Felicita - so happy for you wonderful news!!!
Felicita - so happy for you wonderful news!!!
Sorry this is a huge post – trying to catch up on everyone
Felicita; That is absolutely fantastic news honey, you must be absolutely over the moon with your little super BLASTY. Now to sit back and let your little one snuggle into its new home for the next 8 months.
Kelbelle: Oh hon it’s a horrible predicament to be in. Like Felicita mentioned above, if you have Zero chances of falling naturally and the tubes could be affecting implantation due to the leakage then i would personally be having them removed. Did your FS think this was the reason why you have had no sign of implantation at all?
Paddlegirl: How did EPU go lovely, hopefully your at home resting after collecting all of those lovely eggies. Did your FS mention if there was anything you could take after EPU/before ET to help with the cold?
Sticky: Oh honey i am so sorry this is happening. It’s such a horrible journey to be on and it doesn’t sound silly at all that you miss your little embryo. Wow i love your idea of sexweek, i must admit we do that after a cycle as well. DH thinks all his Christmas’s come at once because we have abstained for the whole duration of our cycle.
Qartz: Great work on the message from your phone, mine ususaly end up being 2-3 lines from my Phone before it crashes and i loose my post. How is day 2 of the TWW going hon? Have you decided if you will do any HPT or just wait for the BT?
Lindylou: Have you caved and POAS yet? I had a funny feeling last night that you decided to do it a day early and it is positive. I’m dyeing to know what’s happening in your uterus right now.
Bella; How is the TWW going lovely? So sorry to hear your second little one didn’t defrost properly, but focus all your positive energy on the perfect hatching little one you have on board now and it making a nice new home for itself.
Angela: I usually have about 5 BT and 2 US for a natural FET, i find there is more monitoring for these than a stim cycle as they really have to make sure they can precisely pinpoint when you Ovulate. .
PinkB: Oh hon thanks for dropping in, how did your specialist appointment go?
Starfish: How is the ED cycle going hon? Any news on some dates?
Lola: How are you hon? Have you scheduled a WTF appointment with Dr B for when he is back?
Crofty: How are you feeling post EPU? So great abour your frosties, bring on November for your ET. You must be so happy with that many, was it because of the extra vitamins you were taking this time?.
TTHC: How are you going honey?
Traveller: I saw the story about gender selection as well and was furious. IVF is for people with medical reasons, this isn’t something we would choose if we were given a choice on how to conceive a baby. It makes IVF out to be a choice and really doesn’t reflect the pain and hardships we all go through to have our babies. I actually wrote an email to Sunrise about it having a huge winge. Like Felicita mentioned, it would be great if they could right a clause in the contracts that excess gender embryos could be donated. On a positive note, bring on November Cycle buddy.
AFM: Just hanging out waiting for AF, I’m guessing she is at least 2 weeks off yet, i am going for a BT next Friday to see where everything is up to. DH and i DTD last night and my ovaries are still so sore and swollen from the OHSS.
On my phone, had to drop in and cheer on Felicita!!!!!!! Woohoooo!!! So happy for you!!!!
Can I ask you a quick question? Why or whose 'fault' is it when an egg doesn't fertilize at all?
Hi to all the lovely Sydney ladies. Hope those who are PUPO are getting nice and pregnant
traveler - you're stretching my brain here. Where I run out of info I'll make up a good story, and if it doesn't contradict anything that we already know then it'll almost certainly be a true story.
I don't know exactly at which point you declare that fertilisation is successful, so we'll wander up to the first cell division to make 2 cells.
We'll go for ICSI, so that we don't have to worry about sperm acrosomes malfunctioning and can assume that one sperm and only one sperm gets into an egg. Ask again if you want IVF (without ICSI) prior to sperm entry discussed.
A mature egg is waiting patiently for a sperm to enter to signal the egg to complete it's cell division (which produces another polar body of DNA to throw away). Until this last step is complete you haven't yet finished creating the egg. (The immature eggs from EPU are at an earlier stage of cell division and aren't ready yet for this last step.) The spindle apparatus that they look for with PolScope (polarised light microscopy) shows if the mature egg is set up to do this last DNA division. If this last division isn't carried off correctly then you have failed to make your egg, and so fertilisation can't occur (or if it manages to squeeze through a loophole in the rules it won't be a viable embryo because it'll have trisomy of everything).
Then the DNA from the egg and the sperm need to get together. Both sets of DNA are packaged in a little bubble of oil and are called pronuclei. (A bubble is a thin layer of something that separates inside from outside. A drop is a "solid" sphere of something. The DNA is not in a drop of oil, it's inside a bubble of oil.) I gather that the pronuclei like to meet towards the middle of the egg, which means that both pronuclei need to be transported there which most likely will require proteins to drag them there or to conveyor-belt it into the right position. If the proteins are damaged they won't move along nicely.
