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  1. #371
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    Hi Ladies

    Kel the Downs scan is called the Nuchal Translucency NT for short.

    In the fetus fluid collects behind the neck, much like it does in dependent ankle oedema in later life. This occurs partly because of the fetus’s tendency to lie on its back and partly because of the laxity of the skin of the neck. As with ankle oedema this accumulation of fluid can represent the end point of several pathological processes, including heart failure. Fluid collecting behind the neck can be detected as nuchal translucency by ultrasound scanning, and it can be measured. The more fluid that has accumulated, the greater the risk of an abnormality being present.

    Chromosomal abnormalities—for example, Down’s syndrome—can cause fluid accumulation. Chromosome 21 contains the gene that codes for type VI collagen. In trisomy 21 one subunit of this collagen can be overexpressed, resulting in connective tissue that has a more elastic composition.
    Failure of fetal movements is also likely to cause nuchal thickening. Neuromuscular abnormalities can cause poor breathing and body movements, both of which may lead to fluid collecting as happens in peripheral oedema. One example is arthrogryposis, which causes contractures and flexion deformities and can be fatal. Other causes are intrathoracic and extrathoracic compressive syndromes. If the thoracic cage is abnormally narrow or an intrathoracic lesion is present (such as a diaphragmatic hernia) the vessels in the fetus’s head and neck become congested and oedema occurs. Likewise, if heart failure occurs (due to congenital cardiac abnormalities or cardiac dysfunction) more extravascular fluid will form.

    There is a brief opportunity between 10 and 14 weeks’ gestation (when the fetal lymphatic system is developing and the peripheral resistance of the placenta is high) to detect abnormal fluid collections. After 14 weeks the lymphatic system is likely to have developed sufficiently to drain away any excess fluid, and changes to the placental circulation will result in a drop in peripheral resistance. So after this time any abnormalities causing fluid accumulation may seem to correct themselves and can thus go undetected by measuring nuchal translucency.

    About 90% of fetuses with a nuchal translucency measurement of 3mm (“high”) at 12 weeks’ gestation are normal at birth, while 10% have major abnormalities. Only 10% of babies with a measurement of 6mm (“very high”) at this time will be found to be normal. In centres that perform nuchal translucency measurements, once a fetus has been identified as having a high nuchal translucency, mothers are usually offered chorionic villus sampling and a repeat scan about two weeks later to exclude chromosomal or major physical abnormalities.

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    Motherwillbe  (29-06-2012)

  3. #372
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    Quote Originally Posted by LillyPonds View Post
    Hi Ladies

    Kel the Downs scan is called the Nuchal Translucency NT for short.

    In the fetus fluid collects behind the neck, much like it does in dependent ankle oedema in later life. This occurs partly because of the fetus’s tendency to lie on its back and partly because of the laxity of the skin of the neck. As with ankle oedema this accumulation of fluid can represent the end point of several pathological processes, including heart failure. Fluid collecting behind the neck can be detected as nuchal translucency by ultrasound scanning, and it can be measured. The more fluid that has accumulated, the greater the risk of an abnormality being present.

    Chromosomal abnormalities—for example, Down’s syndrome—can cause fluid accumulation. Chromosome 21 contains the gene that codes for type VI collagen. In trisomy 21 one subunit of this collagen can be overexpressed, resulting in connective tissue that has a more elastic composition.
    Failure of fetal movements is also likely to cause nuchal thickening. Neuromuscular abnormalities can cause poor breathing and body movements, both of which may lead to fluid collecting as happens in peripheral oedema. One example is arthrogryposis, which causes contractures and flexion deformities and can be fatal. Other causes are intrathoracic and extrathoracic compressive syndromes. If the thoracic cage is abnormally narrow or an intrathoracic lesion is present (such as a diaphragmatic hernia) the vessels in the fetus’s head and neck become congested and oedema occurs. Likewise, if heart failure occurs (due to congenital cardiac abnormalities or cardiac dysfunction) more extravascular fluid will form.

    There is a brief opportunity between 10 and 14 weeks’ gestation (when the fetal lymphatic system is developing and the peripheral resistance of the placenta is high) to detect abnormal fluid collections. After 14 weeks the lymphatic system is likely to have developed sufficiently to drain away any excess fluid, and changes to the placental circulation will result in a drop in peripheral resistance. So after this time any abnormalities causing fluid accumulation may seem to correct themselves and can thus go undetected by measuring nuchal translucency.

    About 90% of fetuses with a nuchal translucency measurement of 3mm (“high”) at 12 weeks’ gestation are normal at birth, while 10% have major abnormalities. Only 10% of babies with a measurement of 6mm (“very high”) at this time will be found to be normal. In centres that perform nuchal translucency measurements, once a fetus has been identified as having a high nuchal translucency, mothers are usually offered chorionic villus sampling and a repeat scan about two weeks later to exclude chromosomal or major physical abnormalities.
    Wow thanks for such great detail...

