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  1. #11
    helenmac's Avatar
    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Thanks YY for all the info I really appreciate it.

    It's interesting in what you say that Dr. Sacks claimed your CD57 were higher and Dr. M said it was CD56 were the main problem. What I understand is that CD56 is easier to treat then CD57 and unfortunately I have high levels in BOTH!! (according to Dr. Sack's testing).

    To be honest I didn't really want to go through another biopsy because the previous one with Dr. Sacks stuffed up my cycles and it delayed ovulation. I am hoping to have my final FET (donor cycle in Cape Town) ealy September but perhaps that won't matter cause I'm on the pill anyway to regulate my cycles and it's easier to have control of the timing etc on a medicated FET.

    Can I ask where did you have your biopsy with Dr. Matthias and how long after did you do IVF? Does he just do the biopsy without the hysteroscopy? Do you remember how much approx it is? Sorry for all the questions. I know I'll find out next week when I speak to him but I'm anxious to know everything now!

    Anyone else out there treated by Dr. Matthias????

  2. #12
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    Hi Helen
    I first saw Dr M mid-March last year and had the biospy around mid-May then did IVF cycle end of June. Biospy done at Hurstville private, can't remember exact cost but maybe around few hundred$$. Could ask if it makes any difference not doing the hysteroscopy, I just went with whatever he suggested, think he want to be sure himself there are no physical issues as well...actually he found I had a very slight bi-cornuate uterus which I didn't find out until I had an early scan when i was pregnant this time, he didn't think it was even necessary to mention it to me as would not be a problem for pregnancy (but I do actually wish he had told me earlier!). Anyway, I also asked for him to do a pap smear 'while he was down there' and he was ok to do that too. The biospy is timed for towards the end of your period, cant remember exact time frame but i think i had mine around day 28.

    Maybe also ask him about the drug Humira, used for CD57 cells, I think he also uses this sometimes but said i didn't need it given my results.

    All the best with the phone consult, ask lots of ?'s he's very warm and approachable and will take the time to explain everything.

    YY

  3. #13
    helenmac's Avatar
    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    YY thanks soooo much again for the info. Funny I just did a search on Humira on bubhub and this post came up as I didnt' realise you had responded so soon.

    I've been thinking about Humira as I'm fully aware that in the USA & UK they highly recommnend you use it if you have the uterine high CD57 cells and the Dr. Beers book Is your body baby friendly explains this is the only treatment to deal with these agressive cells in conjunction with steriods and/or invig or intripilids. I hadn't really heard of many women using humira in Australia so I assumed it was a drug that was'nt easily available. I'm very pleased to hear that he prescribes it, whether or not he will decide to treat me it's given me a sence of relief that it could be an option.

    Thanks!!!
    Last edited by helenmac; 06-07-2012 at 09:04.

  4. #14
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    Found this thread after posting on another and thought i'd try here also.

    My DH and I have unexplained infertility. DH sperm is fine and we produce a couple of good blasts each time. We had 3 failed stim cycles and one failed FET. Two of the stim cycles we transferred 2 embs each. This current cycle transferred 2 blasts and I know it's also a negative. Unfortunately embryo's just don't stick and I've been saying this for a while to DH that my body is fighting them off.

    I brought up NK cells with my FS (currently with Genea at Kent St) he didn't seem too keen and said it's another one of those theories that come and go. After calling him to ask a few more questions I brought it up again and he said he wouldn't rule anything out.

    I am nearing the 2nd half of my 2ww and feel nothing and know it's a BFN so would like to prepare myself with next steps.

    1) In my situation do you think it's worth getting these tests done? Hate to waste money on another cycle without knowing for sure everything is ok.

    2) Do you think I should go through Dr Matthias as he is an immune specialist (not my FS even though Genea could perform the test).

    3) When would I go in for the test during the cycle? My AF is due on the 15th July so I will start my next IVF cycle on the 15th August. Will the biopsy interfere with my upcoming cycle chances?

    Hope you can help with these questions and we find some answers to our battle.
    Last edited by Rachael3; 06-07-2012 at 09:05.

  5. #15
    helenmac's Avatar
    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Hi Rachel,

    If you want my honest opinion if I was you I would push for the high NK testing. I've read that women with endometrios are more likely to have immune problems. If you don't have it then at least then you have ruled it out and it's peace of mind. I had mine tested after 2 failed FET's as I knew the embryos were of great quality so I knew it had to be something that was preventing implantation. I just had a hunch.

    Only you can decide on if you get the testing done with Dr. Matthias or with your current FS. Just remember Dr. M isn't an IVF doctor so you would need to stick with your FS for the IVF. The biopsy is performed after ovulation a few days before your AF is due (when implantation would occur and the NK cells are at there highest). The biopsy mucked up my cycles a bit and my cycles were extremely long for a few months. It delayed my ovulation so I think I had one cycle 56 days long and another 50 days long or something like that. It was extremely frustrating but that doesn't happen to everyone.

    I wish you well with whatever you decide.

  6. #16
    helenmac's Avatar
    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Hi Ladies,

    I had my phone appointment with Dr. Matthias and he was so lovely. We discussed all my medical history and he's suggested I have more immune testing (blood tests) and if they are all clear we'll discuss his recommended immune protocol. If they are not all clear then further extenstive blood testing is recommended and more bloods will be sent over to Chicargo.

  7. #17
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    Thanks helenmac for your reply I just had a confirmed BFP yesterday so hopefully I won't need to see him.

  8. #18
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    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Rachel - WOW Congratulations on your BFP!!!! That's so exciting!!! I remember you weren't very convinced this one worked so what a lovely surprise. Wishing you all the very best for the next 9months!

  9. #19
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    Default Undergoing treatment with Dr Matthias

    Hi Ladies,

    I have just had my second appointment with Dr Matthias and last night got the results from my blood tests (from Chicago) and biopsy from Dr Matthias. He has confirmed immunological factors have been interfering with implantation and following implantation leading to miscarriage or chemical pregnancy. So that explains the last 5 years!

    I have high CD56 and TNF alpha? and also imbalance between NK and TRE6. My natural killer cells count is 81.

    He has recommended I go onto prednisolone for 3 weeks prior to my next cycle. Clexane. Vitamin E. Caltrate Plus. And also an IVIG infusion before the transfer.

    I have transferred to Dr Reid at Genea to do the IVF part.

    Fingers crossed for everyone.

  10. #20
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    helenmac is offline After 3 yrs of tcc I've got a BFP!
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    Hi Festivalgirl,

    I'm sorry to hear about your troubles with implantation over the last 5 years!! I can totally relate. Thankfully now you have a proper diagnosis you can now be treated accordingly and you are in the best hands with Dr. Matthias.

    Can I ask how long did it take to receive the blood test results back from Chicago and how much did it cost? Also how long after the biopsy did you get the results back?

    I'm booked in for a biopsy in two weeks. I've had one previously with Dr. Sacks but Dr. Matthias wants to do one himself as he does them differently and will look in with a microscope to have a closer look at the uterus and lining.

    When is your IVF taking place? Wishing you every success!!


 

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