The two pronuclei bubbles don't fuse together to make one bubble. They dissolve instead (i.e. "burst" in slow motion) leaving the two sets of DNA near each other. Both sets of DNA have been furiously making a complete copy of themselves so that they have one set each to hand down to the two cells created at the first cell division. Copying DNA isn't particularly accurate. Biology likes to allow a few mutations through to see if it comes up with an improvement. So quite a few things can go wrong during DNA copying.
Another spindle has to form, connect up to the chromosomes correctly and pull them apart so that you get one set of egg+sperm DNA on one side of the egg and another set of egg+sperm on the other side of the egg. So if this spindle doesn't function properly then at the two cell stage one is going to have received too many chromosomes and the other not enough, or it might not bother with creating two cells.
Then like in every normal cell division you have to package up those naked chromosomes into nuclei (by building an oil bubble around them) and chop the cell in half (by building an oil wall down the middle) and voila, if everything worked properly you have two cells each with a normal amount of DNA contributed by the egg and the sperm.
Last edited by felicita; 19-10-2011 at 13:11.
Felicita thats fantastic news - Woohoo!! Congrats on being PUPO!!
EO thanks for asking, yes I am at home resting now. FS did say on Sat that I could get antibiotics for the cold and stop taking them before ET. But when I went to the GP on Sat, he said it was viral and refused to prescribe antibiotics as he said it wouldnt help. GP suggested Codral Cold and Flu, so I just did that and tried to rest as much as possible. Still have a cold - runny nose and an occasional cough but they went ahead with EPU (and did it under GA) so I'm happy!
AFM - So I had 11 eggs taken out of me . That's a lot more than last time (5) so hoping for good fert. rates!
Nat- I hope my AF listens to you! When I first joined BH, I spent hours lurking in the ED forum and my heart really went out to those couples searching for their donor angel. I would LOVE to donate, but the way things are going, I'll be too old by the time my own IVF journey is over . Hope all is going well with your diet & wedding planning!
Bella- thanks for sending the PM about the acu guy, much appreciated. I've always wanted to get the pre/post ET treatment, but never found anyone within an hour of Liverpool. Problem solved now thanks to you! Hope your blasty has found a nice spot to snuggle into
Quartz- hope that sanity stays with you the whole TWW! Your thaw results are phenomenal, an embie that good is a sticky one for sure!
Felicita- WOO-HOO!! So incredibly happy for you being PUPO with a beautiful blastie . I knew it was a fighter! Yeah that Sharkey's questionnaire is a whopper, but you only need to do that if you want a personal herbal formula. The pre-ivf program they recommend is publicly accessible in their 'fertility tips' menu (so I'm not sharing something I shouldn't!). I've PM'd you the relevant bits. Apparantly it has yielded great results, EO speaks highly of that specific regime. I'll be doing it myself next stim . Best of luck for your TWW hun
Sticky- Oh you cracked me up with 'sexweek' . I totally understand missing your embie. I hope you can 'let go' and look ahead to the next embie soon.
Paddlegirl- Yay for 11 eggs! Hope you have a swift recovery from EPU and there's an awesome fert rate in tomorrow's news!
Kelbelle- sorry darl, I have no advice on your tube situation . Perhaps start a new thread and see what replies you get?
EO- haha you know me too well . Yes I caved yesterday, but contrary to your funny feeling it was BFN. Serves me right, it was much to early to use a 50mIU test .
Traveler- I hope you got the answer you were looking for!
Hi to Starf1sh, PinkB, Crofty, TTHC & Lola
AFM- So far, so good. AF not here and nor do I have her pre-arrival headache. As I said to EO, I did POAS yesterday and got BFN, but it means nothing because it wasn't an early detection test. Waste of a HPT, but the urge was too strong lol! Rather than test tonight, I think I'll just wait for tomorrow when AF is actually a day late. Or do I pop out to the chemist 2 mins away and get an FRER??
Yes pop out and get a frer lol
Lol Angela! Seriously tempted to... has your AF stayed away?
Lindylou - FRER! FRER! FRER!!!!!!! How many DPT are you?
Day 2 and the sanity ended!!! Had a mini meltdown at work today because I was just feeling very overwhelmed with everything I have to do - this normally wouldn't phase me but I think with added hormones and the stress of a new cycle it all got to me. Luckily I have the worlds best boss, who always knows how to make things better and she made me feel far less crazy!!!
Lindy - I agree FRER!!!!!!!
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