Hi. I'm 11 weeks and take 4mg of Zofran to ease the vomiting so I can work. It gives me incredible constipation. I get the urge to poo once every 3-4 days and by then it's too hard to come out. So painful and I had to go to the ER last week. The laxatives I was given don't work so I got a suppository which helped a fair bit but still hurt like hell. I eat well, lots of fibre, prunes and lots of fluid but I vomit so much too. Has anyone had this with Zofran? I think I need to use a suppository again as my bum is too sore from last week's attempt. Does anyone know if glycerol suppositories are ok to take 1-2 times a week? Sorry for all the details. I hope this ms ends soooooon.