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  1. #1
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    Default Compound heterozygous MTHFR...now what?

    Hi all,

    Just got the results today that I am a compound heterozygous for the MTHFR gene...I have a few concerns and any insight would be greatly appreciated. We have been TTC for 2 years and are about to start our 5th IVF cycle (1stim,2xFet,1cancelled) I have never had implantation occur.
    My questions are
    1) what treatment did your FS offer?
    2) have you managed a successful pregnancy
    3) did you encounter any skepticism from your FS or have them ignore the mthfr result?
    4) if you did achieve a BFP did the blood thinners if taken make you a high risk pregnancy?

    I go to a very conservative clinic and actually got tested for this by my GP on a naturopaths advice so will be discussing this with my FS next week but I'm scared he will dismiss it and not offer any treatment or look into any further.

    Any info would be greatly appreciated xx

  2. #2
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    Achievements:Topaz Star - 500 posts
    Hi Hope - I am heterozygous MTHFR too among other things. In answer to your questions

    1 - I was put on Mega Folate (5mg, normal folate is .5mg), Mega B and baby aspirin (cartia)

    2 - Yes, finally on my 8th and final transfer. I did have other problems though so was on other medications too

    3 - The FS I saw (only once, my FS left the clinic) didn't tell me about my MTHFR, I found out when my midwife requested my BT results from Clinpath. Unfortunately I had a missed miscarriage not related to MTHFR but changed to a different FS at my clinic & never looked back. He's well known for dealing with the "harder" cases and is quite successful in getting them pregnant.

    4 - No the blood thinners didn't make me a high risk pregnancy, I was on clexane as well as aspirin.

    Not sure which clinic your with but have a feeling it's Flinders? I was with Repro.

    Good luck with your IVF journey & I hope you get your BFP soon

  3. The Following User Says Thank You to hoping4asticky1 For This Useful Post:

    Hope2487  (25-07-2012)

  4. #3
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    Thankyou so much hoping! So appreciated, yep I'm with FRM & will be pushing for something when we see FS next week but don't like my chances! If they'll not offer anything else we think we will relocate to repromed as they seem to be more proactive - the nurses have been lovely but unhelpful and the FS is very much as natural and conservative as possible .Congrats on your BFP cycle & Thankyou for your answers :-D

  5. #4
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    I'm also heterozygote MTHFR. Similar story to Hopingforasticky. I'm on 5mg folate and a multi-B vitamin. Besides that my fertility specialist and obstetrician don't seem worried about it at all. It certainly doesn't make a pregnancy high-risk on its own. I'm on blood thinners for another reason, and everything together makes it a high risk pregnancy (IVF/miscarriages/twins/coagulopathy) but I'd say the MTHFR is the least of my worries! Good luck:-)

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    Oops - sorry! Missed the 'compound' bit, which makes it all a bit more complicated:-( Have you had your homocysteine levels checked? Means some FS would put you on clexane, which isn't so bad. The most important thing is that you know about it, so you can take steps to minimise the risks. Make sure you find someone that you trust and that you can talk to easily.

  7. #6
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    hi I just found out i have mthfr. My integrated doctor has put me on methyl guard forte. You can actually buy it online. Its basically an active form of folate as we do not absorb folate with this defective gene. Worth covering off if you are having miscarriages like me.

  8. #7
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    Hello in not sure if you ladies are still on here but I have just been told im compound hetro. I was told to take 5mg of megafol. Pharmacists are saying that I wont process it. Im so confused and think ive google too much. Hoping4asticky1 was mega folate bought in australia? Im trying to figure out what vitamins to take. Please please help xx

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    So my understanding of all this is you need to be on an 'active' folate because your body can't process the standard folic acid. I'm not 100%

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    Crap, hit send by accident. I'll keep typing.

  11. #10
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    I'm not 100% megafol is ok to be honest. There is actually a MTHFR folate through Thorne which I know a lot of people take. Who tested you for this and what advise did they give? There are specialist who focus on immune problems, may be best going down this path to ensure you're on the right track. Just my advise.


 

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  1. Does anyone have experience with MTHFR?
    By Rutabaga in forum IVF
    Replies: 11
    Last Post: 17-12-2013, 21:08

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