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  1. #1
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    Default On the emotional rollercoaster - rolling with bad eggs...

    Hi all

    I guess I have been 'stalking' this site for a while now but I have actually never registered. I am now at a stage where I really feel like I need some advice and maybe even some support from others who might be going through the same thing.

    My husband and I are both 28 and lead pretty healthy lifestyles. We have had two IVF cycles and I have poor egg quality.

    I have had a laporoscopy, histerology and a histerosalpinogram (spelling?) I have signs of PCOS but everything else is 'perfect'. My husbands sperm is fine.

    Our first IVF cycle we had 13 eggs, four fertilised and none made it to blast - they all stopped growing at six cells and they had fragments. This was devastating.

    Our second IVF cylce we had 15 eggs and PICSI was performed on 13. Four fertlised and one was showing signs of getting to blast so it was transferred. The pregancy test was negative. Also devastating...

    After this result my husband and I came up with a plan - I guess this helps us deal with all of this. We are going to have one more IVF cycle and if the same thing happens we will go with an egg donor. If we are able to make one or more viable embryos then we will keep trying.

    Our specialist has told us that we may need to consider egg donation and there is not much that can be done for females with poor eggs. We have an appointment with her in the next month (or earlier) and I'm just trying to get some questions together. I want to ask about transferring more than one embryo at day three, DHEA, nutrition etc, what can be done overseas and participating in studies.

    I would be interested to hear about other people's journeys with bad egg quality and any advice would be much appreciated. I still can't believe this is happening... I just want to start a family...

    Thanks for listening.

  2. #2
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    Hi Rittzy,

    How frustrating for you (understatement!) when you are so young and getting good egg numbers.

    In terms of egg quality many people on Bubhub have had success with DHEA and it could really be worth a shot for you. other things mean to help egg quality are CQ10 supplement, royal jelly, good diet/ nutrition, no alcohol, coffee etc. chinese herbs. Recently i read wheat germ too.

    Even though your husbands sperm came back OK have they done a DNA fragmentation test? as sometimes the other measures are fine but this can be an issue that can cause problems with embryo's developing. sometimes eggs unfairly get the blame!!

    Good luck

  3. #3
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    Rittzy- So sorry to hear you're having a tough time with IVF.

    Your story is actually quite similar to mine, although I'm a little older then you (33). 1st cycle: 13 eggs, 2 embryos. 2nd cycle: 10 eggs, 1 embryo. 3rd cycle: 7 eggs, 1 embryo. Like you, the only problem they can find with me is mild PCO...

    Our FS suggested karotyping and it found DH has a chromosome issue (balanced translocation) but the FS said that doesn't properly explain our issues with low embryo numbers.

    I've now sought a 2nd opinion and the first thing my new FS has changed is the cycle type: we're trying a long down reg this time instead of an antagonist cycle, which is all I've done up til now. He also suggested DHEA might be an option, but he said he's not convinced that it makes a big difference for good responders but is more appropriate for helping poor responders with low egg numbers. One other thing he suggested was a longer 'coasting' period between trigger and pickup (an extra 2 hours) to allow for more eggs to mature better. Apparently this can be a problem with polycystic ovaries.

    Your ideas/questions to ask your FS sound like a good place to start. I can't really give you much more info on this topic as I'm still searching for my own answers but I guess getting karyotyping done (if you haven't already) might be something else for you to consider. I will let you know in a few weeks if the change in cycle type made any difference to our results!

    Good luck, Vesper

  4. #4
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    I know how you feel. We did our 5th cycle recently and all indicators point to our egg quality being our biggest hurdle.

    Another couple of things to thinks about:

    Melatonin - there is a study out of China? Which has indicated that 5mg of melatonin can help with egg quality.
    DHEA- could help and there are lots of ladies on BH who are on it - they do say you need to be taking it for our months before youncan really expect any difference.
    Something else I have seen but not yet spoken to fs is triggering slightly earlier ie we normally trigger when lead follicle is 20-22mm, but I am going to ask about trigger at 18-20mm.
    Accupuncture - not sure if it can help egg quality but might be worth checking. I have been doing it for about 20months and if nohing else it really helps the stress levels.
    Sugar - I have read that excess sugar intake can impact upon egg quality.

    Hopefully some of that helps.

  5. #5
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    EternalOptimist is offline Never say you have failed until you have reached your last attempt; never say you have reached your last attempt until you have succeeded.
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    Hi Rittzy,

    We also have crappy eggs and recently took a 3 month break to try and increase our chances. Along with heaps of other herbs and supps our naturopath put us on, she put DH on Vitamin E (400iui per day) and CoQ10 (150mg per day) which she said is VERY good to increase fert rates.


    She also told us that both of those things as well as a high dose of Vitamin C (1000mg per day) for women is really good for egg quality. There is a lot of research and most FS will tell you that that Egg quality cannot be changed and is purely a factor of age and the stimulation protocol your FS has you on and the timing of the trigger, however there is also a lot of research about decreasing oxidative stress in the follicular fluid that in turn will give you better quality eggs. The best way to decrease oxidative stress is through a high dose antioxidant. Google has hundreds of articles about antioxidants and oxidative stress if you wanna do a bit of research on them; i have spent weeks researching this before our next cycle.


    Like BronwynCJ mentioned above, the trigger can also have a huge impact on the quality of eggs. Our first cycle we triggered when the lead follies were 18—20mm due to imminent OHSS and we had a grade 1 blast transfer (BFP but MC at 8 weeks) and managed to get two great frosties that thawed perfectly and were transferred (sadly a chem. Pg and BFN), Our second stim cycle we triggered when the eggs were 20-22 as FS was waiting for some smaller follies to catch up as i was on a much smaller dose of FSH and had a crappy Day 5 transfer with no frosties (We barely even made it to day 5). There is a lot of info about protocol options and timing of triggers on the following website (I find this to be an awesome website for reference to take to your FS). http://www.ivfauthority.com/
    Last edited by EternalOptimist; 07-07-2011 at 13:21.

  6. #6
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    Hi Rittzy,

    I am a big advocate for DHEA. Our daughter was concieved through IVF after 5 months OF DHEA (we had been doing ivf for 2.5 years), I then started DHEA 6 months after she was born and we are now pregnant naturally after 5 months of DHEA! My hair started falling out, but is starting to grow again, a small price to pay for 2 miracles.

    The other thing that we used in the IVF cycle that our daughter came from was Luveris. It is meant to increase the quality of the eggs produced. It is expensive but you only need to take it for 5 days of your cycle and may be worth it considering you get a good number of eggs.

    There are certainly things you can do I believe before you need to go to egg donor. Maybe see another FS for a second opinion and mention some of the protocols people have mentioned here.

  7. #7
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    Hi everyone

    Thank you so much for your responses.

    I am going to look into everything that was suggested, especially the DHEA stuff and having additional tests done on DH's sperm.

    I think I might have four months off and try the DHEA and all the other supplements suggested. I now also have heaps of questions to ask my FS...I'm sure she will be impressed :-).

    Thanks again - all this information is really useful.

    Ritzzy


 

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