene issue not sure if I would want to risk it...
    Gretchen - thats fantastic news you dont have to go through IVF - as one of the ladies mentioned I think Nat had success of clomid as well so Im sure youre on the right track!

    Anyway hope you all have a fantastic wkd!

    Me 34 DH 32

    TTC since 2009
    7 attempts: 2 Fresh Chems; 2 Frozen Chems; 3 BFN
    Diagnosed with extremely high NK cells Jan 2012


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  13. #98
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    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Festivalgirl - Do you have any idea when Dr. M is back from holidays? I need to get my TB results back mid next week before I can start the US bloods. Also with the USA bloods what exactly did you wrap them in? Bubble wrap only and then a box? Did you have to write the address on the box or do First Couriers do that? Thanks. Hope you are going well and good luck trying naturally.

  14. #99
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    Quote Originally Posted by helenmac View Post
    Festivalgirl - Do you have any idea when Dr. M is back from holidays? I need to get my TB results back mid next week before I can start the US bloods. Also with the USA bloods what exactly did you wrap them in? Bubble wrap only and then a box? Did you have to write the address on the box or do First Couriers do that? Thanks. Hope you are going well and good luck trying naturally.
    Helenmac, I had my meeting with him on Fri over the phone so he must be back....they are also sending me the script in the post so is it an option for you to do the same?

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    Hi everyone, sorry for being MIA, seems so much happened!

    Festivalgirl, Im so sorry to hear your news especially this is the 1st time on Dr M's protocol and you have invested so much! Did FS say why the change of course using different drugs if the past stim cycles worked well? I know Puregon/Orgalutran combo worked really well for me and always produce good result, while I tried two antagonized cycles with different drugs and trigger, the result was very poor! So different drugs will definitely have an impact (don't think DHEA will play much of a role though). See how the natural will work this month, otherwise, maybe suggest to FS 'if its not broken don't fix it', or maybe try to change one/two elements at the time so at least you know what is affecting the cycle result? Fingers cross for you for a natural miracle for you though!

    Bella, glad you have 6 eggs fertilized! That's a good result, don't forget you only need one, maybe will have some snowbub saved as well! Im cheering you on for this cycle! When is the transfer? Are you transfer a 3-day or 5-day embie?

    Kiwi, did you say you have a biopsy on the 9th? Me too, together with a hysteroscopy. Glad you had a good meeting with Dr. M, the suggestion of dexamethasone is interesting before the biopsy. Have you had one done before? Regarding PGD, if I may offer an opinion, I would really be making immune issue as a priority then maybe consider PGD down the track. I had similar experience with Dr. Sacks before, 3 cycles with bondi protocol and this was the same thing he suggested to me as well, my gut feeling (at least for me) tells me managing the immune (NK) issue is the key. Good luck on making the decision, I know its so hard!
    Scuffy, I have everything crossed for you for a BFP on Monday!

    Helen, Im so glad Dr M agreed on your terms! I totally get you want to invest as much as you can for this last shot, same with me....we are the 'last shot buddies'now! Where are you at the moment? More tests?

    AFM, having the biopsy procedure next Tuesday, although I heard its a very routine and small procedure, I shouldn't worry, but its kind of play on my mind. Luckily, Sunday is my DH and my mum's birthday, so hopefully that will distract me a bit! I will report back once I had this done...
    Last edited by Earthpower9; 06-10-2012 at 22:44.


 

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