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  1. #1
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    Default Thyroid Antibodies and IVF

    Hi Dr Sterling,

    My husband and I have been trying to conceive for 6 years now. I am 32 and he is 37. We have known about his low sperm count since 2007 and first tried natural therapies & healthier lifestyle to improve the numbers. We did get them to increase from 0.4million/mL up to 5 million/mL and started ICSI in Jul this year. Fresh embryo transfer in July didn't work, nor did frozen transfer in Aug. We still have 4 frozen blastocysts. We were told that all 6 of our blastocysts were top notch and had a good chance of implanting.

    Up to now, the focus has always been on my DH as the reason for our infertility. My tests always came back as being perfect, I don't drink or smoke and my BMI is 22. However, after our second failed cycle I requested more testing for myself, simply because I don't want to use up all our embryos, only to find out at the end that there is something wrong with me too.

    Through these extra tests, we have discovered that I have elevated thyroid antibodies yet normal TSH, T3 & T4. The antithyroglobulin was normal, but thyroid peroxidase was over 1000 (normal limits 0-35).

    My FS said that because TSH, T3 and T4 are normal, that I don't need any treatment and that the high antibodies have no impact on my ability to fall pregnant.

    We are about to undergo our 3rd cycle, this time transferring 2 of our remaining 4 frosties. I am concerned that I should be taking prednisolone to counter-act the antibodies and that I will continue to have failed cycles if left untreated.

    Do you agree with my FS that the antibodies are irrelevant? Should I seek advice from an endocrinologist?

    Thank you in advance for your help!

  2. #2
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    I would discuss your concerns with your specialist and ask if a review would be helpful from an endocrinologist. This way all parties will be happy before further transfers. Good Luck GS

  3. #3
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    I was going to revisit the topic with my FS, but had hoped for a second opinion from a credible source! When I produced the list of advanced infertility testing that I wanted, I got the speech about how google is the specialists worst nightmare...

    I have found a number of journal articles, plus info from my naturopath that links high TPO with infertility, miscarriage & premature labour. So I'll just arm myself with those and see how I go.

    Thanks.


 

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