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    LillyPonds  (29-06-2012)

  5. #373
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    No problem Dr Google is great for some thing lol.

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    Lillyponds - thanks for the info - that is amazingly detailed, but still quite concise.

    Nala - I can't believe the Dr wanted to do that. Grr. Hope you are feeling better soon.

  7. #375
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    Quote Originally Posted by Gampa View Post
    CMV is cytomegalovirus. It's part of the TORCH complex of viruses that are harmful in pregnancy. (TO= toxoplasmosis, R= rubella, C = cytomegalovirus, and H = herpes). You are screened on blood tests when you get pregnant. Most of us would have had these tsts as part of work up for IVf. If you haven't been go and get it done, your GP will know. Most people have had CMV as a teenager but there are a percentage of people that haven't- me included. Once you get it you can't get it again as you get immunity. However if you get when you are not pregnant it's no big deal, but if you are in the first trimester and you get one of those viruses it's devastating. cMV causes brain damage, blindness, deafness etc.....most people in first trimester end up loosing the baby, but if you don't then most likely your baby will be severely handicapped. We were almost at second trimester and we got a positive result on blood test and they sent us straight for an ultrasound- baby was dead.....as least we were spared the choice of having to terminate...but it felt like that anyway when labour was induced....... And then a D&C...

    My obstetrician has only seen 3 cases in his career- that's how rare it is to get it whilst you are pregnant. Just really bad luck but we had tried for that baby for 18 months so I couldn't understand why me and why when I was pregnant.....then I couldn't get pregnant again for the life of me and ended up on IvF....

    However on a happier note I'm 8 weeks today and sick as a dog with morning sickness!!cso I know my little precious bundle is ok even though I'm vomiting 5 times a day!!!

    weve all had very different journeys but we are all here now- yippeeeee......
    Im so sorry for your previous loss, i too have not heard of CMV, how devestating for you and your husband.

    No news from me, i have just read back through this thread, so much to take in lol.

    Im 10weeks today. Only another 13days until my NT scan.

    With my DD who is now nearly 3yrs old, through ICSI also, we had the NT done and BT done a week or so before hand. We were given a high chance of T21, and were offered further testing, but i declined. after research and discussion with my OB, at the time my maternal age was 25 so we decided against it.

    This time we are going to get the scan done and get the NF measured, but think we might decline the BT after the scan. If they will let me. As i feel that the NF and seeing if a nasal bone is present will do me just fine. If for example there is a soft marker or the NF is thick and in the high risk catagory, we will have the Bt done aswell, then take it from there.

    Hi everyone else.

    ivfmum

  8. #376
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    Lots of interesting info ladies. Good research.

    Well I'm 12 weeks today Have my nt scan on tues so can't wait for that extra confirmation.

    Has anyone watched that tv show one born every minute? It's on thurs night 9.30 sbs. It's great ..... Scary but good.

    Have a nice weekend everyone

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    LillyPonds  (02-07-2012)

  10. #377
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    I agree dr Google can be good but also can make us worry a lot more than necessary. But I know curiosity gets the better of us and how we just can't help it.

    Got my second bloods and hcg had gone from 201 on Monday to 1717 today ( great result to head into the weekend). Progesterone was 60.8 gone up a bit so happy with that too (considering I'm not on any pessaries or any thing).

    This is the first clinic( been with 4) that's procedure hasn't required pessaries after first blood test. Has anyone experienced this?

    Sent from my Nexus S using BubHub

  11. #378
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    Congrats that's so wonderful. 12 weeks is such a great achievement to celebrate

    Sent from my Nexus S using BubHub

  12. #379
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    Hi Ladies,

    I'm 13 weeks today and had my NT scan. Bub was a bit stubborn so took awhile to get the right pics, but all looks good. Just a bit of an FYI, I'm in Brisbane and the scan cost me $160. None of that is claimable on Medicare or PHI.

  13. #380
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    Quote Originally Posted by Motherwillbe View Post
    Lots of interesting info ladies. Good research.

    Well I'm 12 weeks today Have my nt scan on tues so can't wait for that extra confirmation.

    Has anyone watched that tv show one born every minute? It's on thurs night 9.30 sbs. It's great ..... Scary but good.

    Have a nice weekend everyone
    Congratulations for getting to your 12 weeks what a fantastic milestone you must be so excited for your scan!

    Don't even mention one born every minute!!! I'm obsessed!! I make sure in in bed at 8.30 every Monday as that is when it's on the lifestyle channel on fox and I just love it! I watch the uk version though, is the one on Thursday's Aussie? The American one was on last week and it was pretty average...


 

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